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Huan, Z. (author), Fratila-Apachitei, L.E. (author), Apachitei, I. (author), Duszczyk, J. (author)In this study, a porous oxide layer was formed on the surface of 316L stainless steel (SS) by combining Ti magnetron sputtering and plasma electrolytic oxidation (PEO) with the aim to produce a polymer-free drug carrier for drug eluting stent (DES) applications. The oxidation was performed galvanostatically in Na3PO4 electrolyte. The surface...journal article 2012
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Dawes, G.J.S. (author), Fratila-Apachitei, L.E. (author), Necula, B.S. (author), Apachitei, I. (author), Witkamp, G.J. (author), Duszczyk, J. (author)The aim of the present study was to investigate the morphology and function of a drug eluting metallic porous surface produced by the immobilization of poly lactide-co-glycolide microspheres bearing dexamethasone onto plasma electrolytically oxidized Ti–6Al–7Nb medical alloy. Spheres of 20 µm diameter were produced by an oilin-water emulsion...journal article 2009
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Dawes, G.J.S. (author), Fratila-Apachitei, L.E. (author), Mulia, K. (author), Apachitei, I. (author), Witkamp, G.J. (author), Duszczyk, J. (author)Drug delivery systems (DDS) based on poly (lactide-co-glycolide) (PLGA) microspheres and nanospheres have been separately studied in previous works as a means of delivering bioactive compounds over an extended period of time. In the present study, two DDS having different sizes of the PLGA spheres were compared in morphology, drug (dexamethasone...journal article 2009
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Necula, B.S. (author), Fratila-Apachitei, L.E. (author), Berkani, A. (author), Apachitei, I. (author), Duszczyk, J. (author)The growing fight against infections caused by bacteria poses new challenges for development of materials and medical devices with antimicrobial properties. Silver is a well known antimicrobial agent and has recently started to be used in nanoparticulate form, with the advantage of a high specific surface area and a continuous release of enough...journal article 2008
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Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Duszczyk, J. (author)The invention relates to a method for applying a multifunctional layer on a substrate. Accordingly said layer is applied by means of a process by using an aqueous solution that comprises a POM and/or a crack-healing agent, which POM and/or a crack healing agent is/are incorporated in said layer during said process to obtain a self-healing layer.patent 2007