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Dupuits, E.J.C. (author), Schweckendiek, T. (author), Kok, M. (author)Coastal flood defense systems can consist of multiple lines of defense. In case of a system with a front and a rear defense (e.g. a storm surge barrier and levees), the front defense can improve the reliability of the rear defense by reducing the load on this rear defense. This paper develops a framework in order to assess whether including...journal article 2017
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Baltussen, Elisabeth J.M. (author), Snaebjornsson, Petur (author), De Koning, Susan G.Brouwer (author), Sterenborg, Henricus J.C.M. (author), Aalbers, Arend G.J. (author), Kok, Niels (author), Beets, Geerard L. (author), Hendriks, B.H.W. (author), Kuhlmann, Koert F.D. (author), Ruers, Theo J.M. (author)Colorectal surgery is the standard treatment for patients with colorectal cancer. To overcome two of the main challenges, the circumferential resection margin and postoperative complications, real-time tissue assessment could be of great benefit during surgery. In this ex vivo study, diffuse reflectance spectroscopy (DRS) was used to...journal article 2017
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van Gelder, Celia W.G. (author), Hooft, Rob W.W. (author), van Rijswijk, Merlijn N. (author), van den Berg, Linda (author), Kok, Ruben G. (author), Reinders, M.J.T. (author), Mons, Barend (author), Heringa, Jaap (author)This review provides a historical overview of the inception and development of bioinformatics research in the Netherlands. Rooted in theoretical biology by foundational figures such as Paulien Hogeweg (at Utrecht University since the 1970s), the developments leading to organizational structures supporting a relatively large Dutch bioinformatics...journal article 2017
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Stoter, J.E. (author), Ploeger, H.D. (author), Roes, Ruben (author), van der Riet, Els (author), Biljecki, F. (author), Ledoux, H. (author), Kok, Dirco (author), Kim, S. (author)This article reports on the first 3D cadastral registration in The Netherlands, accomplished in March 2016. The solution was sought within the current cadastral, organisational, and technical frameworks to obtain a deeper knowledge on the optimal way of implementing 3D registration, while avoiding discussions between experts from different...journal article 2017
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Vleugel, M. (author), Kok, M.W.A. (author), Dogterom, A.M. (author)Microtubules switch between growing and shrinking states, a feature known as dynamic instability. The biochemical parameters underlying dynamic instability are modulated by a wide variety of microtubule-associated proteins that enable the strict control of microtubule dynamics in cells. The forces generated by controlled growth and shrinkage...journal article 2016
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Kok, Annette M. (author), Speelman, Lambert (author), Virmani, Renu (author), van der Steen, A.F.W. (author), Gijsen, F.J.H. (author), Wentzel, Jolanda J. (author)Background: Stress calculations in atherosclerotic coronary vulnerable plaques can aid in predicting coronary cap rupture. In vivo plaque geometry and composition of coronary arteries can merely be obtained via intravascular imaging. Only optical driven imaging techniques have sufficient resolution to visualize the fibrous cap, but due to...journal article 2016
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Farle, A.M. (author), Boatemaa, L. (author), Shen, L. (author), Gövert, S. (author), Kok, J.E. (author), Bosch, M (author), Yoshioka, S. (author), van der Zwaag, S. (author), Sloof, W.G. (author)Closure of surface cracks by self-healing of conventional and MAX phase ceramics under realistic turbulent combustion chamber conditions is presented. Three ceramics namely; Al<sub>2</sub>O<sub>3</sub>, Ti<sub>2</sub>AlC and Cr<sub>2</sub>AlC are investigated. Healing was achieved in Al<sub>2</sub>O<sub>3</sub> by even dispersion of TiC...journal article 2016
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- Nillesen, A.L. (author), Kok, M. (author) journal article 2015
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Natenstedt, J. (author), Kok, A.C. (author), Dankelman, J. (author), Tuijthof, G.J.M. (author)Articular cartilage has limited regeneration capacities. One of the factors that appear to affect the in vitro cultivation of articular cartilage is mechanical stimulation. So far, no combination of parameters has been identified that offers the best results. The goal is to review the literature in search of the best available set of...journal article 2015
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Tsimopoulou, V. (author), Kok, M. (author), Vrijling, J.K. (author)After the flood disaster of 1953, the Netherlands adopted a rational approach to flood risk management with the use of protection standards determined by means of cost-benefit analysis. Due to scientific and political developments that have recently taken place, an update of the Dutch protection standards is being undertaken. One of the major...journal article 2015
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- Spekkers, M.H. (author), Kok, M. (author), Clemens, F.H.L.R. (author), Ten Veldhuis, J.A.E. (author) journal article 2014
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Cernohorsky, P. (author), Kok, A.C. (author), De Bruin, D.M. (author), Brandt, M.J. (author), Faber, D.J. (author), Tuijthof, G.J.M. (author), Kerkhoffs, G.M. (author), Strackee, S.D. (author), Van Leeuwen, T.G. (author)Background and purpose — Optical coherence tomography (OCT) is a light-based imaging technique suitable for depiction of thin tissue layers such as articular cartilage. Quantification of results and direct comparison with a reference standard is needed to confirm the role of OCT in cartilage evaluation. Materials and methods — Goat talus...journal article 2014
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Dzyubachyk, O. (author), Khmelinskii, A. (author), Plenge, E. (author), Kok, P. (author), Snoeks, T.J. (author), Poot, D.H. (author), Löwik, C.W. (author), Botha, C.P. (author), Niessen, W.J. (author), Van der Weerd, L. (author), Meijering, E. (author), Lelieveldt, B.P.F. (author)In small animal imaging studies, when the locations of the micro-structures of interest are unknown a priori, there is a simultaneous need for full-body coverage and high resolution. In MRI, additional requirements to image contrast and acquisition time will often make it impossible to acquire such images directly. Recently, a resolution...journal article 2014
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Van den Akker, E.B. (author), Passtoors, W.M. (author), Jansen, R. (author), Van Zwet, E.W. (author), Goeman, J.J. (author), Hulsman, M. (author), Emilsson, V. (author), Perola, M. (author), Willemsen, G. (author), Penninx, B.W.J.H. (author), Heijmans, B.T. (author), Maier, A.B. (author), Boomsma, D.I. (author), Kok, J.N. (author), Slagboom, P.E. (author), Reinders, M.J.T. (author), Beekman, M. (author)The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network-based approach for combining multiple...journal article 2013
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Schipper, H.R. (author), Grünewald, S. (author), Kok, M.A.D. (author), Nijsse, R. (author), Raghunath, P. (author)In an earlier article (CPI issue of August 2011 [1]) a method was presented for producing precast curved panels with a thickness of a few centimeters using the 'flexible mould method'. This method is the central theme in the PhD study of the first author on the realization of freeform architecture in concrete. The concrete panels manufactured...journal article 2013
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Overkamp, W. (author), Beilharz, K. (author), Detert Oude Weme, R. (author), Solopova, A. (author), Karsens, H. (author), Kovács, A.T. (author), Kok, J. (author), Kuipers, O.P (author), Veening, J.W. (author)Green fluorescent protein (GFP) offers efficient ways of visualizing promoter activity and protein localization in vivo, and many different variants are currently available to study bacterial cell biology. Which of these variants is best suited for a certain bacterial strain, goal, or experimental condition is not clear. Here, we have designed...journal article 2013
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Spekkers, M.H. (author), Kok, M. (author), Clemens, F.H.L.R. (author), Ten Veldhuis, J.A.E. (author)In this paper, a database of water-related insurance damage claims related to private properties and content was analysed. The aim was to investigate whether the probability of occurrence of rainfall-related damage was associated with the intensity of rainfall. Rainfall data were used for the period of 2003–2009 in the Netherlands based on a...journal article 2013
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Spekkers, M.H. (author), Kok, M. (author), Clemens, F.H.L.R. (author), Ten Veldhuis, J.A.E. (author)In this paper, a database of water-related insurance damage claims related to private properties and content was analysed. The aim was to investigate whether high numbers of damage claims were associated with high rainfall intensities. Rainfall data were used for the period of 2003–2010 in the Netherlands based on a network of 33 automatic rain...journal article 2012
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Jonkman, S.N. (author), Kok, M. (author)De recente overstromingen in het buitenland (New Orleans, Thailand, Japan en New York) laten zien hoe groot de maatschappelijke ontwrichting na een overstroming is en wat het belang van een goed waterkeringssysteem is. Hoewel Nederland één van de best beveiligde delta’s in de wereld is, voldoet een derde van onze hoofdwaterkeringen niet aan onze...journal article 2012
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De Jong, A. (author), Pietersma, H. (author), Cordes, M. (author), Kuipers, O.P. (author), Kok, J. (author)Background: Accurate prediction of DNA motifs that are targets of RNA polymerases, sigma factors and transcription factors (TFs) in prokaryotes is a difficult mission mainly due to as yet undiscovered features in DNA sequences or structures in promoter regions. Improved prediction and comparison algorithms are currently available for identifying...journal article 2012