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van Hengel, I.A.J. (author), Gelderman, F. S.A. (author), Athanasiadis, S. (author), Minneboo, M.B. (author), Weinans, Harrie (author), Fluit, A. C. (author), van der Eerden, B.C.J. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)The holy grail of orthopedic implant design is to ward off both aseptic and septic loosening for long enough that the implant outlives the patient. Questing this holy grail is feasible only if orthopedic biomaterials possess a long list of functionalities that enable them to discharge the onerous task of permanently replacing the native bone...journal article 2020
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De Witte, Tinke Marie (author), Wagner, Angela M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Peppas, Nicholas A. (author)To guide the natural bone regeneration process, bone tissue engineering strategies rely on the development of a scaffold architecture that mimics the extracellular matrix and incorporates important extracellular signaling molecules, which promote fracture healing and bone formation pathways. Incorporation of growth factors into particles...journal article 2020
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Razzi, F. (author), Fratila-Apachitei, E.L. (author), Fahy, N. (author), Bastiaansen-Jenniskens, Yvonne M. (author), Apachitei, I. (author), Farrell, E. (author), Zadpoor, A.A. (author)Additive manufacturing (AM) techniques have provided many opportunities for the rational design of porous metallic biomaterials with complex and precisely controlled topologies that give rise to unprecedented combinations of mechanical, physical, and biological properties. These favorable properties can be enhanced by surface...journal article 2020
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van Hengel, I.A.J. (author), Tierolf, M. W.A.M. (author), Valerio, V. P.M. (author), Minneboo, M.B. (author), Fluit, A. C. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Effective preventive measures against implant-associated infection (IAI) are desperately needed. Therefore, the development of self-defending implants with intrinsic antibacterial properties has gained significant momentum. Biomaterials biofunctionalized with silver (Ag) have resulted in effective antibacterial biomaterials, yet regularly...journal article 2020
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van Hengel, I.A.J. (author), Putra, N.E. (author), Tierolf, M. W.A.M. (author), Minneboo, M.B. (author), Fluit, A. C. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Antibiotic-resistant bacteria are frequently involved in implant-associated infections (IAIs), making the treatment of these infections even more challenging. Therefore, multifunctional implant surfaces that simultaneously possess antibacterial activity and induce osseointegration are highly desired in order to prevent IAIs. The incorporation...journal article 2020
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de Witte, Tinke Marie (author), Wagner, Angela M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Peppas, Nicholas A. (author)Bone tissue engineering strategies have been developed to address the limitations of the current gold standard treatment options for bone-related disorders. These systems consist of an engineered scaffold that mimics the extracellular matrix and provides an architecture to guide the natural bone regeneration process, and incorporated growth...journal article 2020
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Kramer, R.C.L.N. (author), Verlinden, E.J. (author), Angeloni, L. (author), Van Den Heuvel, Anita (author), Fratila-Apachitei, E.L. (author), Van Der Maarel, Silvère M. (author), Ghatkesar, M.K. (author)Microfluidic atomic force microscopy (AFM) cantilever probes have all the functionalities of a standard AFM cantilever along with fluid pipetting. They have a channel inside the cantilever and an aperture at the tip. Such probes are useful for precise fluid manipulation at a desired location, for example near or inside cells. They are...journal article 2020
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Callens, S.J.P. (author), Uyttendaele, Rafael J.C. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Recent evidence clearly shows that cells respond to various physical cues in their environments, guiding many cellular processes and tissue morphogenesis, pathology, and repair. One aspect that is gaining significant traction is the role of local geometry as an extracellular cue. Elucidating how geometry affects cell and tissue behavior is,...review 2020
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Nouri Goushki, M. (author), Mirzaali, Mohammad J. (author), Angeloni, L. (author), Fan, D. (author), Minneboo, M.B. (author), Ghatkesar, M.K. (author), Staufer, U. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Fabricating large areas of geometrically complex and precisely controlled topographies is required for the studies of cell behavior on patterned surfaces. Direct laser writing (DLW) is an advanced 3D-fabrication technique, which facilitates the manufacturing of structures within various scales (from a few hundred nanometers to millimeters)....journal article 2020
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Ganjian, M. (author), Angeloni, L. (author), Mirzaali, Mohammad J. (author), Modaresifar, K. (author), Hagen, C.W. (author), Ghatkesar, M.K. (author), Hagedoorn, P.L. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)One of the methods to create sub-10 nm resolution metal-composed 3D nanopillars is electron beam-induced deposition (EBID). Surface nanotopographies (e.g., nanopillars) could play an important role in the design and fabrication of implantable medical devices by preventing the infections that are caused by the bacterial colonization of the...journal article 2020
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Zhang, Yichuan (author), Venkateswaran, Seshasailam (author), Higuera, Gustavo A. (author), Nath, Suvra (author), Shpak, Guy (author), Matray, Jeffrey (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Kushner, Steven A. (author), Bradley, Mark (author), De Zeeuw, Chris I. (author)Substrates for neuron culture and implantation are required to be both biocompatible and display surface compositions that support cell attachment, growth, differentiation, and neural activity. Laminin, a naturally occurring extracellular matrix protein is the most widely used substrate for neuron culture and fulfills some of these...journal article 2020
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Modaresifar, K. (author), Azizian Amiri, S. (author), Ganjian, M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)We systematically reviewed the currently available evidence on how the design parameters of surface nanopatterns (e.g. height, diameter, and interspacing) relate to their bactericidal behavior. The systematic search of the literature resulted in 46 studies that satisfied the inclusion criteria of examining the bactericidal behavior of...review 2019
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Widyaratih, Dwisetya S. (author), Hagedoorn, P.L. (author), Otten, L.G. (author), Ganjian, M. (author), Tümer, N. (author), Apachitei, I. (author), Hagen, C.W. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Recent discoveries have shown that nanopatterns with feature sizes ≤100 nm could direct stem cell fate or kill bacteria. These effects could be used to develop orthopedic implants with improved osseointegration and decreased chance of implant-associated infections. The quest for osteogenic and bactericidal nanopatterns is ongoing but no...journal article 2019
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Sarkiri, Maria (author), Fox, Stephan C. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Clinical use of bioengineered skin in reconstructive surgery has been established for more than 30 years. The limitations and ethical considerations regarding the use of animal models have expanded the application of bioengineered skin in the areas of disease modeling and drug screening. These skin models should represent the anatomical and...review 2019
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Ganjian, M. (author), Modaresifar, K. (author), Ligeon, Manon R.O. (author), Kunkels, Lorenzo B. (author), Tümer, N. (author), Angeloni, L. (author), Hagen, C.W. (author), Otten, L.G. (author), Hagedoorn, P.L. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Development of synthetic bactericidal surfaces is a drug-free route to the prevention of implant-associated infections. Surface nanotopographies with specific dimensions have been shown to kill various types of bacterial strains through a mechanical mechanism, while regulating stem cell differentiation and tissue regeneration. The effective...journal article 2019
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Ganjian, M. (author), Modaresifar, K. (author), Zhang, H. (author), Hagedoorn, P.L. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)One of the major problems with the bone implant surfaces after surgery is the competition of host and bacterial cells to adhere to the implant surfaces. To keep the implants safe against implant-associated infections, the implant surface may be decorated with bactericidal nanostructures. Therefore, fabrication of nanostructures on...journal article 2019
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Nouri Goushki, M. (author), Sharma, Abhishek (author), Sasso, L. (author), Zhang, Shuang (author), van der Eerden, B.C.J. (author), Staufer, U. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Manufacturing high throughput in vitro models resembling the tissue microenvironment is highly demanded for studying bone regeneration. Tissues such as bone have complex multiscale architectures inside which cells reside. To this end, engineering a microfluidic platform incorporated with three-dimensional (3D) microscaffolds and submicron...journal article 2019
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De Witte, Tinke (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Peppas, Nicholas (author)In recent years, bone tissue engineering has emerged as a promising solution to the limitations of current gold standard treatment options for bone related-disorders such as bone grafts. Bone tissue engineering provides a scaffold design that mimics the extracellular matrix, providing an architecture that guides the natural bone regeneration...journal article 2018
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Hammann, C.P.W. (author), Heerkens, C.T.H. (author), Hagen, C.W. (author), Zadpoor, A.A. (author), Fratila-Apachitei, E.L. (author)Recent research evidences the strong modulatory role of controlled submicron and nanoscale topographies on stem cells fate. To harness these physical surface cues for clinical applications, fabrication of nano- and submicron patterns on clinically relevant biomaterials is greatly needed. In this study, an electron beam lithography method for...journal article 2018
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van Hengel, I.A.J. (author), Riool, Martijn (author), Fratila-Apachitei, E.L. (author), Witte-Bouma, Janneke (author), Farrell, Eric (author), Zadpoor, A.A. (author), Zaat, Sebastian A.J. (author), Apachitei, I. (author)Additively manufactured Ti-6Al-4V implants were biofunctionalized using plasma electrolytic oxidation. At various time points during this process scanning electron microscopy imaging was performed to analyze the surface morphology (van Hengel et al., 2017) [1]. This data shows the changes in surface morphology during plasma electrolytic...journal article 2017