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Kenkhuis, Boyd (author), Somarakis, Antonios (author), Kleindouwel, Lynn R.T. (author), van Roon-Mom, Willeke M.C. (author), Höllt, T. (author), van der Weerd, Louise (author)Microglia have been identified as key players in Alzheimer's disease pathogenesis, and other neurodegenerative diseases. Iba1, and more specifically TMEM119 and P2RY12 are gaining ground as presumedly more specific microglia markers, but comprehensive characterization of the expression of these three markers individually as well as combined...journal article 2022
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Somarakis, Antonios (author), Ijsselsteijn, Marieke E. (author), Luk, Sietse J. (author), Kenkhuis, Boyd (author), de Miranda, Noel F. C. C. (author), Lelieveldt, B.P.F. (author), Höllt, T. (author)Spatially-resolved omics-data enable researchers to precisely distinguish cell types in tissue and explore their spatial interactions, enabling deep understanding of tissue functionality. To understand what causes or deteriorates a disease and identify related biomarkers, clinical researchers regularly perform large-scale cohort studies,...journal article 2021
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Kenkhuis, Boyd (author), Somarakis, Antonios (author), de Haan, Lorraine (author), Dzyubachyk, Oleh (author), Ijsselsteijn, Marieke E. (author), de Miranda, Noel F. C. C. (author), Lelieveldt, B.P.F. (author), Dijkstra, Jouke (author), Van Roon-Mom, Willeke (author), Höllt, T. (author), van der Weerd, Louise (author)Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ) positive Alzheimer patients, though the mechanism is still unknown. Microglia have been identified as key players in the disease pathogenesis, and are highly reactive cells responding to aberrations such as increased iron levels. Therefore, using...journal article 2021