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Putra, N.E. (author), Tigrine, A. (author), Aksakal, S. (author), de la Rosa, V. R. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additively manufacturing of porous iron offers a unique opportunity to increase its biodegradation rate by taking advantage of arbitrarily complex porous structures. Nevertheless, achieving the required biodegradation profile remains challenging due to the natural passivation of iron that decrease the biodegradation rate. Moreover, the...journal article 2022
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Dong, J. (author), Tümer, N. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zadpoor, A.A. (author), Zhou, J. (author)Porous biodegradable Mg and its alloys are considered to have a great potential to serve as ideal bone substitutes. The recent progress in additive manufacturing (AM) has prompted its application to fabricate Mg scaffolds with geometrically ordered porous structures. Extrusion-based AM, followed by debinding and sintering, has been recently...journal article 2022
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Ganjian, M. (author), Modaresifar, K. (author), Rompolas, Dionysios (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Developing high-throughput nanopatterning techniques that also allow for precise control over the dimensions of the fabricated features is essential for the study of cell-nanopattern interactions. Here, we developed a process that fulfills both of these criteria. Firstly, we used electron-beam lithography (EBL) to fabricate precisely...journal article 2022
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van Manen, T. (author), Ganjian, M. (author), Modaresifar, K. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Folding nanopatterned flat sheets into complex 3D structures enables the fabrication of meta-biomaterials that combine a rationally designed 3D architecture with nanoscale surface features. Self-folding is an attractive approach for realizing such materials. However, self-folded lattices are generally too compliant as there is an inherent...journal article 2022
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Nouri Goushki, M. (author), Eijkel, B.I.M. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Modulation of the immune response following the implantation of biomaterials can have beneficial effects on bone regeneration. This involves complex interactions between the inflammatory and osteogenic cells. Therefore, the study of cell-cell interactions using direct co-culture models integrated with biomaterials is of great interest. This...journal article 2022
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Putra, N.E. (author), Leeflang, M.A. (author), Minneboo, M.B. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)Extrusion-based 3D printing followed by debinding and sintering is a powerful approach that allows for the fabrication of porous scaffolds from materials (or material combinations) that are otherwise very challenging to process using other additive manufacturing techniques. Iron is one of the materials that have been recently shown to be...journal article 2021
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Fazel, M. (author), Salimijazi, Hamid R. (author), Shamanian, Morteza (author), Minneboo, M.B. (author), Modaresifar, K. (author), van Hengel, I.A.J. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)The recently developed additively manufacturing techniques have enabled the fabrication of porous biomaterials that mimic the characteristics of the native bone, thereby avoiding stress shielding and facilitating bony ingrowth. However, aseptic loosening and bacterial infection, as the leading causes of implant failure, need to be further...journal article 2021
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Angeloni, L. (author), Ganjian, M. (author), Nouri Goushki, M. (author), Mirzaali, Mohammad J. (author), Hagen, C.W. (author), Zadpoor, A.A. (author), Fratila-Apachitei, E.L. (author), Ghatkesar, M.K. (author)Micro- and nano-patterns are gaining increasing attraction in several fields ranging from nanoelectronics to bioengineering. The mechanical properties of the nanostructures (nanopillars, nanotubes, nanowires, etc.) are highly relevant for many applications but challenging to determine. Existing mechanical characterization methods require...journal article 2021
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Dong, J. (author), Tümer, N. (author), Putra, N.E. (author), Zhu, Jia-Ning (author), Li, Y. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zadpoor, A.A. (author), Zhou, J. (author)Additively manufactured (AM) biodegradable magnesium (Mg) scaffolds with precisely controlled and fully interconnected porous structures offer unprecedented potential as temporary bone substitutes and for bone regeneration in critical-sized bone defects. However, current attempts to apply AM techniques, mainly powder bed fusion AM, for the...journal article 2021
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Putra, N.E. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additively manufactured biodegradable porous iron has been only very recently demonstrated. Two major limitations of such a biomaterial are very low biodegradability and incompatibility with magnetic resonance imaging (MRI). Here, we present a novel biomaterial that resolves both of those limitations. We used extrusion-based 3D printing to...journal article 2021
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Dimaraki, A. (author), Diaz Payno, P.J. (author), Minneboo, M.B. (author), Nouri Goushki, M. (author), Hosseini, M. (author), Kops, N. (author), Narcisi, R. (author), Mirzaali, Mohammad J. (author), van Osch, G.J.V.M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The treatment of articular cartilage defects remains a significant clinical challenge. This is partially due to current tissue engineering strategies failing to recapitulate native organization. Articular cartilage is a graded tissue with three layers exhibiting different cell densities: the superficial zone having the highest density and the...journal article 2021
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Nouri Goushki, M. (author), Isaakidou, A. (author), Eijkel, B.I.M. (author), Minneboo, M.B. (author), Liu, Q. (author), Boukany, P. (author), Mirzaali, Mohammad J. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The surface topography of engineered extracellular matrices is one of the most important physical cues regulating the phenotypic polarization of macrophages. However, not much is known about the ways through which submicron (i.e., 100-1000 nm) topographies modulate the polarization of macrophages. In the context of bone tissue regeneration,...journal article 2021
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Modaresifar, K. (author), Ganjian, M. (author), Angeloni, L. (author), Minneboo, M.B. (author), Ghatkesar, M.K. (author), Hagedoorn, P.L. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Despite the potential of small-scale pillars of black titanium (bTi) for killing the bacteria and directing the fate of stem cells, not much is known about the effects of the pillars’ design parameters on their biological properties. Here, three distinct bTi surfaces are designed and fabricated through dry etching of the titanium, each...journal article 2021
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Salandova, M. (author), van Hengel, I.A.J. (author), Apachitei, I. (author), Zadpoor, A.A. (author), van der Eerden, B.C.J. (author), Fratila-Apachitei, E.L. (author)Aseptic loosening of a permanent prosthesis remains one of the most common reasons for bone implant failure. To improve the fixation between implant and bone tissue as well as enhance blood vessel formation, bioactive agents are incorporated into the surface of the biomaterial. This study reviews and compares five bioactive elements (copper,...review 2021
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van Hengel, I.A.J. (author), Tierolf, M.W.A.M. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Patients receiving orthopedic implants are at risk of implant-associated infections (IAI). A growing number of antibiotic-resistant bacteria threaten to hamper the treatment of IAI. The focus has, therefore, shifted towards the development of implants with intrinsic antibacterial activity to prevent the occurrence of infection. The use of Ag, Cu...review 2021
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van Hengel, I.A.J. (author), Lacin, M. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Surface biofunctionalization is frequently applied to enhance the functionality and longevity of orthopedic implants. Here, we investigated the osteogenic effects of additively manufactured porous Ti6Al4V implants whose surfaces were biofunctionalized using plasma electrolytic oxidation (PEO) in Ca/P-based electrolytes with or without...journal article 2021
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Nouri Goushki, M. (author), Angeloni, L. (author), Modaresifar, K. (author), Minneboo, M.B. (author), Boukany, P. (author), Mirzaali, Mohammad J. (author), Ghatkesar, M.K. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The surface topography of implantable devices is of crucial importance for guiding the cascade of events that starts from the initial contact of the cells with the surface and continues until the complete integration of the device in its immediate environment. There is, however, limited quantitative information available regarding the...journal article 2021
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Honig, Floris (author), Vermeulen, Steven (author), Zadpoor, A.A. (author), de Boer, Jan (author), Fratila-Apachitei, E.L. (author)The ability to control the interactions between functional biomaterials and biological systems is of great importance for tissue engineering and regenerative medicine. However, the underlying mechanisms defining the interplay between biomaterial properties and the human body are complex. Therefore, a key challenge is to design biomaterials that...review 2020
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Modaresifar, K. (author), Kunkels, Lorenzo (author), Ganjian, M. (author), Tümer, N. (author), Hagen, C.W. (author), Otten, L.G. (author), Hagedoorn, P.L. (author), Angeloni, L. (author), Ghatkesar, M.K. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Recent progress in nano-/micro-fabrication techniques has paved the way for the emergence of synthetic bactericidal patterned surfaces that are capable of killing the bacteria via mechanical mechanisms. Different design parameters are known to affect the bactericidal activity of nanopatterns. Evaluating the effects of each parameter, isolated...journal article 2020
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Mechanics of bioinspired functionally graded soft-hard composites made by multi-material 3D printingMirzaali, Mohammad J. (author), Herranz de la Nava, A. (author), Gunashekar, D. (author), Nouri Goushki, M. (author), Veeger, R. P.E. (author), Grossman, Q. (author), Angeloni, L. (author), Ghatkesar, M.K. (author), Fratila-Apachitei, E.L. (author), Ruffoni, D. (author), Doubrovski, E.L. (author), Zadpoor, A.A. (author)Functional gradients are material transitions that are found in nature and are known to result in materials with superior properties and multiple functionalities. The emerging multi-material 3D printing (=additive manufacturing, AM) techniques provide a powerful tool for the design and fabrication of bioinspired functionally graded materials ...journal article 2020