document

Question-based development of high-risk medical devices: A proposal for a structured design and review process

White, N.A. (author), Oude Vrielink, Timo J.C. (author), van der Bogt, Koen E.A. (author), Cohen, Adam F. (author), Rotmans, Joris I. (author), Horeman, T. (author)

Introduction: The recent introduction of the European Medical Device Regulation poses stricter legislation for manufacturers developing medical devices in the EU. Many devices have been placed into a higher risk category, thus requiring more data before market approval, and a much larger focus has been placed on safety. For implantable and...

journal article 2023

document

The role of wind-wave related processes in redistributing river-derived terrigenous sediments in Lake Turkana: A modelling study

Zăinescu, Florin (author), van der Vegt, Helena (author), Storms, J.E.A. (author), Nutz, Alexis (author), Bozetti, Guilherme (author), May, Jan-Hendrik (author), Cohen, Sagy (author), Bouchette, Frederic (author), May, Simon Matthias (author), Schuster, Mathieu (author)

A complete annual cycle of the dynamics of fine-grained sediment supplied by the Omo and smaller rivers is simulated for Lake Turkana, one of the world’s large lakes, with the hydrodynamic, wave and sediment transport model Delft3D. The model is forced with river liquid and solid discharge and wind data in order to simulate cohesive sediment...

journal article 2023

document

An adaptive robust optimization model for parallel machine scheduling

Cohen, Izack (author), Postek, K.S. (author), Shtern, Shimrit (author)

Real-life parallel machine scheduling problems can be characterized by: (i) limited information about the exact task duration at the scheduling time, and (ii) an opportunity to reschedule the remaining tasks each time a task processing is completed and a machine becomes idle. Robust optimization is the natural methodology to cope with the first...

journal article 2022

document

The climate impact of hydrogen-powered hypersonic transport

Pletzer, Johannes (author), Hauglustaine, Didier (author), Cohen, Yann (author), Jöckel, Patrick (author), Grewe, V. (author)

Hypersonic aircraft flying at Mach 5 to 8 are a means for traveling very long distances in extremely short times and are even significantly faster than supersonic transport (Mach 1.5 to 2.5). Fueled with liquid hydrogen (LH2), their emissions consist of water vapor (H2O), nitrogen oxides (NOx), and unburned hydrogen. If LH2 is produced in a...

journal article 2022

document

Autonomous control for miniaturized mobile robots in unknown pipe networks

Nguyen, T.L. (author), Blight, A. (author), Pickering, A. (author), Jackson-Mills, G. (author), Barber, A. R. (author), Boyle, J.H. (author), Richardson, R. (author), Dogar, M. (author), Cohen, N. (author)

Despite recent advances in robotic technology, sewer pipe inspection is still limited to conventional approaches that use cable-tethered robots. Such commercially available tethered robots lack autonomy, and their operation must be manually controlled via their tethered cables. Consequently, they can only travel to a certain distance in pipe,...

journal article 2022

document

Photoactivated voltage imaging in tissue with an archaerhodopsin-derived reporter

Chien, M.P. (author), Brinks, D. (author), Testa-Silva, Guilherme (author), Tian, He (author), Brooks, F. Phil (author), Adam, Yoav (author), Bloxham, William (author), Gmeiner, Benjamin (author), Kheifets, Simon (author), Cohen, A.E. (author)

Photoactivated genetically encoded voltage indicators (GEVIs) have the potential to enable optically sectioned voltage imaging at the intersection of a photoactivation beam and an imaging beam. We developed a pooled high-throughput screen to identify archaerhodopsin mutants with enhanced photoactivation. After screening ~10⁵ cells,...

journal article 2021

document

A multifunctional matching algorithm for sample design in agricultural plots

Ohana-Levi, N. (author), Derumigny, Alexis (author), Peeters, A. (author), Ben-Gal, A. (author), Bahat, I. (author), Katz, L. (author), Netzer, Y. (author), Naor, A. (author), Cohen, Y. (author)

Collection of accurate and representative data from agricultural fields is required for efficient crop management. Since growers have limited available resources, there is a need for advanced methods to select representative points within a field in order to best satisfy sampling or sensing objectives. The main purpose of this work was to...

journal article 2021

document

Efficacy of augmented visual environments for reducing sickness in autonomous vehicles

de Winkel, K.N. (author), Pretto, Paolo (author), Nooij, Suzanne A.E. (author), Cohen, Iris (author), Bülthoff, Heinrich H. (author)

The risk of motion sickness is considerably higher in autonomous vehicles than it is in human-operated vehicles. Their introduction will therefore require systems that mitigate motion sickness. We investigated whether this can be achieved by augmenting the vehicle interior with additional visualizations. Participants were immersed in motion...

journal article 2021

document

Panorama New Netherlands

Timmermans, Jos (author), Storms, J.E.A. (author), Pleijster, Eric-Jan (author), van der Meulen, G.J.M. (author), van Alphen, Jos (author), Haasnoot, Marjolein (author), Diermanse, FLM (author), Cohen, Kim M. (author), Minderhoud, Philip (author), Leuven, Jasper R.F.W. (author), Gerritsen, Kari-Anne (author), van Buuren, Michaël (author), van Boxel, Elma (author), Koreman, Kristian (author), Sanaan Bensi, N. (author)

How can the Netherlands adapt to sea level rise on the long term: maintain, advance or retreat? This article compares the results of seven plans and designs from a diverse group of scholars and professionals that offer very different answers to this question. This diversity broadens the options, which is vital in this stage. Both problem solving...

journal article 2020

document

Optomechanical Microwave Amplification without Mechanical Amplification

Cohen, M.A. (author), Bothner, D. (author), Blanter, Y.M. (author), Steele, G.A. (author)

High-gain and low-noise signal amplification is a valuable tool in various cryogenic microwave experiments. A microwave optomechanical device, in which a vibrating capacitor modulates the frequency of a microwave cavity, is one technique that is able to amplify microwave signals with high gain and large dynamical range. Such optomechanical...

journal article 2020

document

Middle Paleolithic complex technology and a Neandertal tar-backed tool from the Dutch North Sea

Niekus, Marcel J. L. Th. (author), Kozowyk, Paul R. B. (author), Langejans, G.H.J. (author), Ngan-Tillard, D.J.M. (author), van Keulen, Henk (author), van der Plicht, Johannes (author), Cohen, Kim M. (author), van Os, Bertil (author), Smit, Bjørn I. (author)

We report the discovery of a 50,000-y-old birch tar-hafted flint tool found off the present-day coastline of The Netherlands. The production of adhesives and multicomponent tools is considered complex technology and has a prominent place in discussions about the evolution of human behavior. This find provides evidence on the technological...

journal article 2019

document

Extensive global movement of multidrug-resistant M. tuberculosis strains revealed by whole-genome analysis

Cohen, Keira A. (author), Manson, Abigail L. (author), Abeel, T.E.P.M.F. (author), Desjardins, Christopher A. (author), Chapman, Sinead B. (author), Hoffner, Sven (author), Birren, Bruce W. (author), Earl, Ashlee M. (author)

Background: While the international spread of multidrug-resistant (MDR) Mycobacterium tuberculosis strains is an acknowledged public health threat, a broad and more comprehensive examination of the global spread of MDR-tuberculosis (TB) using whole-genome sequencing has not yet been performed. Methods: In a global dataset of 5310 M....

journal article 2019

document

Sea-level change in the Dutch Wadden Sea

Vermeersen, L.L.A. (author), Baart, F. (author), Cohen, Kim M. (author), Frederikse, T. (author), Kiden, Patrick (author), Kleinherenbrink, M. (author), Riva, R.E.M. (author), Slobbe, D.C. (author), van der Wegen, M. (author)

Rising sea levels due to climate change can have severe consequences for coastal populations and ecosystems all around the world. Understanding and projecting sea-level rise is especially important for low-lying countries such as the Netherlands. It is of specific interest for vulnerable ecological and morphodynamic regions, such as the...

journal article 2018

document

A split-cavity design for the incorporation of a DC bias in a 3D microwave cavity

Cohen, M.A. (author), Yuan, M. (author), de Jong, B.W.A. (author), Beukers, Ewout (author), Bosman, S.J. (author), Steele, G.A. (author)

We report on a technique for applying a DC bias in a 3D microwave cavity. We achieve this by isolating the two halves of the cavity with a dielectric and directly using them as DC electrodes. As a proof of concept, we embed a variable capacitance diode in the cavity and tune the resonant frequency with a DC voltage, demonstrating the...

journal article 2017

document

Hospital versus individual surgeon’s performance in laparoscopic hysterectomy

Driessen, Sara R C (author), Wallwiener, Markus (author), Taran, Florin Andrei (author), Cohen, Sarah L. (author), Kraemer, Bernhard (author), Wallwiener, Christian W. (author), Van Zwet, Erik W. (author), Brucker, Sara Y. (author), Jansen, F.W. (author)

Purpose: To compare hospital versus individual surgeon’s perioperative outcomes for laparoscopic hysterectomy (LH), and to assess the relationship between surgeon experience and perioperative outcomes. Methods: A retrospective analysis of all prospective collected LHs performed from 2003 to 2010 at one medical center was performed....

journal article 2017

document

Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance

Manson, Abigail L. (author), Cohen, Keira A (author), Abeel, T.E.P.M.F. (author), Desjardins, Christopher A. (author), Armstrong, Derek T. (author), Barry III, Clifton E. (author), Brand, Jeannette (author), Chapman, Sinéad B. (author), Cho, Sang-Nae (author), Gabrielian, Andrei (author), Salazar, A.N. (author)

Multidrug-resistant tuberculosis (MDR-TB), caused by drug-resistant strains of Mycobacterium tuberculosis, is an increasingly serious problem worldwide. Here we examined a data set of whole-genome sequences from 5,310 M. tuberculosis isolates from five continents. Despite the great diversity of these isolates with respect to geographical...

journal article 2017

document

Effects of different real-time feedback types on human performance in high-demanding work conditions

Cohen, I. (author), Brinkman, W.P. (author), Neerincx, M.A. (author)

Experiencing stress during training is a way to prepare professionals for real-life crises. With the help of feedback tools, professionals can train to recognize and overcome negative effects of stress on task performances. This paper reports two studies that empirically examined the effect of such a feedback system. The system, based on the...

journal article 2016

document

Silicon nitride membrane resonators at millikelvin temperatures with quality factors exceeding 10^8

Yuan, M. (author), Cohen, M.A. (author), Steele, G.A. (author)

We study the mechanical dissipation of the fundamental mode of millimeter-sized, high quality-factor (Q) metalized silicon nitride membranes at temperatures down to 14?mK using a three-dimensional optomechanical cavity. Below 200?mK, high-Q modes of the membranes show a diverging increase of Q with decreasing temperature, reaching Q=1.27×108Q=1...

journal article 2015

document

Modelling environmental and cognitive factors to predict performance in a stressful training scenario on a naval ship simulator

Cohen, I. (author), Brinkman, W.P. (author), Neerincx, M.A. (author)

Professionals working in risky or emergency situations have to make very accurate decisions, while the quality of the decisions might be affected by the stress that these situations bring about. Integrating task feedback and biofeedback into computer-based training environments could improve trainees’ stress-coping behaviour. This paper presents...

journal article 2015

document

Observation of slant column NO2 using the super-zoom mode of AURA-OMI

Valin, L.C. (author), Russell, A.R. (author), Bucsela, E.J. (author), Veefkind, J.P. (author), Cohen, R.C. (author)

We retrieve slant column NO2 from the superzoom mode of the Ozone Monitoring Instrument (OMI) to explore its utility for understanding NOx emissions and variability. Slant column NO2 is operationally retrieved from OMI (Boersma et al., 2007; Bucsela et al., 2006) with a nadir footprint of 13×24 km2, the result of averaging eight detector...

journal article 2011