Genotoxicity in the absence of inflammation after tungsten inhalation in mice

Tungsten is used in several applications and human exposure may occur. To assess its pulmonary toxicity, we exposed male mice to nose-only inhalation of tungsten particles at 9, 23 or 132 mg/m³ (Low, Mid and High exposure) (45 min/day, 5 days/week for 2 weeks). Increased genotoxicity (assessed by comet assay) was seen in...

Pulmonary toxicity of molybdenum disulphide after inhalation in mice

Molybdenum disulphide (MoS₂) is a constituent of many products. To protect humans, it is important to know at what air concentrations it becomes toxic. For this, we tested MoS₂ particles by nose-only inhalation in mice. Exposures were set to 13, 50 and 150 mg MoS₂/m³ (=8, 30 and 90 mg Mo/m<sup>3<...