Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles

Nanoparticles are ultrafine particulate matter having considerable potential for treatment of central nervous system (CNS) disorders. Despite their tiny size, the blood-brain barrier (BBB) restricts their access to the CNS. Their direct cerebrospinal fluid (CSF) administration bypasses the BBB endothelium, but still fails to give adequate...

CRI-SPA: a high-throughput method for systematic genetic editing of yeast libraries

Biological functions are orchestrated by intricate networks of interacting genetic elements. Predicting the interaction landscape remains a challenge for systems biology and new research tools allowing simple and rapid mapping of sequence to function are desirable. Here, we describe CRI-SPA, a method allowing the transfer of chromosomal...

Genotoxicity in the absence of inflammation after tungsten inhalation in mice

Tungsten is used in several applications and human exposure may occur. To assess its pulmonary toxicity, we exposed male mice to nose-only inhalation of tungsten particles at 9, 23 or 132 mg/m³ (Low, Mid and High exposure) (45 min/day, 5 days/week for 2 weeks). Increased genotoxicity (assessed by comet assay) was seen in...

Pulmonary toxicity of molybdenum disulphide after inhalation in mice

Molybdenum disulphide (MoS₂) is a constituent of many products. To protect humans, it is important to know at what air concentrations it becomes toxic. For this, we tested MoS₂ particles by nose-only inhalation in mice. Exposures were set to 13, 50 and 150 mg MoS₂/m³ (=8, 30 and 90 mg Mo/m<sup>3<...

Ambient seismic noise monitoring and imaging at the Theistareykir geothermal field (Iceland)

In autumn 2017 a network of 14 broadband seismic stations was deployed at the Theistareykir high temperature geothermal field (NE Iceland). This experiment was conducted as part of the current efforts to characterize the field's main structures, and possible short and long term stress variations due to the ongoing fluid injection and...

The microscopic distribution of hydrophilic polymers in interpenetrating polymer networks (IPNs) of medical grade silicone

By introducing hydrophilic polymers into silicone medical devices, highly beneficial biomedical properties can be realized. An established solution to introduce hydrophilic polymers is to form an interpenetrating polymer network (IPN) by performing the hydrogel synthesis in the presence of silicone swollen in supercritical carbon dioxide. The...

A framework for indicator-based reporting on sustainable consumption and production

The policy area of sustainable consumption and production (SCP) takes a holistic perspective on how society and the economy can be changed and better aligned with the goals of sustainability. This paper presents a framework developed for the selection of Indicators for use by the European Environment Agency (EEA) for assessing and reporting on...

Dynamics of prolate ellipsoidal particles in a turbulent channel flow

The dynamical behavior of tiny elongated particles in a directly simulated turbulent flow field is investigated. The ellipsoidal particles are affected both by inertia and hydrodynamic forces and torques. The time evolution of the particle orientation and translational and rotational motions in a statistically steady channel flow is obtained for...

Fibre-induced drag reduction

We use direct numerical simulation to study turbulent drag reduction by rigid polymer additives, referred to as fibres. The simulations agree with experimental data from the literature in terms of friction factor dependence on Reynolds number and fibre concentration. An expression for drag reduction is derived by adopting the concept of the...

The stress generated by non-Brownian fibers in turbulent channel flow simulations

Turbulent fiber suspension channel flow is studied using direct numerical simulation. The effect of the fibers on the fluid mechanics is governed by a stress tensor, involving the distribution of fiber position and orientation. Properties of this function in channel flow are studied by computing the trajectories and orientations of individual...

Particle spin in a turbulent shear flow

The translational and rotational motions of small spherical particles dilutely suspended in a turbulent channel flow have been investigated. Three different particle classes were studied in an Eulerian-Lagrangian framework to examine the effect of the response times on the particle statistics. The results for the fluctuating particle velocities...

On the performance of the moment approximation for the numerical computation of fiber stress in turbulent channel flow

Fiber-induced drag reduction can be studied in great detail by means of direct numerical simulation [ J. S. Paschkewitz et al., J. Fluid Mech. 518, 281 (2004) ]. To account for the effect of the fibers, the Navier-Stokes equations are supplemented by the fiber stress tensor, which depends on the distribution function of fiber orientation angles....