Machine learning-based somatic variant calling in cell-free DNA of metastatic breast cancer patients using large NGS panels

Next generation sequencing of cell-free DNA (cfDNA) is a promising method for treatment monitoring and therapy selection in metastatic breast cancer (MBC). However, distinguishing tumor-specific variants from sequencing artefacts and germline variation with low false discovery rate is challenging when using large targeted sequencing panels...

Port city symbiosis: introduction to the special issue

Port cities and their neighbouring areas, located at the confines between sea and land, are key hubs in the transportation of goods and people. Ports serve global transport needs, while they are embedded in local geographies, topographies, political, economic and historical settlements. People have always been attracted to human settlements...

Port cities as hubs of diversity and inclusivity: The case of Rotterdam

Port cities are a particular type of territory and are often long-standing examples of resilience, bringing opportunities, wealth, and innovation to their nations and their citizens. They have developed at the crossroads of international trade and commerce and the intersection of sea and land. Flows of people through trade and migration have...