An additive manufacturing filter for topology optimization of print-ready designs

Additive manufacturing (AM) offers exciting opportunities to manufacture parts of unprecedented complexity. Topology optimization is essential to fully exploit this capability. However, AM processes have specific limitations as well. When these are not considered during design optimization, modifications are generally needed in post...

Analytical relationships for the mechanical properties of additively manufactured porous biomaterials based on octahedral unit cells

Additively manufacturing (AM) techniques make it possible to fabricate open-cell interconnected structures with precisely controllable micro-architectures. It has been shown that the morphology, pore size, and relative density of a porous structure determine its macro-scale homogenized mechanical properties and, thus, its biological performance...

How does tissue regeneration influence the mechanical behavior of additively manufactured porous biomaterials?

Although the initial mechanical properties of additively manufactured porous biomaterials are intensively studied during the last few years, almost no information is available regarding the evolution of the mechanical properties of implant-bone complex as the tissue regeneration progresses. In this paper, we studied the effects of tissue...

A simulator-assisted workshop for teaching chemostat cultivation in academic classes on microbial physiology

Understanding microbial growth and metabolism is a key learning objective of microbiology and biotechnology courses, essential for understanding microbial ecology, microbial biotechnology and medical microbiology. Chemostat cultivation, a key research tool in microbial physiology that enables quantitative analysis of growth and metabolism under...

Additively manufactured biodegradable porous magnesium

An ideal bone substituting material should be bone-mimicking in terms of mechanical properties, present a precisely controlled and fully interconnected porous structure, and degrade in the human body to allow for full regeneration of large bony defects. However, simultaneously satisfying all these three requirements has so far been highly...

Additive manufacturing for circular product design: A literature review from a design perspective

Circular product design is a relatively new approach to design suitable strategies to realize circular products. Additive manufacturing (AM) is seen as a promising enabling production process. It has digital and additive characteristics, which makes AM different from conventional production techniques. However, it is yet unclear how this...

Fatigue crack propagation in additively manufactured porous biomaterials

Additively manufactured porous titanium implants, in addition to preserving the excellent biocompatible properties of titanium, have very small stiffness values comparable to those of natural bones. Although usually loaded in compression, biomedical implants can also be under tensional, shear, and bending loads which leads to crack initiation...

A micromechanical approach To numerical modeling of yielding of open-cell porous structures under compressive loads

Today, interconnected open-cell porous structures made of titanium and its alloys are replacing the prevalent solid metals used in bone substitute implants. The advent of additive manufacturing techniques has enabled manufacturing of open-cell structures with arbitrary micro-structural geometry. In this paper, rhombic dodecahedron structures...

Computational prediction of the fatigue behavior of additively manufactured porous metallic biomaterials

The mechanical behavior of additively manufactured porous biomaterials has recently received increasing attention. While there is a relatively large body of data available on the static mechanical properties of such biomaterials, their fatigue behavior is not yet well-understood. That is partly because systematic study of the fatigue behavior...

Topology optimization of 3D self-supporting structures for additive manufacturing

The potential of topology optimization to amplify the benefits of additive manufacturing (AM), by fully exploiting the vast design space that AM allows, is widely recognized. However, existing topology optimization approaches do not consider AM-specific limitations during the design process, resulting in designs that are not self-supporting....