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Driessen, Helen P.A. (author), Busschbach, Jan J.V. (author), Van Der Rijt, Carin C.D. (author), Elfrink, Erna J. (author), Raijmakers, Natasja J.H. (author), Van Roij, Janneke (author), Rietjens, J.A.C. (author), Kranenburg, Leonieke W. (author)Objectives: The care needs of patients with advanced cancer and their relatives change throughout the disease trajectory. This study focused on the care-related problems and needs of patients with advanced cancer and their relatives. This was done from the perspective of centres for information and support. Methods: This cross-sectional study...journal article 2023
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Ju, Jie (author), Wismans, Leonoor V. (author), Mustafa, Dana A.M. (author), Reinders, M.J.T. (author), van Eijck, Casper H.J. (author), Li, Yunlei (author)A major challenge for treating patients with pancreatic ductal adenocarcinoma (PDAC) is the unpredictability of their prognoses due to high heterogeneity. We present Multi-Omics DEep Learning for Prognosis-correlated subtyping (MODEL-P) to identify PDAC subtypes and to predict prognoses of new patients. MODEL-P was trained on autoencoder...journal article 2021
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Bloemberg, J. (author), Van Riel, Luigi (author), Dodou, D. (author), Breedveld, P. (author)Introduction: Conventional cancer treatments such as radical surgery and systemic therapy targeting the organ or organ system might have side effects because of damage to the surrounding tissue. For this reason, there is a need for new instruments that focally treat cancer. Areas covered: This review provides a comprehensive overview of the...review 2021
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Taskesen, E. (author), Huisman, S.M.H. (author), Mahfouz, A.M.E.T.A. (author), Krijthe, J.H. (author), de Ridder, J. (author), van de Stolpe, A. (author), van den Akker, E.B. (author), Verhaegh, Wim (author), Reinders, M.J.T. (author)The use of genome-wide data in cancer research, for the identification of groups of patients with similar molecular characteristics, has become a standard approach for applications in therapy-response, prognosis-prediction, and drug-development. To progress in these applications, the trend is to move from single genome-wide measurements in a...journal article 2016
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Marien, Eyra (author), Meister, Michael (author), Muley, Thomas (author), del Pulgar, Teresa Gomez (author), Derua, Rita (author), Spraggins, Jeffrey M. (author), Van de Plas, Raf (author), Vanderhoydonc, Frank (author), Machiels, Jelle (author), Binda, Maria Mercedes (author), Dehairs, Jonas (author), Willette-Brown, Jami (author), Hu, Yinling (author), Dienemann, Hendrik (author), Thomas, Michael (author), Schnabe, Philipp A. (author), Caprioli, Richard M. (author), Lacal, Juan Carlos (author), Waelkens, Etienne (author), Swinnen, Johannes V. (author)Lung cancer is the leading cause of cancer death. Beyond first line treatment, few therapeutic options are available, particularly for squamous cell carcinoma (SCC). Here, we have explored the phospholipidomes of 30 human SCCs and found that they almost invariably (in 96.7% of cases) contain phospholipids with longer acyl chains compared to...journal article 2016