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- Klein, M. (author), Bera, Subhas C. (author), Anderson, Thomas K. (author), Wang, Bing (author), Papini, Flavia S. (author), Arnold, Jamie J. (author), Cameron, Craig E. (author), Depken, S.M. (author), Dulin, D. (author) journal article 2023
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Bera, Subhas C. (author), America, Pim P.B. (author), Maatsola, Santeri (author), Seifert, Mona (author), Ostrofet, Eugeniu (author), Cnossen, J.P. (author), Spermann, Monika (author), Depken, S.M. (author), Dulin, D. (author)Transcription initiation is the first step in gene expression, and is therefore strongly regulated in all domains of life. The RNA polymerase (RNAP) first associates with the initiation factor σ to form a holoenzyme, which binds, bends and opens the promoter in a succession of reversible states. These states are critical for transcription...journal article 2022
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Seifert, Mona (author), Bera, Subhas C. (author), van Nies, Pauline (author), Kirchdoerfer, Robert N. (author), Shannon, Ashleigh (author), Le, Thi Tuyet Nhung (author), Meng, Xiangzhi (author), Depken, S.M. (author), Dulin, David (author)The absence of 'shovel-ready' anti-coronavirus drugs during vaccine development has exceedingly worsened the SARS-CoV-2 pandemic. Furthermore, new vaccine-resistant variants and coronavirus outbreaks may occur in the near future, and we must be ready to face this possibility. However, efficient antiviral drugs are still lacking to this day,...journal article 2021