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Laan, Rianne (author), Nout, Remi A. (author), Dankelman, J. (author), van de Berg, N.J. (author)Background:<br/> Brachytherapy involves placement of radioactive sources inside or near the tumour. For gynaecological cancer, recent developments, including 3D imaging and image-guided adaptive brachytherapy, have improved treatment quality and outcomes. However, for large or complex tumours, target coverage and local control with commercially...journal article 2019
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Hakkaart, X.D.V. (author), Pronk, J.T. (author), van Maris, A.J.A. (author)Understanding microbial growth and metabolism is a key learning objective of microbiology and biotechnology courses, essential for understanding microbial ecology, microbial biotechnology and medical microbiology. Chemostat cultivation, a key research tool in microbial physiology that enables quantitative analysis of growth and metabolism under...journal article 2017
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Bekker, A.C.M. (author), Verlinden, J.C. (author)Wire and Arc Additive Manufacturing (WAAM) is a metal 3D printing technique based on robotic welding. This technique yields potential in decreasing material consumption due to its high material efficiency and freedom of shape. Empirical measurements of WAAM, using a deposition rate of 1 kg/h, were performed on site of MX3D. The measured power...journal article 2018
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Li, Y. (author), Zhou, J. (author), Pavanram, P. (author), Leeflang, M.A. (author), Fockaert, L.I. (author), Pouran, B. (author), Tümer, N. (author), Schröder, K. U. (author), Mol, J.M.C. (author), Weinans, Harrie (author), Jahr, H. (author), Zadpoor, A.A. (author)An ideal bone substituting material should be bone-mimicking in terms of mechanical properties, present a precisely controlled and fully interconnected porous structure, and degrade in the human body to allow for full regeneration of large bony defects. However, simultaneously satisfying all these three requirements has so far been highly...journal article 2017
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Hille, Helge C. (author), Kumar, Siddhant (author), De Lorenzis, Laura (author)We propose Floating Isogeometric Analysis (FLIGA), which extends IGA to extreme deformation analysis. The method is based on a novel tensor-product construction of B-Splines for the update of the basis functions in one direction of the parametric space. With basis functions “floating” deformation-dependently in this direction, mesh distortion...journal article 2022
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Pfarr, Daniel (author), Louter, P.C. (author)The use of thin glass promises to enable a variety of construction industry pursuits. In addition to the ecological benefits of more efficient use of resources, architects can anticipate new design freedoms with thin glass. Based on the sandwich theory, the flexible thin glass can be combined with a 3D-printed open-cell polymer core to form a...journal article 2023
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Setaki, F. (author), Tian, F. (author), Turrin, M. (author), Tenpierik, M.J. (author), Nijs, L. (author), van Timmeren, A. (author)This paper discusses a novel, compact sound absorption solution with high performance at various frequencies, including low frequencies, achieved through the effective use of Computational Design and Additive Manufacturing (AM). Sound absorption is widely applied for reducing noise and improving room acoustics; however, it is often constrained...journal article 2023
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Sobota, V.C.M. (author), van de Kaa, G. (author), Luomaranta, Toni (author), Martinsuo, Miia (author), Ortt, J.R. (author)Purpose: This paper addresses the most important factors for the selection of additive manufacturing (AM) technology as a method of production of metal parts. AM creates objects by adding material layer by layer based on 3D models. At present, interest in AM is high as it is hoped that AM contributes to the competitiveness of Western...journal article 2020
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Dong, J. (author), Tümer, N. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zadpoor, A.A. (author), Zhou, J. (author)Porous biodegradable Mg and its alloys are considered to have a great potential to serve as ideal bone substitutes. The recent progress in additive manufacturing (AM) has prompted its application to fabricate Mg scaffolds with geometrically ordered porous structures. Extrusion-based AM, followed by debinding and sintering, has been recently...journal article 2022
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van de Ven, E.A. (author), Maas, Robert (author), Ayas, C. (author), Langelaar, Matthijs (author), van Keulen, A. (author)Although additive manufacturing (AM) allows for a large design freedom, there are some manufacturing limitations that have to be taken into consideration. One of the most restricting design rules is the minimum allowable overhang angle. To make topology optimization suitable for AM, several algorithms have been published to enforce a minimum...journal article 2021
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Oldhoff, M. G.E. (author), Mirzaali, Mohammad J. (author), Tümer, N. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additive manufacturing (AM) offers great design freedom that enables objects with desired unique and complex geometry and topology to be readily and cost-effectively fabricated. The overall benefits of AM are well known, such as increased material and resource efficiency, enhanced design and production flexibility, the ability to create...journal article 2021
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Kerstens, Fabio (author), Cervone, A. (author), Gradl, P.R. (author)High performance liquid rocket engines require cooling to maintain structural integrity of the combustion chamber which is exposed to high thermal and environmental loads. For many systems, this is achieved by means of regenerative cooling, where a coolant flows through passages around the chamber wall whilst extracting heat from the wall. A...journal article 2021
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Misiun, Grzegorz (author), van de Ven, E.A. (author), Langelaar, Matthijs (author), Geijselaers, Hubert (author), van Keulen, A. (author), van den Boogaard, Ton (author), Ayas, C. (author)An important cause of failure in powder bed additive manufacturing is the distortion of the part due to thermal shrinkage during printing and the relaxation of residual stresses after its release from the base plate. In this paper, Additive Manufacturing simulations are coupled with Topology Optimization in order to generate designs that are...journal article 2021
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Mishra, V. (author), Ayas, C. (author), Langelaar, Matthijs (author), van Keulen, A. (author)A remarkable elastic anisotropy in plates of austenitic stainless steel produced by the Wire and Arc Additive Manufacturing process is recently reported. The Young's modulus depends on the angle of orientation with respect to the material deposition direction. Here, for the first time, this anisotropy is exploited to maximize structural...journal article 2022
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Maicas Esteve, H. (author), Taji, Iman (author), Wilms, M.E. (author), Gonzalez Garcia, Y. (author), Johnsen, Roy (author)The use of metal additive manufacturing (AM) has strongly increased in the industry during the last years. More specifically, selective laser melting (SLM) is one of the most used techniques due to its numerous advantages compared to conventional processing methods. The purpose of this study is to investigate the effects of process parameters...journal article 2022
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Salvati, Enrico (author), Tognan, Alessandro (author), Laurenti, L. (author), Pelegatti, Marco (author), De Bona, Francesco (author)Defects in additively manufactured materials are one of the leading sources of uncertainty in mechanical fatigue. Fracture mechanics concepts are useful to evaluate their influence, nevertheless, these approaches cannot account for the real morphology of defects. Preliminary attempts to exploit a more comprehensive description of defects can...journal article 2022
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Ranjan, R. (author), Ayas, C. (author), Langelaar, Matthijs (author), van Keulen, A. (author)A novel constraint to prevent local overheating is presented for use in topology optimization (TO). The very basis for the constraint is the Additive Manufacturing (AM) process physics. AM enables fabrication of highly complex topologically optimized designs. However, local overheating is a major concern especially in metal AM processes...journal article 2022
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Nouri Goushki, M. (author), Eijkel, B.I.M. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Modulation of the immune response following the implantation of biomaterials can have beneficial effects on bone regeneration. This involves complex interactions between the inflammatory and osteogenic cells. Therefore, the study of cell-cell interactions using direct co-culture models integrated with biomaterials is of great interest. This...journal article 2022
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Yan, Z. (author), Zhu, Jia-Ning (author), Borisov, Evgenii (author), Riemslag, A.C. (author), Scott, S.P. (author), Hermans, M.J.M. (author), Jovanova, J. (author), Popovich, V. (author)In energy absorption applications, architectured metallic materials generally suffer from unrecoverable deformation as a result of local yield damage or inelastic buckling. Nitinol (NiTi) offers recoverable deformation and energy dissipation due to its unique superelasticity, which can change the way we design and additively manufacture...journal article 2023
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Rans, C.D. (author), Michielssen, J. (author), Walker, M.S. (author), Wang, W. (author), Hoen-Velterop, Ludmila ’t (author)A challenge in developing an in-depth understanding of the crack growth resistance of Additively Manufactured materials is the fact that their mechanical properties have been shown to be both process and part-geometry dependent. Up to now, no studies have investigated the influence of off-axis (beyond the three orthogonal build orientations)...journal article 2018