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Gülcher, Oskar J. (author), Vis, Annemijn (author), Peirlinck, M. (author), Kluin, Jolanda (author)Background: Maintaining balanced left and right cardiac outputs in a total artificial heart (TAH) is challenging due to the need for continuous adaptation to changing hemodynamic conditions. Proper balance in ventricular outputs of the left and right ventricles requires a preload-sensitive response and mechanisms to address the higher...review 2023
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Gil Jimenez, A. (author), van Dorp, Jeroen (author), Contreras-Sanz, Alberto (author), van der Vos, Kristan (author), Vis, Daniel J. (author), Braaf, Linde (author), Broeks, Annegien (author), Alcaraz, Antonio (author), Wessels, L.F.A. (author)The authors regret that the following statement regarding author contributions was missed: Kristan van der Vos is currently a Scientific Editor for Cell Reports Medicine, which is published by Elsevier. Dr van der Vos was not involved in the peer-review process or editorial discussions about this manuscript. The authors would like to...journal article 2023
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Gil Jimenez, A. (author), van Dorp, Jeroen (author), Contreras-Sanz, Alberto (author), van der Vos, Kristan (author), Vis, Daniel J. (author), Braaf, Linde (author), Broeks, Annegien (author), Kerkhoven, Ron (author), van Kessel, Kim E.M. (author), Wessels, L.F.A. (author)Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy is recommended for patients with muscle-invasive bladder cancer (MIBC). It has been shown that somatic deleterious mutations in ERCC2, gain-of-function mutations in ERBB2, and alterations in ATM, RB1, and FANCC are correlated with pathological response to NAC in...journal article 2023
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Jaaks, Patricia (author), Coker, Elizabeth A. (author), Vis, Daniel J. (author), Edwards, Olivia (author), Carpenter, Emma F. (author), Leto, Simonetta M. (author), Dwane, Lisa (author), Sassi, Francesco (author), Wessels, L.F.A. (author)Combinations of anti-cancer drugs can overcome resistance and provide new treatments<sup>1,2</sup>. The number of possible drug combinations vastly exceeds what could be tested clinically. Efforts to systematically identify active combinations and the tissues and molecular contexts in which they are most effective could accelerate the...journal article 2022
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Gijsen, F.J.H. (author), Vis, Bas (author), Barrett, Hilary E. (author), Zadpoor, A.A. (author), Verhagen, Hence J. (author), Bos, Daniel (author), van der Steen, A.F.W. (author), Akyildiz, A.C. (author)Objective: Atherosclerotic plaque rupture in carotid arteries is a major source of cerebrovascular events. Calcifications are highly prevalent in carotid plaques, but their role in plaque rupture remains poorly understood. This work studied the morphometric features of calcifications in carotid plaques and their effect on the stress...journal article 2021
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Schouten, Philip C. (author), Richters, Lisa (author), Vis, Daniel J. (author), Kommoss, Stefan (author), Kluin, Roelof J.C. (author), Lips, Esther H. (author), Schmidt, Sandra (author), Nederlof, Petra M. (author), Wessels, L.F.A. (author)Purpose: Previously, we developed breast cancer BRCA1-like and BRCA2-like copy-number profile shrunken centroid classifiers predictive for mutation status and response to therapy, targeting homologous recombination deficiency (HRD). Therefore, we investigated BRCA1- and BRCA2-like classification in ovarian cancer, aiming to acquire...journal article 2021
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Dijk, Nick van (author), Gil Jimenez, A. (author), Silina, Karina (author), Montfoort, Maurits L.van (author), Einerhand, Sarah (author), Jonkman, Lars (author), Voskuilen, Charlotte S. (author), Vis, Daniel J. (author), Wessels, L.F.A. (author)Candidate immune biomarkers have been proposed for predicting response to immunotherapy in urothelial cancer (UC). Yet, these biomarkers are imperfect and lack predictive power. A comprehensive overview of the tumor immune contexture, including Tertiary Lymphoid structures (TLS), is needed to better understand the immunotherapy response in UC...journal article 2021
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van der Vos, K.E. (author), Vis, D.J. (author), Nevedomskaya, E. (author), Kim, Y. (author), Choi, W. (author), McConkey, D. (author), Wessels, L.F.A. (author), van Rhijn, B.W.G. (author), Zwart, W. (author), van der Heijden, M.S. (author)Muscle-invasive bladder cancer (MIBC) is a heterogeneous disease that often recurs despite aggressive treatment with neoadjuvant chemotherapy and (radical) cystectomy. Basal and luminal molecular subtypes have been identified that are linked to clinical characteristics and have differential sensitivities to chemotherapy. While it has been...journal article 2020
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Kim, Yongsoo (author), Bismeijer, Tycho (author), Zwart, Wilbert (author), Wessels, L.F.A. (author), Vis, Daniel J. (author)Integrative analyses that summarize and link molecular data to treatment sensitivity are crucial to capture the biological complexity which is essential to further precision medicine. We introduce Weighted Orthogonal Nonnegative parallel factor analysis (WON-PARAFAC), a data integration method that identifies sparse and interpretable factors....journal article 2019
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Edmunds, Laurel D. (author), Gluderer, Silvia (author), Ovseiko, Pavel V. (author), Kamerling, R. (author), Ton, Jacqueline (author), Vis, Laura (author), Jenni, Mario (author), Tutton, Gregory (author), Lawton-Smith, Helen (author)Background: While the European Union is striving to become the 'Innovation Union', there remains a lack of quantifiable indicators to compare and benchmark regional innovation clusters. To address this issue, a HealthTIES (Healthcare, Technology and Innovation for Economic Success) consortium was funded by the European Union's Regions of...journal article 2019
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Barthel, Stephan (author), Isendahl, Christian (author), Vis, Benjamin N. (author), Drescher, Axel (author), Evans, Daniel L. (author), van Timmeren, A. (author)Global urbanization and food production are in direct competition for land. This paper carries out a critical review of how displacing crop production from urban and peri-urban land to other areas – because of issues related to soil quality – will demand a substantially larger proportion of the Earth’s terrestrial land surface than the...journal article 2019
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Iorio, Francesco (author), Knijnenburg, Theo A. (author), Vis, Daniel J. (author), Bignell, Graham R. (author), Menden, Michael P. (author), Schubert, Michael (author), Aben, N.N. (author), Gonçalves, Emanuel (author), Barthorpe, Syd (author), Wessels, L.F.A. (author)Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature of cancer. Using this information to guide the development and application of therapies in the clinic is challenging. Here, we report how cancerdriven alterations identified in 11,289 tumors from 29 tissues (integrating somatic mutations, copy...journal article 2016
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Aben, N.N. (author), Vis, Daniel J. (author), Michaut, Magali (author), Wessels, L.F.A. (author)Motivation: Clinical response to anti-cancer drugs varies between patients. A large portion of this variation can be explained by differences in molecular features, such as mutation status, copy number alterations, methylation and gene expression profiles. We show that the classic approach for combining these molecular features (Elastic Net...journal article 2016
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- Bertotti, G. (author), Bisdom, K. (author), Van Eijk, M. (author), Hameka, F. (author), Vis, A. (author), Bezerra, H. (author), Reijmer, J. (author) conference paper 2014
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Van Rijn, J.N. (author), Vis, J.K. (author)Dou Shou Qi is a game in which players control a number of pieces, aiming to move one of these onto a certain square. We will present a proof showing that this game is PSPACE-hard. Furthermore, we have implemented an analyzing engine and created an endgame tablebase containing all configurations with up to four pieces. These are the first steps...conference paper 2013
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- Simonse, W.L. (author), Vis, S. (author), Griffioen, E. (author), Nino, L. (author), Ruiz, C. (author), Crossley Urrego, A. (author), Soto Camacho, G. (author) conference paper 2012
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- Sadacharan, D. (author), Marchand, M. (author), Vis, M. (author) report 2003
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- Sadacharan, D. (author), Marchand, M. (author), Vis, M. (author) report 2003
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- van Staalduinen, P.C. (author), Gijsbers, F.B.J. (author), Vis, R. (author), Middeldorp, F.M. (author) report 1999
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- Vis, M. (author), Vries, M.B. (author) report 1998
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