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Moolman, M.C. (author), Huang, Z. (author), Krishnan, S.T. (author), Kerssemakers, J.W.J. (author), Dekker, N.H. (author)Background: Controlled restriction of cellular movement using microfluidics allows one to study individual cells to gain insight into aspects of their physiology and behaviour. For example, the use of micron-sized growth channels that confine individual Escherichia coli has yielded novel insights into cell growth and death. To extend this...journal article 2013
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Van den Heuvel, M.G.L. (author), Bondesan, R. (author), Lagomarsino, M.C. (author), Dekker, C. (author)We use fluorescence microscopy to measure the orientation and shape of microtubules—which serve as a model system for semiflexible rods—that are electrophoretically driven. Surprisingly, a bimodal orientation distribution is observed, with microtubules in either parallel or perpendicular orientations to the electric field. The occupancy of these...journal article 2008
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Krishnan, S.T. (author), Moolman, M.C. (author), Van Laar, T. (author), Meyer, A.S. (author), Dekker, N.H. (author)Background Chromosome engineering encompasses a collection of homologous recombination-based techniques that are employed to modify the genome of a model organism in a controlled fashion. Such techniques are widely used in both fundamental and industrial research to introduce multiple insertions in the same Escherichia coli strain. To date, ?...journal article 2015
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- Tans, S.J. (author), Devoret, M.H. (author), Dai, H. (author), Thess, A. (author), Smalley, R.E. (author), Georliga, L.J. (author), Dekker, C. (author) journal article 1997
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- Blok, Jan J. (author), Dekker, J.N. (author) journal article 1980
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- Dekker, J.P. (author), Van der Put, P.J. (author), Veringa, H.J. (author), Schoonman, J. (author) journal article 1994
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- Moreno-Herrero, F. (author), Seidel, R. (author), Johnson, S.M. (author), Fire, A. (author), Dekker, N.H. (author) journal article 2006
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Dekker, R. (author)“A what on a chip?” is what most people ask with disbelief when they hear for the first time of the new and very exciting research area “Organ on a Chip.” The topic has nothing to do with Science Fiction, but everything with a very surprising encounter between two completely different research fields: Microfabrication and Stem-Cell Biology! The...journal article 2013
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- Moene, R. (author), Dekker, J.P. (author), Makkee, M. (author), Schoonman, J. (author), Moulijn, J.A. (author) journal article 1994
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- Crut, A. (author), Koster, D.A. (author), Huang, Z. (author), Hage, S. (author), Dekker, N.H. (author) journal article 2008
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- Stein, D. (author), Kruithof, M. (author), Dekker, C. (author) journal article 2004
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Vilfan, I.D. (author), Candelli, A. (author), Hage, S. (author), Aalto, A.P. (author), Poranen, M.M. (author), Bamford, D.H. (author), Dekker, N.H. (author)RNA-dependent RNA polymerases (RdRP) form an important class of enzymes that is responsible for genome replication and transcription in RNA viruses and involved in the regulation of RNA interference in plants and fungi. The RdRP kinetics have been extensively studied, but pausing, an important regulatory mechanism for RNA polymerases that has...journal article 2008
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Delhez, A.N. (author), De Leeuwe, J. (author), Dekker, R. (author)Purpose – To discuss the recent strategic developments of Library at TU Delft. Design/methodology/approach – Developments at TU Delft are contrasted with the five key requirements for document delivery identified in an earlier article in 2001. Findings – That the strategy in most libraries is to evolve rapidly to a digital library as far as...journal article 2005
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- Dekker, C. (author), Arts, A.F.M. (author) journal article 1988
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- Tans, S.J. (author), Miedema, R. (author), Geerligs, L.J. (author), Dekker, C. (author), Wu, J. (author), Wegner, G. (author) journal article 1997
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Klein, S. (author), Vast, E. (author), Van Soest, J. (author), Dekker, A. (author), Koek, M. (author), Niessen, W.J. (author)1st Clinical Research Informatics (CRI) Solutions Day Duesseldorf, Germany, 26-27 May 2014journal article 2015
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- LeRoy, B.J. (author), Kong, J. (author), Pahilwani, V.K. (author), Dekker, C. (author), Lemay, S.G. (author) journal article 2005
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Van den Hout, M. (author), Hall, A.R. (author), Wu, M.Y. (author), Zandbergen, H.W. (author), Dekker, C. (author), Dekker, N.H. (author)Solid-state nanopores are considered a promising tool for the study of biological polymers such as DNA and RNA, due largely to their flexibility in size, potential in device integration and robustness. Here, we show that the precise shape of small nanopores (?5 nm diameter in 20 nm SiN membranes) can be controlled by using transmission electron...journal article 2010
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Van der Heijden, T. (author), Seidel, R. (author), Modesti, M. (author), Kanaar, R. (author), Wyman, C. (author), Dekker, C. (author)The human DNA repair protein RAD51 is the crucial component of helical nucleoprotein filaments that drive homologous recombination. The molecular mechanistic details of how this structure facilitates the requisite DNA strand rearrangements are not known but must involve dynamic interactions between RAD51 and DNA. Here, we report the real-time...journal article 2007
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Storm, A.J. (author), Chen, J.H. (author), Ling, X.S. (author), Zandbergen, H.W. (author), Dekker, C. (author)The imaging beam of a transmission electron microscope can be used to fine tune critical dimensions in silicon oxide nanostructures. This technique is particularly useful for the fabrication of nanopores with single-nanometer precision, down to 2 nm. We report a detailed study on the effect of electron-beam irradiation on apertures with various...journal article 2005