Douma, R.D. (author), Batista, J.M. (author), Touw, K.M. (author), Kiel, J.A.K.W. (author), Krikken, A.M. (author), Zhao, Z. (author), Veiga, T. (author), Klaassen, P. (author), Bovenberg, R.A.L. (author), Daran, J.M. (author), Heijnen, J.J. (author), Van Gulik, W.M. (author) Background In microbial production of non-catabolic products such as antibiotics a loss of production capacity upon long-term cultivation (for example chemostat), a phenomenon called strain degeneration, is often observed. In this study a systems biology approach, monitoring changes from gene to produced flux, was used to study degeneration of...
journal article 2011
