A computational framework for pharmaco-mechanical interactions in arterial walls using parallel monolithic domain decomposition methods

A computational framework is presented to numerically simulate the effects of antihypertensive drugs, in particular calcium channel blockers, on the mechanical response of arterial walls. A stretch-dependent smooth muscle model by Uhlmann and Balzani is modified to describe the interaction of pharmacological drugs and the inhibition of smooth...

Surrogate convolutional neural network models for steady computational fluid dynamics simulations

A convolution neural network (CNN)-based approach for the construction of reduced order surrogate models for computational fluid dynamics (CFD) simulations is introduced; it is inspired by the approach of Guo, Li, and Iori [X. Guo, W. Li, and F. Iorio, Convolutional neural networks for steady flow approximation, in Proceedings of the 22nd ACM...

Adaptive Nonlinear Domain Decomposition Methods with an Application to the p-Laplacian

In this article, different nonlinear domain decomposition methods are applied to nonlinear problems with highly heterogeneous coefficient functions with jumps. In order to obtain a robust solver with respect to nonlinear as well as linear convergence, adaptive coarse spaces are employed. First, as an example for a nonlinearly left...

Adaptive GDSW Coarse Spaces of Reduced Dimension for Overlapping Schwarz Methods

A new reduced-dimension adaptive generalized Dryja-Smith-Widlund (GDSW) overlapping Schwarz method for linear second-order elliptic problems in three dimensions is introduced. It is robust with respect to large contrasts of the coefficients of the partial differential equations. The condition number bound of the new method is shown to be...