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Chen, J. (author)Cancer is known as one of the leading causes of death in the world with difficult<br/>diagnose at early stages, poor prognosis and high mortality. Animal-based<br/>experiments and clinical trials have always been the main approach for cancer<br/>research, albeit they may have limitations and ethical issues. Mathematicalmodeling<br/>as an...doctoral thesis 2020
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Chen, J. (author), Weihs, Daphne (author), Vermolen, F.J. (author)More than eighty percent of pancreatic cancer involves ductal adenocarcinoma with an abundant desmoplastic extracellular matrix surrounding the solid tumor entity. This aberrant tumor microenvironment facilitates a strong resistance of pancreatic cancer to medication. Although various therapeutic strategies have been reported to be effective...journal article 2019