Metabolic trade-offs arising from increased free energy conservation in Saccharomyces cerevisiae

This thesis deals with increasing the free energy conservation in<br/>chemotropic microorganisms with emphasis on S. cerevisiae and investigates<br/>a number of different aspects related to industrial fermentation processes.

Effective Estimation of Dynamic Metabolic Fluxes Using 13C Labeling and Piecewise Affine Approximation: From Theory to Practical Applicability

The design of microbial production processes relies on rational choices for metabolic engineering of the production host and the process conditions. These require a systematic and quantitative understanding of cellular regulation. Therefore, a novel method for dynamic flux identification using quantitative metabolomics and 13C labeling to...

Human factors in thermal indoor climate and therma comfort