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Vente, M.A.D. (author), Nijsen, J.F.W. (author), De Wit, T.C. (author), Seppenwoolde, J.H. (author), Krijger, G.C. (author), Seevinck, P.R. (author), Huisman, A. (author), Zonneneberg, B.A. (author), Van den Ingh, T.S.G.A.M. (author), Van het Schip, A.D. (author)Purpose The aim of this study is to evaluate the toxicity of holmium-166 poly(l-lactic acid) microspheres administered into the hepatic artery in pigs. Methods Healthy pigs (20–30 kg) were injected into the hepatic artery with holmium-165-loaded microspheres (165HoMS; n?=?5) or with holmium-166-loaded microspheres (166HoMS; n?=?13). The...journal article 2008
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Zielhuis, S.W. (author), Seppenwoolde, J.H. (author), Mateus, V.A.P. (author), Bakker, C.J.G. (author), Krijger, G.C. (author), Storm, G. (author), Zonnenberg, B.A. (author), Van het Schip, A.D. (author), Koning, G.A. (author), Nijsen, J.F.W. (author)Many advanced molecular imaging agents are currently being investigated preclinically. Especially, liposomes, have proven to be very promising carrier systems for diagnostic agents for use in single-photon emission computed tomography (SPECT) or magnetic resonance imaging (MRI), as well as for therapeutic agents to treat diseases such as cancer....journal article 2006