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- Klein, M. (author), Bera, Subhas C. (author), Anderson, Thomas K. (author), Wang, Bing (author), Papini, Flavia S. (author), Arnold, Jamie J. (author), Cameron, Craig E. (author), Depken, S.M. (author), Dulin, D. (author) journal article 2023
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Bera, Subhas Chandra (author), Seifert, Mona (author), Kirchdoerfer, Robert N. (author), van Nies, Pauline (author), Wubulikasimu, Yibulayin (author), Quack, Salina (author), Papini, Flávia S. (author), Depken, S.M. (author), Dulin, D. (author)Coronaviruses have evolved elaborate multisubunit machines to replicate and transcribe their genomes. Central to these machines are the RNA-dependent RNA polymerase subunit (nsp12) and its intimately associated cofactors (nsp7 and nsp8). We use a high-throughput magnetic-tweezers approach to develop a mechanochemical description of this core...journal article 2021
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Seifert, Mona (author), van Nies, Pauline (author), Papini, Flávia S. (author), Arnold, Jamie J. (author), Poranen, Minna M. (author), Cameron, Craig E. (author), Depken, S.M. (author), Dulin, D. (author)RNA virus survival depends on efficient viral genome replication, which is performed by the viral RNA dependent RNA polymerase (RdRp). The recent development of high throughput magnetic tweezers has enabled the simultaneous observation of dozens of viral RdRp elongation traces on kilobases long templates, and this has shown that RdRp...journal article 2020