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Biomarkers to discriminate between aseptic loosened and stable total hip or knee arthroplasties: a systematic review

Hasan, Shaho (author), van Schie, Peter (author), Kaptein, B.L. (author), Schoones, Jan W. (author), Marang-van de Mheen, P.J. (author), Nelissen, R.G.H.H. (author)

<b>Background</b>: Loosening is a major cause for failure of total hip and total knee arthroplasties (THAs/TKAs). Preemptive diagnostics of asymptomatic loosening could open strategies to prevent gross loosening. A multitude of biomarkers may discriminate between loosened and stable implants, but it is unknown which have the best performance....

review 2024

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Influence of marker-selection method in radiostereometric analysis of total knee arthroplasty on tibial baseplate migration patterns: a secondary analysis of a randomized controlled trial with 5-year follow-up

van der Lelij, T.J.N. (author), Koster, Lennard A. (author), Marang-van de Mheen, P.J. (author), Toksvig-Larsen, Sören (author), Nelissen, R.G.H.H. (author), Kaptein, B.L. (author)

Background and purpose — Different marker-selection methods are applied to represent implant and tibial seg-ments in radiostereometric analysis (RSA) studies of total knee arthroplasty (TKA). Either a consistent set of markers throughout subsequent RSA examinations (“consistent-marker method”) is used or all available markers at each follow...

journal article 2024

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Letter to the Editor: Failure of Screw/Shell Interface in Trident II Acetabular System in Total Hip Arthroplasty

van der Lelij, T.J.N. (author), Marang-van de Mheen, P.J. (author), Kaptein, B.L. (author), Nelissen, R.G.H.H. (author)

journal article 2024

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Introduction of innovations in joint arthroplasty: Recommendations from the ‘EFORT implant and patient safety initiative’

Overgaard, Søren (author), Grupp, Thomas M. (author), Nelissen, R.G.H.H. (author), Cristofolini, Luca (author), Lübbeke, Anne (author), Jäger, Marcus (author), Fink, Matthias (author), Achakri, Hassan (author), Benazzo, Francesco (author), Günther, Klaus-Peter (author)

review 2023

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Clockwise torque results in higher reoperation rates in left-sided femur fractures

Oosterhoff, J.H.F. (author), Dijkstra, H.F. (author), Karhade, Aditya V. (author), Poolman, Rudolf W. (author), Schipper, Inger B. (author), Nelissen, R.G.H.H. (author), van Embden, Daphne (author), Jaarsma, Ruurd L. (author), Schwab, Joseph H. (author)

Purpose: Effects of clockwise torque rotation onto proximal femoral fracture fixation have been subject of ongoing debate: fixated right-sided trochanteric fractures seem more rotationally stable than left-sided fractures in the biomechanical setting, but this theoretical advantage has not been demonstrated in the clinical setting to date. The...

journal article 2023

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Continued Stabilization of a Cementless 3D-Printed Total Knee Arthroplasty: Five-Year Results of a Randomized Controlled Trial Using Radiostereometric Analysis

van der Lelij, T.J.N. (author), Marang-van de Mheen, P.J. (author), Kaptein, B.L. (author), Toksvig-Larsen, Sören (author), Nelissen, R.G.H.H. (author)

BACKGROUND: Three-dimensional (3D) printing of highly porous orthopaedic implants aims to promote better osseointegration, thus preventing aseptic loosening. However, short-term radiostereometric analysis (RSA) after total knee arthroplasty (TKA) has shown higher initial migration of cementless 3D-printed tibial components compared with their...

journal article 2023

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Improved clinical investigation and evaluation of high-risk medical devices: the rationale and objectives of CORE-MD (Coordinating Research and Evidence for Medical Devices)

Fraser, Alan (author), Nelissen, R.G.H.H. (author), Kjærsgaard-Andersen, P. (author), Szymański, P. (author), Melvin, T. (author), Piscoi, P. (author), Fraser, Alan (author), Szymański, Piotr (author), Gale, Chris (author), Maggioni, Aldo (author), Zanon, Elisabetta (author), Dimopoulou, Christina (author), Ceccarelli, Cinzia (author), Vairami, Polyxeni (author), Ruszanov, Anett (author), Kjærsgaard-Andersen, Per (author), Nelissen, Rob (author), Ott, Adrian (author), Macintyre, Elizabeth (author), Simulescu, Loredana (author), Meijer, Marieke (author), Koletzko, Berthold (author), Wieczorek, Sarah (author), Hadjipanayis, Adamos (author), Del Torso, Stefano (author), Marang-van de Mheen, P.J. (author), Hoogervorst, L. (author), Steyerberg, Ewout W. (author), de Vries, B. (author), McCulloch, Peter (author), Landray, Martin (author), Alhambra, Daniel Prieto (author), Smith, James (author), Lubbeke-Wolf, Anne (author), James, Stefan (author), Buccheri, Sergio (author), Byrne, Robert (author), McGovern, Laurna (author), Windecker, Stephan (author), Frenk, Andre (author), Siontis, Georgios (author), Stettler, Christoph (author), Bano, Arjola (author), Bally, Lia (author), Rademakers, Frank E. (author), D'hooge, Jan (author), Vedder, Anton (author), Biasin, Elisabetta (author), Kamenjasevic, Erik (author), Schnell-Inderst, Petra (author)

In the European Union (EU) the delivery of health services is a national responsibility but there are concerted actions between member states to protect public health. Approval of pharmaceutical products is the responsibility of the European Medicines Agency, whereas authorizing the placing on the market of medical devices is decentralized to...

journal article 2022

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Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration

Coutinho de Almeida, Rodrigo (author), Mahfouz, A.M.E.T.A. (author), Mei, Hailiang (author), Houtman, Evelyn (author), den Hollander, Wouter (author), Soul, Jamie (author), Suchiman, Eka (author), Nelissen, R.G.H.H. (author), Reinders, M.J.T. (author)

OBJECTIVE: To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or clinically relevant characteristics. METHODS: This study includes n = 66 primary OA patients (41 knees and 25 hips), who underwent a joint replacement surgery, from which...

journal article 2021

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Migration behaviour of 2 clinically excellent cementless stems with different design rationales: 5-year follow-up of a randomised RSA-study

van der Voort, Paul (author), van Delft, Danny (author), Valstar, E.R. (author), Kaptein, B.L. (author), Fiocco, Marta (author), Nelissen, R.G.H.H. (author)

Introduction: Excellent long-term survival has been reported for both the Taperloc and the Mallory-Head cementless stems. However, little is known about the migration behaviour of these stems which have different design rationales. The purpose of this randomised clinical trial was to compare the migration and clinical outcomes of these stems...

journal article 2021

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Long-term migration of a cementless stem with different bioactive coatings. Data from a “prime” RSA study: lessons learned

Van Der Voort, Paul (author), D Klein Nulent, Martijn L. (author), Valstar, E.R. (author), Kaptein, B.L. (author), Fiocco, Marta (author), Nelissen, R.G.H.H. (author)

Background and purpose — Little is known about the long-term migration pattern of cementless stems in total hip arthroplasty (THA). Furthermore, the role of bioactive coatings in fixation, and thus migration, remains uncertain. Hydroxyapatite (HA) is the most commonly used bioactive coating. However, delamination of the coating might induce...

journal article 2020

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Water Jet Applicator for Interface Tissue Removal in Minimally Invasive Hip Refixation: Testing the Principle and Design of Prototype

Kraaij, G. (author), Loeve, A.J. (author), Dankelman, J. (author), Nelissen, R.G.H.H. (author), Valstar, E.R. (author)

Mechanical loosening of implants is in the majority accompanied with a periprosthetic interface membrane, which has to be removed during revision surgery. The same is true if a minimal invasive (percutaneous) refixation of a loose implant is done. We describe the requirements for a waterjet applicator for interface tissue removal for this...

journal article 2019

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A novel treatment for anterior shoulder instability: A biomechanical comparison between a patient-specific implant and the Latarjet procedure

Willemsen, K. (author), Berendes, Thomas D. (author), Geurkink, Timon (author), Bleys, Ronald L.A.W. (author), Leeflang, M.A. (author), Weinans, Harrie (author), Castelein, René M. (author), Nelissen, R.G.H.H. (author), van der Wal, Bart C.H. (author)

BACKGROUND: Anterior glenohumeral instability with &gt;20% glenoid bone loss is a disorder that can be treated with the Latarjet stabilizing procedure; however, complications are common. The purposes of this study were to (1) evaluate the effect of an anatomic-specific titanium implant produced by 3-dimensional (3D) printing as a treatment...

journal article 2019

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RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage

Coutinho de Almeida, Rodrigo (author), Ramos, Yolande F.M. (author), Mahfouz, A.M.E.T.A. (author), den Hollander, Wouter (author), Lakenberg, Nico (author), Houtman, Evelyn (author), van Hoolwerff, Marcella (author), Suchiman, H. Eka D. (author), Rodriguez-Ruiz, Alejandro (author), Slagboom, P. Eline (author), Mei, Hailiang (author), Kielbasa, Szymon M. (author), Nelissen, R.G.H.H. (author), Reinders, M.J.T. (author), Meulenbelt, Ingrid (author)

Objective To uncover the microRNA (miRNA) interactome of the osteoarthritis (OA) pathophysiological process in the cartilage.<br/>Methods We performed RNA sequencing in 130 samples (n=35 and n=30 pairs for messenger RNA (mRNA) and miRNA, respectively) on macroscopically preserved and lesioned OA cartilage from the same patient and performed...

journal article 2018

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Migration and clinical outcome of mobile-bearing versus fixed-bearing single-radius total knee arthroplasty: A randomized controlled trial

Van Hamersveld, Koen T. (author), Marang-van de Mheen, P.J. (author), Van Der Heide, Huub J.L. (author), Van Der Linden-Van Der Zwaag, Henrica M.J. (author), Valstar, E.R. (author), Nelissen, R.G.H.H. (author)

Background and purpose — Mobile-bearing total knee prostheses (TKPs) were developed in the 1970s in an attempt to increase function and improve implant longevity. However, modern fixed-bearing designs like the single-radius TKP may provide similar advantages. We compared tibial component migration measured with radiostereometric analysis (RSA)...

journal article 2018

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Edward Valstar (1970–2017): In memoriam

Nelissen, R.G.H.H. (author), Kaptein, B.L. (author), Veeger, H.E.J. (author)

journal article 2017

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Peri-prosthetic tissue cells show osteogenic capacity to differentiate into the osteoblastic lineage

Schoeman, Monique A.E. (author), Oostlander, Angela E. (author), Rooij, Karien Ede (author), Valstar, E.R. (author), Nelissen, R.G.H.H. (author)

During the process of aseptic loosening of prostheses, particulate wear debris induces a continuous inflammatory-like response resulting in the formation of a layer of fibrous peri-prosthetic tissue at the bone-prosthesis interface. The current treatment for loosening is revision surgery which is associated with a high-morbidity rate,...

journal article 2017

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Palacos compared to Palamed bone cement in total hip replacement: a randomized controlled trial: RSA migration similar at 10-year follow-up

Meinardi, J.E. (author), Valstar, E.R. (author), van der Voort, P (author), Kaptein, B.L. (author), Fiocco, M. (author), Nelissen, R.G.H.H. (author)

Background and purpose — Stability and survival of cemented total hip prostheses is dependent on a multitude of factors, including the type of cement that is used. Bone cements vary in viscosity, from low to medium and high. There have been few clinical RSA studies comparing the performance of low- and high-viscosity bone cements. We compared...

journal article 2016

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Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

Bomer, N. (author), Den Hollander, W.T.H.F. (author), Ramos, Y.F.M. (author), Bos, S.D. (author), Van der Breggen, R. (author), Lakenberg, N. (author), Pepers, B.A. (author), Van Eeden, A.E. (author), Darvishan, A. (author), Tobi, E.W. (author), Duijnisveld, B.J. (author), Van den Akker, E.B. (author), Heijmans, B.T. (author), Van Roon-Mom, W.M.C. (author), Verbeek, F.J. (author), Osch, G.J.V.M. (author), Nelissen, R.G.H.H. (author), Slagboom, P.E. (author), Meulenbelt, I. (author)

Objectives: To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the deleterious effect could contribute to novel therapeutic approaches. Methods: Epigenetically regulated expression of DIO2 was explored by assessing methylation of positional CpG...

journal article 2015

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A fluoroscopy-based planning and guidance software tool for minimally invasive hip refixation by cement injection

Malan, D.F. (author), Van der Walt, S.J. (author), Raidou, R.G. (author), Van den Berg, B. (author), Stoel, B.C. (author), Botha, C.P. (author), Nelissen, R.G.H.H. (author), Valstar, E.R. (author)

Purpose In orthopaedics, minimally invasive injection of bone cement is an established technique. We present HipRFX, a software tool for planning and guiding a cement injection procedure for stabilizing a loosening hip prosthesis. HipRFX works by analysing a pre-operative CT and intraoperative C-arm fluoroscopic images. Methods HipRFX simulates...

journal article 2015

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Early subsidence of shape-closed hip arthroplasty stems is associated with late revision

Van der Voort, P. (author), Pijls, B.G. (author), Nieuwenhuijse, M.J. (author), Jasper, J. (author), Fiocco, M. (author), Plevier, J.W.M. (author), Middeldorp, S. (author), Valstar, E.R. (author), Nelissen, R.G.H.H. (author)

Background and purpose — Few studies have addressed the association between early migration of femoral stems and late aseptic revision in total hip arthroplasty. We performed a meta-regression analysis on 2 parallel systematic reviews and meta-analyses to determine the association between early migration and late aseptic revision of femoral...

journal article 2015