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Effects of intima stiffness and plaque morphology on peak cap stress

Akyildiz, A.C. (author), Speelman, L. (author), Van Brummelen, H. (author), Gutiérrez, M.A. (author), Virmani, R. (author), Van der Lugt, A. (author), Van der Steen, A.F.W. (author), Wentzel, J.J. (author), Gijsen, F.J.H. (author)

Background: Rupture of the cap of a vulnerable plaque present in a coronary vessel may cause myocardial infarction and death. Cap rupture occurs when the peak cap stress exceeds the cap strength. The mechanical stress within a cap depends on the plaque morphology and the material characteristics of the plaque components. A parametric study was...

journal article 2011

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Atherosclerotic plaque fibrous cap assessment under an oblique scan plane orientation in carotid MRI

Nieuwstadt, H.A. (author), Van der Lugt, A. (author), Kassar, Z.A.M. (author), Breeuwer, M. (author), Van der Steen, A.F.W. (author), Gijsen, F.J.H. (author)

Carotid magnetic resonance imaging (MRI) is used to noninvasively assess atherosclerotic plaque fibrous cap (FC) status, which is closely related to ischemic stroke. Acquiring anisotropic voxels improves in-plane visualization, however, an oblique scan plane orientation could then obscure a FC (i.e., contrast below the noise level) and thus...

journal article 2014

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A computer-simulation study on the effects of MRI voxel dimensions on carotid plaque lipid-core and fibrous cap segmentation and stress modeling

Nieuwstadt, H.A. (author), Kassar, Z.A.M. (author), Van der Lugt, A. (author), Breeuwer, M. (author), Van der Steen, A.F.W. (author), Wentzel, J.J. (author), Gijsen, F.J.H. (author)

Background The benefits of a decreased slice thickness and/or in-plane voxel size in carotid MRI for atherosclerotic plaque component quantification accuracy and biomechanical peak cap stress analysis have not yet been investigated in detail because of practical limitations. Methods In order to provide a methodology that allows such an...

journal article 2015

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Influence of the accuracy of angiography-based reconstructions on velocity and wall shear stress computations in coronary bifurcations: A phantom study

Schrauwen, J.T.C. (author), Karanasos, A. (author), Van Ditzhuijzen, N.S. (author), Aben, J.P. (author), Van der Steen, A.F.W. (author), Wentzel, J.J. (author), Gijsen, F.J.H. (author)

Wall shear stress (WSS) plays a key role in the onset and progression of atherosclerosis in human coronary arteries. Especially sites with low and oscillating WSS near bifurcations have a higher propensity to develop atherosclerosis. WSS computations in coronary bifurcations can be performed in angiography-based 3D reconstructions. It is...

journal article 2015

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Peak cap stress calculations in coronary atherosclerotic plaques with an incomplete necrotic core geometry

Kok, Annette M. (author), Speelman, Lambert (author), Virmani, Renu (author), van der Steen, A.F.W. (author), Gijsen, F.J.H. (author), Wentzel, Jolanda J. (author)

Background: Stress calculations in atherosclerotic coronary vulnerable plaques can aid in predicting coronary cap rupture. In vivo plaque geometry and composition of coronary arteries can merely be obtained via intravascular imaging. Only optical driven imaging techniques have sufficient resolution to visualize the fibrous cap, but due to...

journal article 2016

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High Frame Rate Contrast-Enhanced Ultrasound for Velocimetry in the Human Abdominal Aorta

Voorneveld, J.D. (author), Engelhard, S. (author), Vos, H.J. (author), Reijnen, M. (author), Gijsen, F.J.H. (author), Versluis, M. (author), Jebbink, E. Groot (author), de Jong, N. (author), Bosch, J. G. (author)

Treatment of abdominal aortic (AA) aneurysms and stenotic lesions may be improved by analyzing their associated blood flow patterns. Angle-independent blood flow patterns in the AA can be obtained by combining echo-particle image velocimetry (ePIV) with high frame rate contrast-enhanced ultrasonography. However, ePIV performance is affected...

journal article 2018

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Tomographic PIV in a model of the left ventricle: 3D flow past biological and mechanical heart valves

Saaid, Hicham (author), Voorneveld, Jason (author), Schinkel, C.V. (author), Westenberg, Jos (author), Gijsen, F.J.H. (author), Segers, Patrick (author), Verdonck, Pascal (author), de Jong, N. (author), Kenjeres, S. (author)

Left ventricular flow is intrinsically complex, three-dimensional and unsteady. Its features are susceptible to cardiovascular pathology and treatment, in particular to surgical interventions involving the valves (mitral valve replacement). To improve our understanding of intraventricular fluid mechanics and the impact of various types of...

journal article 2019

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Imaging of inflammatory cellular protagonists in human atherosclerosis: a dual-isotope SPECT approach

Barrett, Hilary E. (author), Meester, Eric J. (author), van Gaalen, Kim (author), van der Heiden, Kim (author), Krenning, Boudewijn J. (author), Beekman, F.J. (author), Verhagen, H. J. (author), de Jong, M. (author), Gijsen, F.J.H. (author)

Purpose: Atherosclerotic plaque development and progression signifies a complex inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using single photon emission computed tomography (SPECT) coupled with computed tomography (CT), this study tested a new dual-isotope acquisition protocol to assess each radiotracer...

journal article 2020

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4-D Echo-Particle Image Velocimetry in a Left Ventricular Phantom

Voorneveld, J.D. (author), Saaid, H. (author), Schinkel, C.V. (author), Radeljic, Nikola (author), Lippe, Boris (author), Gijsen, F.J.H. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Claessens, Tom (author), Vos, H.J. (author), Kenjeres, S. (author), Bosch, Johan G. (author)

Left ventricular (LV) blood flow is an inherently complex time-varying 3-D phenomenon, where 2-D quantification often ignores the effect of out-of-plane motion. In this study, we describe high frame rate 4-D echocardiographic particle image velocimetry (echo-PIV) using a prototype matrix transesophageal transducer and a dynamic LV phantom for...

journal article 2020

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Morphometric and Mechanical Analyses of Calcifications and Fibrous Plaque Tissue in Carotid Arteries for Plaque Rupture Risk Assessment

Gijsen, F.J.H. (author), Vis, Bas (author), Barrett, Hilary E. (author), Zadpoor, A.A. (author), Verhagen, Hence J. (author), Bos, Daniel (author), van der Steen, A.F.W. (author), Akyildiz, A.C. (author)

Objective: Atherosclerotic plaque rupture in carotid arteries is a major source of cerebrovascular events. Calcifications are highly prevalent in carotid plaques, but their role in plaque rupture remains poorly understood. This work studied the morphometric features of calcifications in carotid plaques and their effect on the stress...

journal article 2021

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Identification of the haemodynamic environment permissive for plaque erosion

McElroy, Michael (author), Kim, Yongcheol (author), Niccoli, Giampaolo (author), Vergallo, Rocco (author), Langford-Smith, Alexander (author), Crea, Filippo (author), Gijsen, F.J.H. (author), Johnson, Thomas (author), Keshmiri, Amir (author)

Endothelial erosion of atherosclerotic plaques is the underlying cause of approximately 30% of acute coronary syndromes (ACS). As the vascular endothelium is profoundly affected by the haemodynamic environment to which it is exposed, we employed computational fluid dynamic (CFD) analysis of the luminal geometry from 17 patients with optical...

journal article 2021

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SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture

Van der Heiden, K. (author), Barrett, H. E. (author), van Gaalen, K.C. (author), Krenning, B. J. (author), Beekman, F.J. (author), Verhagen, H. J.M. (author), Norenberg, J. P. (author), de Jong, M. (author), Gijsen, F.J.H. (author)

Background: Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. The aim of this study was to evaluate their co-existing prevalence in human carotid plaques with respect to plaque phenotype to determine the value of hybrid imaging for the detection of these biomarkers....

journal article 2021

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Mechanical Characterization of Thrombi Retrieved with Endovascular Thrombectomy in Patients with Acute Ischemic Stroke

Boodt, Nikki (author), Snouckaert Van Schauburg, Philip R.W. (author), Hund, Hajo M. (author), Fereidoonnezhad, B.F. (author), McGarry, J. Patrick (author), Akyildiz, A.C. (author), Van Es, Adriaan C.G.M. (author), Van Der Lugt, Aad (author), Gijsen, F.J.H. (author)

Background and Purpose: Mechanical properties of thromboemboli play an important role in the efficacy of endovascular thrombectomy (EVT) for acute ischemic stroke. However, very limited data on mechanical properties of human stroke thrombi are available. We aimed to mechanically characterize thrombi retrieved with EVT, and to assess the...

journal article 2021

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Thrombus mechanics: How can we contribute to improve diagnostics and treatment?

Migliavacca, Francesco (author), Luraghi, G. (author), Akyildiz, A.C. (author), Gijsen, F.J.H. (author)

contribution to periodical 2022

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The Correlation Between Wall Shear Stress and Plaque Composition in Advanced Human Carotid Atherosclerosis

Moerman, A. M. (author), Korteland, S. (author), Dilba, K. (author), van Gaalen, K. (author), Poot, D. H.J. (author), van Der Lugt, A. (author), Verhagen, H. J.M. (author), Wentzel, J. J. (author), van Der Steen, A. F.W. (author), Gijsen, F.J.H. (author), Van der Heiden, K. (author)

The role of wall shear stress (WSS) in atherosclerotic plaque development is evident, but the relation between WSS and plaque composition in advanced atherosclerosis, potentially resulting in plaque destabilization, is a topic of discussion. Using our previously developed image registration pipeline, we investigated the relation between two...

journal article 2022

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Tissue-engineered collagenous fibrous cap models to systematically elucidate atherosclerotic plaque rupture

Wissing, T. B. (author), Van der Heiden, K. (author), Serra, S.M. (author), Smits, A. I.P.M. (author), Bouten, C. V.C. (author), Gijsen, F.J.H. (author)

A significant amount of vascular thrombotic events are associated with rupture of the fibrous cap that overlie atherosclerotic plaques. Cap rupture is however difficult to predict due to the heterogenous composition of the plaque, unknown material properties, and the stochastic nature of the event. Here, we aim to create tissue engineered...

journal article 2022

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Combined stent-retriever and aspiration intra-arterial thrombectomy performance for fragmentable blood clots: A proof-of-concept computational study

Luraghi, G. (author), Bridio, Sara (author), Lissoni, Vittorio (author), Dubini, Gabriele (author), Dwivedi, Anushree (author), McCarthy, Ray (author), Fereidoonnezhad, B.F. (author), McGarry, Patrick (author), Gijsen, F.J.H. (author)

Mechanical thrombectomy (MT) treatment of acute ischemic stroke (AIS) patients typically involves use of stent retrievers or aspiration catheters alone or in combination. For in silico trials of AIS patients, it is crucial to incorporate the possibility of thrombus fragmentation during the intervention. This study focuses on two aspects of...

journal article 2022

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Multicomponent material property characterization of atherosclerotic human carotid arteries through a Bayesian Optimization based inverse finite element approach

Guvenir Torun, Su (author), Torun, Hakki M. (author), Hansen, Hendrik H.G. (author), de Korte, Chris L. (author), van der Steen, Antonius F.W. (author), Gijsen, F.J.H. (author), Akyildiz, A.C. (author)

Objective: Plaque rupture in atherosclerotic carotid arteries is a main cause of ischemic stroke and it is correlated with high plaque stresses. Hence, analyzing stress patterns is essential for plaque specific rupture risk assessment. However, the critical information of the multicomponent material properties of atherosclerotic carotid...

journal article 2022

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A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Crielaard, Hanneke (author), Guvenir Torun, Su (author), Wissing, Tamar B. (author), de Miguel Muñoz, Pablo (author), Kremers, Gert Jan (author), Gijsen, F.J.H. (author), Van Der Heiden, Kim (author), Akyildiz, A.C. (author)

The rupture of atherosclerotic plaques in coronary and carotid arteries is the primary cause of fatal cardiovascular events. However, the rupture mechanics of the heterogeneous, highly collagenous plaque tissue, and how this is related to the tissue's fibrous structure, are not known yet. Existing pipelines to study plaque mechanics are...

journal article 2022

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The association between human blood clot analogue computed tomography imaging, composition, contraction, and mechanical characteristics

Cruts, Janneke M. H. (author), Giezen, Jo-Anne (author), van Gaalen, Kim (author), Beurskens, Robert (author), Ridwan, Yanto (author), Dijkshoorn, Marcel L. (author), Boodt, Nikki (author), Gijsen, F.J.H. (author), Cahalane, R.M.E. (author)

Background<br/>Clot composition, contraction, and mechanical properties are likely determinants of endovascular thrombectomy success. A pre-interventional estimation of these properties is hypothesized to aid in selecting the most suitable treatment for different types of thrombi. Here we determined the association between the aforementioned...

journal article 2023