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Kros, L. (author), Eelkman Rooda, O.H.J. (author), Spanke, J.K. (author), Alva, P. (author), Van Dongen, M.N. (author), Karapatis, A. (author), Tolner, E.A. (author), Strydis, C. (author), Davey, N. (author), Winkelman, B.H.J. (author), Negrello, M. (author), Serdijn, W.A. (author), Steuber, V. (author), Van den Maagdenberg, A.M.J.M. (author), De Zeeuw, C.I. (author), Hoebeek, F.E. (author)Objective Disrupting thalamocortical activity patterns has proven to be a promising approach to stop generalized spike-and-wave discharges (GSWDs) characteristic of absence seizures. Here, we investigated to what extent modulation of neuronal firing in cerebellar nuclei (CN), which are anatomically in an advantageous position to disrupt cortical...journal article 2015
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Van Dongen, M.N. (author), Hoebeek, F.E. (author), Koekkoek, S.K.E. (author), De Zeeuw, C.I. (author), Serdijn, W.A. (author)This paper investigates the efficacy of high frequency switched-mode neural stimulation. Instead of using a constant stimulation amplitude, the stimulus is switched on and off repeatedly with a high frequency (up to 100 kHz) duty cycled signal. By means of tissue modeling that includes the dynamic properties of both the tissue material as well...journal article 2015