document

Accelerated discovery of functional genomic variation in pigs

Derks, Martijn F.L. (author), Groß, C. (author), Lopes, Marcos S. (author), Reinders, M.J.T. (author), Bosse, Mirte (author), Gjuvsland, Arne B. (author), de Ridder, Dick (author), Megens, Hendrik-Jan (author), Groenen, Martien A.M. (author)

The genotype-phenotype link is a major research topic in the life sciences but remains highly complex to disentangle. Part of the complexity arises from the number of genes contributing to the observed phenotype. Despite the vast increase of molecular data, pinpointing the causal variant underlying a phenotype of interest is still challenging...

journal article 2021

document

PCADD: SNV prioritisation in Sus scrofa

Groß, C. (author), Derks, Martijn (author), Megens, Hendrik Jan (author), Bosse, Mirte (author), Groenen, Martien A.M. (author), Reinders, M.J.T. (author), de Ridder, D. (author)

Background: In animal breeding, identification of causative genetic variants is of major importance and high economical value. Usually, the number of candidate variants exceeds the number of variants that can be validated. One way of prioritizing probable candidates is by evaluating their potential to have a deleterious effect, e.g. by...

journal article 2020

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A survey of functional genomic variation in domesticated chickens

Derks, Martijn F.L. (author), Megens, Hendrik-Jan (author), Bosse, Mirte (author), Visscher, Jeroen (author), Peeters, Katrijn (author), Bink, Marco C.A.M. (author), Vereijken, Addie (author), Groß, C. (author), de Ridder, D. (author), Reinders, M.J.T. (author), Groenen, Martien A.M. (author)

Background: Deleterious genetic variation can increase in frequency as a result of mutations, genetic drift, and genetic hitchhiking. Although individual effects are often small, the cumulative effect of deleterious genetic variation can impact population fitness substantially. In this study, we examined the genome of commercial purebred chicken...

journal article 2018

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A microfluidic AFM cantilever based dispensing and aspiration platform

Van Oorschot, R. (author), Perez Garza, H.H. (author), Derks, R.J.S. (author), Staufer, U. (author), Ghatkesar, M.K. (author)

We present the development of a microfluidic AFM (atomic force microscope) cantilever-based platform to enable the local dispensing and aspiration of liquid with volumes in the pico-to-femtoliter range. The platform consists of a basic AFM measurement system, microfluidic AFM chip, fluidic interface, automated substrate alignment, external...

journal article 2015

document

Improving project and resource planning within Frames Process Systems (summary)

Derks, M. (author)

master thesis 2010

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Improving project and resource planning within Frames Process Systems

Derks, M. (author)

master thesis 2010

document

Onderhoud systeemkundig benaderd. Een beschouwing van RCM en TPM

Derks, M. (author)

report 2009

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Onderhoud systeemkundig benaderd. Een beschouwing van RCM en TPM (summary)

Derks, M. (author)

report 2009

document

Laplacian Instability of Planar Streamer Ionization Fronts: An Example of Pulled Front Analysis

Derks, G. (author), Ebert, U. (author), Meulenbroek, B. (author)

Streamer ionization fronts are pulled fronts that propagate into a linearly unstable state; the spatial decay of the initial condition of a planar front selects dynamically one specific long-time attractor out of a continuous family. A stability analysis for perturbations in the transverse direction has to take these features into account. In...

journal article 2008

document

Noordzee 2050: Beleidstypen voor sturing van ruimtedruk

Derks, G.H.E. (author), Duenk, F.H.J. (author)

Met het oog op de vernieuwing van het waterbeleid is door Rijkswaterstaat het onderzoeksprogramma Waterverkenningen gestart. Onderdeel hiervan vormt de Kustzoneverkenning. Dit project verkent door prikkelende studies van min of meer extreme situaties de kansen en knelpunten voor het beleid in een brede kustzone. Doel is vooral het inspireren van...

report 2001

document

Cold fluid driven crack propagation: Thermo-mechanical behaviour of rock caverns

Derks, J.P.B.N. (author)

doctoral thesis 1997

document

De Merwede

Derks, B. (author), Daman, B. (author)

master thesis 1995

document

Gedrag van asfaltbekleding onder golfaanval: Verslag modelonderzoek in Deltagoot

Derks, H. (author), Klein Breteler, M. (author)

report 1992

document

The Egmond field data and their use for the validation of mathematical models

De Vriend, H.J. (author), Reinalda, R. (author), Derks, H. (author)

The 1981 and 1982/1983 field measurement campaigns in the nearshore zone at Egmond, The Netherlands, are outlined and the access to the resulting data sets is indicated. Besides, the use of these data for mathematical model validation is discussed and some general remarks are made on the set-up of synoptic field campaigns to generate data sets...

report 1987

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Praktijkproef met Enkamatten in het Grevelingenmeer 1974-1985

Derks, H. (author)

report 1985

document

Design and model tests in relation with the mixture formation in a dredge wheel. Tweede 5de-jaars opdracht. Zie CO/83/143

Derks, J.C.M. (author)

report 1984

document

An alternative design of a dredge wheel for the excavation of sand and cohesive soils

Derks, J.C.M. (author)

master thesis 1984

document

Natuurmetingen aan de kust te Egmond in mei en juni 1981: Inrichting en gebruik van de meetopstelling en kosten

Derks, H. (author), Kos, T. (author), Moritz, H.C. (author)

report 1983

document

Natuurmetingen aan de kust te Egmond van september 1982 tot januari 1983: Meetseries 0000 en 1000 : metingen ten behoeve van onderzoek bruikbaarheid meetinstrumenten

Derks, H. (author)

report 1983

document

Natuurmetingen aan de kust te Egmond van september 1982 tot januari 1983: Inrichting en gebruik van de meetopstelling en kosten

Derks, H. (author), Kos, T. (author), Moritz, H.C. (author)

report 1983