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Su, R. (author), van der Sluijs, P.M. (author), Chen, Yuan (author), Cornelissen, Sandra (author), van den Broek, R.B. (author), van Zwam, Wim H. (author), van der Lugt, Aad (author), Niessen, W.J. (author), Ruijters, Danny (author), van Walsum, T. (author)Cerebral X-ray digital subtraction angiography (DSA) is a widely used imaging technique in patients with neurovascular disease, allowing for vessel and flow visualization with high spatio-temporal resolution. Automatic artery–vein segmentation in DSA plays a fundamental role in vascular analysis with quantitative biomarker extraction,...journal article 2024
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Abler, Daniel (author), Schaer, Roger (author), Oreiller, Valentin (author), Verma, H. (author), Reichenbach, Julien (author), Aidonopoulos, Orfeas (author), Evéquoz, Florian (author), Jreige, Mario (author), Prior, John (author)Background: Radiomics, the field of image-based computational medical biomarker research, has experienced rapid growth over the past decade due to its potential to revolutionize the development of personalized decision support models. However, despite its research momentum and important advances toward methodological standardization, the...journal article 2023
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Tourais, Joao (author), Ploem, T.W. (author), Zadelhoff, Tijmen A.van (author), Steeg-Henzen, Christal van de (author), Oei, Edwin H.G. (author), Weingärtner, S.D. (author)Objective: Quantitative Magnetic Resonance Imaging (MRI) holds great promise for the early detection of cartilage deterioration. Here, a Magnetic Resonance Fingerprinting (MRF) framework is proposed for comprehensive and rapid quantification of T <sub>1</sub>, T <sub>2</sub> <sup>∗</sup>, and T <sub>RAFF2</sub> with whole-knee coverage....journal article 2023
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Perinajová, R. (author), Álvarez-Cuevas, Concepción Borrás (author), Juffermans, Joe (author), Westenberg, Jos (author), Lamb, Hildo (author), Kenjeres, S. (author)There is a pressing need to establish novel biomarkers to predict the progression of thoracic aortic aneurysm (TAA) dilatation. Aside from hemodynamics, the roles of oxygen (O<sub>2</sub>) and nitric oxide (NO) in TAA pathogenesis are potentially significant. As such, it is imperative to comprehend the relationship between aneurysm presence...journal article 2023
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Starmans, Martijn P.A. (author), Buisman, Florian E. (author), Renckens, Michel (author), Willemssen, François E.J.A. (author), van der Voort, Sebastian R. (author), Groot Koerkamp, B. (author), Grünhagen, Dirk J. (author), Niessen, W.J. (author), Vermeulen, Peter B. (author)Histopathological growth patterns (HGPs) are independent prognosticators for colorectal liver metastases (CRLM). Currently, HGPs are determined postoperatively. In this study, we evaluated radiomics for preoperative prediction of HGPs on computed tomography (CT), and its robustness to segmentation and acquisition variations. Patients with...journal article 2021
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Vrieling, Frank (author), Ronacher, Katharina (author), Kleynhans, Léanie (author), van den Akker, E.B. (author), Walzl, Gerhard (author), Ottenhoff, Tom H.M. (author), Joosten, Simone A. (author)Background: Type 2 diabetes mellitus (DM) is a major risk factor for development of tuberculosis (TB), however the underlying molecular foundations are unclear. Since lipids play a central role in the development of both DM and TB, lipid metabolism may be important for TB-DM pathophysiology. Methods: A <sup>1</sup> H NMR spectroscopy-based...journal article 2018
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Weeber, Fleur (author), Cirkel, Geert A. (author), Hoogstraat, Marlous (author), Bins, Sander (author), Gadellaa-van Hooijdonk, Christa G.M. (author), Ooft, Salo (author), van Werkhoven, Erik (author), Willems, Stefan M. (author), van Stralen, Marijn (author), Veldhuis, Wouter B. (author), Besselink, Nicolle J.M. (author), Horlings, Hugo M. (author), Steeghs, Neeltje (author), de Jonge, Maja J. (author), Langenberg, Marlies H.G. (author), Wessels, L.F.A. (author), Cuppen, Edwin (author), Cuppen, Edwin (author), Schellens, J.H. (author), Sleijfer, Stefan (author), Lolkema, Martijn P. (author), Voest, Emile E. (author)Background: In this study, our aim was to identify molecular aberrations predictive for response to everolimus, an mTOR inhibitor, regardless of tumor type. Methods: To generate hypotheses about potential markers for sensitivity to mTOR inhibition, drug sensitivity and genomic profiles of 835 cell lines were analyzed. Subsequently, a...journal article 2017