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Jennings, L. (author), Ivashchenko, O. (author), Marsman, I. J C (author), Laan, A.C. (author), Denkova, A.G. (author), Waton, G. (author), Beekman, F.J. (author), Schosseler, F. (author), Mendes, E. (author)
Understanding how nanoparticle properties such as size, morphology and rigidity influence their circulation time and biodistribution is essential for the development of nanomedicine therapies. Herein we assess the influence of morphology on cellular internalization, in vivo biodistribution and circulation time of nanocarriers using...
journal article 2016
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Arranja, Alexandra (author), Ivashchenko, O. (author), Denkova, A.G. (author), Morawska, K.M. (author), Van Vlierberghe, Sandra (author), Dubruel, Peter (author), Waton, Gilles (author), Beekman, F.J. (author), Schosseler, François (author), Mendes, E. (author)
Optimal biodistribution and prolonged circulation of nanocarriers improve diagnostic and therapeutic effects of enhanced permeability and retention-based nanomedicines. Despite extensive use of Pluronics in polymer-based pharmaceuticals, the influence of different poly(ethylene oxide) (PEO) block length and aggregation state on the...
journal article 2016