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Cecotto, Leonardo (author), Stapels, Daphne A.C. (author), van Kessel, Kok P.M. (author), Croes, Michiel (author), Lourens, Zeldali (author), Vogely, H. Charles (author), van der Wal, Bart C.H. (author), van Strijp, Jos A.G. (author), Weinans, Harrie (author), Amin Yavari, Saber (author)Background: Despite the extensive use of silver ions or nanoparticles in research related to preventing implant-associated infections (IAI), their use in clinical practice has been debated. This is because the strong antibacterial properties of silver are counterbalanced by adverse effects on host cells. One of the reasons for this may be the...journal article 2023
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Cecotto, Leonardo (author), van Kessel, Kok (author), Wolfert, Margreet A. (author), Vogely, Charles (author), van der Wal, Bart (author), Weinans, Harrie (author), van Strijp, Jos (author), Amin Yavari, S. (author)Cationic host defense peptides (HDPs) are a promising alternative to antibiotics in the fight against Staphylococcus aureus infections. In this study, we investigated the antibacterial and immunomodulatory properties of three HDPs namely IDR-1018, CATH-2, and LL-37. Although all three HDPs significantly inhibited LPS-induced activation of...journal article 2022