Radiolabeling polymeric micelles for in vivo evaluation: A novel, fast, and facile method

Background Single photon emission computed tomography (SPECT) is an indispensable tool in the determination of the in vivo fate of polymeric micelles. However, for this purpose, the micelles need to be radiolabeled, and almost all radiolabeling procedures published to date involve the conjugation of a chelating agent to the constituting polymer,...

Electronic Origins of Anomalous Twin Boundary Energies in Hexagonal Close Packed Transition Metals

Density-functional-theory calculations of twin-boundary energies in hexagonal close packed metals reveal anomalously low values for elemental Tc and Re, which can be lowered further by alloying with solutes that reduce the electron per atom ratio. The anomalous behavior is linked to atomic geometries in the interface similar to those observed in...

Charting the complete elastic properties of inorganic crystalline compounds

Increased physical activity severely induces osteoarthritic changes in knee joints with papain induced sulfate-glycosaminoglycan depleted cartilage

Introduction Articular cartilage needs sulfated-glycosaminoglycans (sGAGs) to withstand high pressures while mechanically loaded. Chondrocyte sGAG synthesis is regulated by exposure to compressive forces. Moderate physical exercise is known to improve cartilage sGAG content and might protect against osteoarthritis (OA). This study investigated...

Can DCE-MRI explain the heterogeneity in radiopeptide uptake imaged by SPECT in a pancreatic neuroendocrine tumor model?

Although efficient delivery and distribution of treatment agents over the whole tumor is essential for successful tumor treatment, the distribution of most of these agents cannot be visualized. However, with single-photon emission computed tomography (SPECT), both delivery and uptake of radiolabeled peptides can be visualized in a neuroendocrine...

Efficiency enhancement calculations of state-of-the-art solar cells by luminescent layers with spectral shifting, quantum cutting, and quantum tripling function

Solar cells of which the efficiency is not limited by the Shockley-Queisser limit can be obtained by integrating a luminescent spectral conversion layer into the cell structure. We have calculated the maximum efficiency of state-of-the-art c-Si, pc-Si, a-Si, CdTe, GaAs, CIS, CIGS, CGS, GaSb, and Ge solar cells with and without an integrated...

Alternatieve benadering voor maatgevende waterstanden Nederlandse kust

Het stormseizoen is weer begonnen in Nederland. De duinen en dijken langs de Nederlandse kust kunnen in deze periode zwaar belast worden door een combinatie van hoge stormvloed en zware golven. Op dit moment worden deze waterkeringen getoetst en ontworpen met waterstandsgegevens die vooral gebaseerd zijn op statistische extrapolatie van...

Segmentation and visual analysis of whole-body mouse skeleton microSPECT

Whole-body SPECT small animal imaging is used to study cancer, and plays an important role in the development of new drugs. Comparing and exploring whole-body datasets can be a difficult and time-consuming task due to the inherent heterogeneity of the data (high volume/throughput, multi-modality, postural and positioning variability). The goal...

De discussie over transportmodellen

Dit artikel geeft een overzicht van de discussie over transportmodellen in Nederland zoals met name gevoerd in de periode 2007 - 2010. De kern van de discussie is dat transportmodellen zijn overvraagd en dat de inherente onzekerheden in modelresultaten ten onrechte zijn genegeerd. Er lijkt consensus in het debat om voortaan wel de onzekerheid in...

Facilitating tumor functional assessment by spatially relating 3D tumor histology and in vivo MRI: Image registration approach

Background Magnetic resonance imaging (MRI), together with histology, is widely used to diagnose and to monitor treatment in oncology. Spatial correspondence between these modalities provides information about the ability of MRI to characterize cancerous tissue. However, registration is complicated by deformations during pathological processing,...

A Typology of Strategic Behaviour in PPPs for Expressways: Lessons from China and Implications for Europe

In line with governance trends around the world, a growing number of expressways in the People’s Republic of China are managed as Public-Private Partnerships (PPPs). The tremendous growth in demand for mobility in newly emerging economies has led to a gap between investment needs and available public funding. Using private funds is potentially...