Searched for: author:"Niessen, W.J."
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Knol, Maria J. (author), Heshmatollah, Alis (author), Cremers, Lotte G M (author), Ikram, Mohammad K. (author), Uitterlinden, André G. (author), van Duijn, Cornelia M. (author), Niessen, W.J. (author), Vernooij, Meike W. (author), Ikram, Mohammad Arfan (author), Adams, Hieab H.H. (author)
Cognition in adults shows variation due to developmental and degenerative components. A recent genome-wide association study identified genetic variants for general cognitive function in 148 independent loci. Here, we aimed to elucidate possible developmental and neurodegenerative pathways underlying these genetic variants by relating them to...
journal article 2019
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Dubost, Florian (author), Yilmaz, Pinar (author), Adams, Hieab H (author), Bortsova, Gerda (author), Ikram, Mohammad A. (author), Niessen, W.J. (author), Vernooij, Meike W. (author), de Bruijne, Marleen (author)
Enlarged perivascular spaces (PVS) are structural brain changes visible in MRI, are common in aging, and are considered a reflection of cerebral small vessel disease. As such, assessing the burden of PVS has promise as a brain imaging marker. Visual and manual scoring of PVS is a tedious and observer-dependent task. Automated methods would...
journal article 2019
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Vinke, Elisabeth J. (author), Huizinga, W. (author), Bergtholdt, Martin (author), Adams, Hieab H. (author), Steketee, Rebecca M E (author), Papma, Janne M. (author), De Jong, Frank Jan (author), Niessen, W.J. (author), Ikram, Mohammad Arfan (author), More Authors (author)
Brain imaging data are increasingly made publicly accessible, and volumetric imaging measures derived from population-based cohorts may serve as normative data for individual patient diagnostic assessment. Yet, these normative cohorts are usually not a perfect reflection of a patient's base population, nor are imaging parameters such as field...
journal article 2019
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Bouts, Mark J.R.J. (author), Van Der Grond, Jeroen (author), Vernooij, Meike W. (author), Koini, Marisa (author), Schouten, T.M. (author), de Vos, Frank (author), Feis, Rogier A. (author), Lechner, Anita (author), Niessen, W.J. (author), More Authors (author)
Early and accurate mild cognitive impairment (MCI) detection within a heterogeneous, nonclinical population is needed to improve care for persons at risk of developing dementia. Magnetic resonance imaging (MRI)-based classification may aid early diagnosis of MCI, but has only been applied within clinical cohorts. We aimed to determine the...
journal article 2019
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van der Lee, S.J. (author), Knol, Maria J. (author), Chauhan, Ganesh (author), Satizabal, Claudia L. (author), Smith, Albert Vernon (author), Hofer, Edith (author), Bis, Joshua C. (author), van den Akker, E.B. (author), Niessen, W.J. (author), More Authors (author)
Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific lobar volumes independent of intracranial...
journal article 2019
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Adams, Hieab H.H. (author), Roshchupkin, Gennady V. (author), Decarli, Charles (author), Franke, Barbara (author), Grabe, H. J. (author), Habes, Mohamad (author), Jahanshad, Neda (author), Medland, Sarah E. (author), Niessen, W.J. (author), More Authors (author)
Advances in technology enable increasing amounts of data collection from individuals for biomedical research. Such technologies, for example, in genetics and medical imaging, have also led to important scientific discoveries about health and disease. The combination of multiple types of high-throughput data for complex analyses, however, has...
journal article 2019
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Meeter, Lieke H.H. (author), Steketee, Rebecca M E (author), Salkovic, Dina (author), Vos, Maartje E. (author), Grossman, Murray (author), McMillan, Corey T. (author), Niessen, W.J. (author), Papma, Janne M. (author), De Jong, Frank Jan (author), More Authors (author)
Background: Semantic dementia (SD) is a neurodegenerative disorder characterised by progressive language problems falling within the clinicopathological spectrum of frontotemporal lobar degeneration (FTLD). The development of disease-modifying agents may be facilitated by the relative clinical and pathological homogeneity of SD, but we need...
journal article 2019
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Zonneveld, Hazel I. (author), Pruim, R.H.R. (author), Bos, Daniel (author), Vrooman, Henri A. (author), Muetzel, Ryan L. (author), Hofman, Albert (author), Rombouts, Serge ARB (author), Niessen, W.J. (author), More Authors (author)
Structural brain markers are studied extensively in the field of neurodegeneration, but are thought to occur rather late in the process. Functional measures such as functional connectivity are gaining interest as potentially more subtle markers of neurodegeneration. However, brain structure and function are also affected by ‘normal’ brain...
journal article 2019
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Venkatraghavan, Vikram (author), Bron, Esther E. (author), Niessen, W.J. (author), Klein, S. (author)
Alzheimer's Disease (AD) is characterized by a cascade of biomarkers becoming abnormal, the pathophysiology of which is very complex and largely unknown. Event-based modeling (EBM) is a data-driven technique to estimate the sequence in which biomarkers for a disease become abnormal based on cross-sectional data. It can help in understanding...
journal article 2019
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Achterberg, Hakim C. (author), Sørensen, Lauge (author), Wolters, Frank J, (author), Niessen, W.J. (author), Vernooij, Meike W. (author), Ikram, Mohammad Arfan (author), Nielsen, Mads (author), de Bruijne, Marleen (author)
Hippocampal volume and shape are known magnetic resonance imaging biomarkers of neurodegeneration. Recently, hippocampal texture has been shown to improve prediction of dementia in patients with mild cognitive impairment, but it is unknown whether texture adds prognostic information beyond volume and shape and whether the predictive value...
journal article 2019
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Vinke, Elisabeth J. (author), De Groot, Marius (author), Venkatraghavan, Vikram (author), Klein, S. (author), Niessen, W.J. (author), Ikram, Mohammad A. (author), Vernooij, Meike W. (author)
With aging, the brain undergoes several structural changes. These changes reflect the normal aging process and are therefore not necessarily pathologic. In fact, better understanding of these normal changes is an important cornerstone to also disentangle pathologic changes. Several studies have investigated normal brain aging, both cross...
journal article 2018
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de Jong, M.A. (author), Hysi, Pirro (author), Spector, Tim (author), Niessen, W.J. (author), Koudstaal, M.J. (author), Wolvius, Eppo B. (author), Kayser, Manfred (author), Böhringer, Stefan (author)
Landmarking of 3D facial surface scans is an important analysis step in medical and biological applications, such as genome-wide association studies (GWAS). Manual landmarking is often employed with considerable cost and rater dependent variability. Landmarking automatically with minimal training is therefore desirable. We apply statistical...
journal article 2018
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Tap, Lisanne (author), van Opbroek, A (author), Niessen, W.J. (author), Smits, Marion (author), Mattace-Raso, Francesco U. S. (author)
journal article 2018
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Guyader, Jean Marie (author), Huizinga, W. (author), Poot, D.H.J. (author), Kranenburg, Matthijs Van (author), Uitterdijk, André (author), Niessen, W.J. (author), Klein, S. (author)
The most widespread technique used to register sets of medical images consists of selecting one image as fixed reference, to which all remaining images are successively registered. This pairwise scheme requires one optimization procedure per pair of images to register. Pairwise mutual information is a common dissimilarity measure applied to a...
journal article 2018
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Langen, Carolyn D (author), Muetzel, Ryan L. (author), Blanken, Laura M E (author), Tiemeier, Henning (author), Verhulst, F.A.H. (author), Niessen, W.J. (author), White, Tonya (author)
Introduction: Typical brain development is characterized by specific patterns of maturation of functional networks. Cortico-cortical connectivity generally increases, whereas subcortico-cortical connections often decrease. Little is known about connectivity changes amongst different subcortical regions in typical development. Methods: This...
journal article 2018
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Starmans, Martijn P.A. (author), Miclea, Razvan L. (author), Niessen, W.J. (author), Thomeer, Maarten G. (author), Klein, S. (author)
Correct diagnosis of the liver tumor phenotype is crucial for treatment planning, especially the distinction between malignant and benign lesions. Clinical practice includes manual scoring of the tumors on Magnetic Resonance (MR) images by a radiologist. As this is challenging and subjective, it is often followed by a biopsy. In this study,...
conference paper 2018
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Santos, Emilie M M (author), D’Esterre, C. D. (author), Treurniet, Kilian M. (author), Niessen, W.J. (author), Abou Najm, M (author), Goyal, M. (author), Demchuk, A. M. (author), Majoie, C. B L M (author), Menon, B. K. (author), Marquering, Henk A. (author)
Purpose: Thrombus perviousness has been associated with favorable functional outcome in acute ischemic stroke (AIS) patients. Measuring thrombus perviousness on CTA may be suboptimal due to potential delay in contrast agent arrival in occluded arteries at the moment of imaging. Dynamic sequences acquired over time can potentially overcome...
journal article 2018
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White, J.T. (author), Niessen, W.J. (author), Reiss, Irwin K.M. (author), Tibboel, D. (author), Hoebeek, Freek E. (author), Dudink, J (author)
BACKGROUND AND PURPOSE: Infants born preterm are commonly diagnosed with structural brain lesions known to affect long-term neurodevelopment negatively. Yet, the effects of preterm birth on brain development in the absence of intracranial lesions remain to be studied in detail. In this study, we aim to quantify long term consequences of...
journal article 2018
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Chaker, Layal (author), Cremers, Lotte G M (author), Korevaar, Tim I.M. (author), De Groot, Marius (author), Dehghan, Abbas (author), Franco, Oscar H. (author), Niessen, W.J. (author), Ikram, Mohammad A. (author), Peeters, Robin P. (author), Vernooij, Meike W. (author)
Thyroid hormone (TH) is crucial during neurodevelopment, but high levels of TH have been linked to neurodegenerative disorders. No data on the association of thyroid function with brain imaging in the general population are available. We therefore investigated the association of thyroid-stimulating hormone and free thyroxine (FT4) with...
journal article 2018
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Vernooij, Meike W. (author), Jasperse, Bas (author), Steketee, Rebecca M E (author), Koek, M. (author), Vrooman, Henri A. (author), Ikram, Mohammad A. (author), Papma, Janne M. (author), Smits, Marion (author), Niessen, W.J. (author)
Objectives: To assesses whether automated brain image analysis with quantification of structural brain changes improves diagnostic accuracy in a memory clinic setting. Methods: In 42 memory clinic patients, we evaluated whether automated quantification of brain tissue volumes, hippocampal volume and white matter lesion volume improves...
journal article 2018
Searched for: author:"Niessen, W.J."
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