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Plesa, C. (author), Verschueren, D.V. (author), Pud, S. (author), van der Torre, J. (author), Ruitenberg, J.W. (author), Witteveen, M.J. (author), Jonsson, P.M. (author), Grosberg, Alexander Y. (author), Rabin, Yitzhak (author), Dekker, C. (author)Long DNA molecules can self-entangle into knots. Experimental techniques for observing such DNA knots (primarily gel electrophoresis) are limited to bulk methods and circular molecules below 10 kilobase pairs in length. Here, we show that solid-state nanopores can be used to directly observe individual knots in both linear and circular single...journal article 2016
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Plesa, C. (author), Van Loo, N. (author), Dekker, C. (author)Nanopore experiments have traditionally been carried out with chloride-based solutions. Here we introduce silver/silver-glutamate-based electrochemistry as an alternative, and study the viscosity, conductivity, and nanopore translocation characteristics of potassium-, sodium-, and lithium-glutamate solutions. We show that it has a linear...journal article 2015
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Plesa, C. (author)Solid-state nanopores are small nanometer-scale holes in thin membranes. When used to separate two chambers containing salt solution, any biomolecule passing from one chamber to the other is forced to pass through the pore constriction. An electric field applied across the membrane is used to create an ionic current and electrophoretically drive...doctoral thesis 2015
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- De Vlaminck, I. (author), Plesa, C. (author), Dekker, C. (author) patent 2013