SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture

Background: Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. The aim of this study was to evaluate their co-existing prevalence in human carotid plaques with respect to plaque phenotype to determine the value of hybrid imaging for the detection of these biomarkers....

Imaging of inflammatory cellular protagonists in human atherosclerosis: a dual-isotope SPECT approach

Purpose: Atherosclerotic plaque development and progression signifies a complex inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using single photon emission computed tomography (SPECT) coupled with computed tomography (CT), this study tested a new dual-isotope acquisition protocol to assess each radiotracer...

Innovation opportunities for academic libraries to support teaching through open education: A case study at TU Delft, the Netherlands

Opportunities for academic libraries to enrich their products and services through facilitating open education (OE) in higher education are presented in an overview of good practices. A case study of open textbook publishing was performed at TU Delft to study how these products and services could stimulate educators to adopt OE. A simplified...

Hydrographic and Biological Survey of a Surface-Intensified Anticyclonic Eddy in the Caribbean Sea

In the Caribbean Sea, mesoscale anticyclonic ocean eddies impact the local ecosystem by mixing of low salinity river outflow with the nutrient-rich waters upwelling along the Venezuelan and Colombian coast. To gain insight into the physics and the ecological impact of these anticyclones, we performed a combined hydrographic and biological...

A nitride-based epitaxial surface layer formed by ammonia treatment of silicene-terminated ZrB₂

We present a method for the formation of an epitaxial surface layer involving B, N, and Si atoms on a ZrB₂(0001) thin film on Si(111). It has the potential to be an insulating growth template for 2D semiconductors. The chemical reaction of NH₃ molecules with the silicene-terminated ZrB₂ surface was...

Utilizing high-energy γ-photons for high-resolution ²¹³Bi SPECT in mice

The combined α-, γ-, and x-ray emitter ²¹³Bi (half-life, 46 min) is promising for radionuclide therapy. SPECT imaging of ²¹³Bi is challenging, because most emitted photons have a much higher energy (440 keV) than common in SPECT. We assessed ²¹³Bi imaging capabilities of the Versatile Emission Computed...

Triamcinolone acetonide activates an anti-inflammatory and folate receptor–positive macrophage that prevents osteophytosis in vivo

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