Extracellular and intracellular effects of bioactive glass nanoparticles on osteogenic differentiation of bone marrow mesenchymal stem cells and bone regeneration in zebrafish osteoporosis model

Bioactive glass nanoparticles (BGNs) are well-recognized multifunctional biomaterials for bone tissue regeneration due to their capability to stimulate various cellular processes through released biologically active ions. Understanding the correlation between BGN composition and cellular responses is key to developing clinically usable BGN...

Synergistic effects of cerium-containing bioactive glasses and apoptotic extracellular vesicles alleviate bisphosphonate-related osteonecrosis of jaw

Bisphosphonates (BPs) are commonly used to treat skeletal diseases. However, long-term use of BPs can lead to BP-related jaw bone necrosis (BRONJ), particularly in patients undergoing tooth extraction surgery. The treatment of BRONJ remains challenging due to the local inflammatory microenvironment. To address this issue, we developed...