Biocompatible optical physically unclonable function hydrogel microparticles for on-dose authentication

On-dose authentication (ODA) enhances security by incorporating customized molecular or micro-tags into each pill, preventing counterfeit products in genuine packages. ODA's security relies on tag non-replication and non-reverse engineering. Combining ODA with graphical Physical Unclonable Functions (PUF) promises maximum security. PUF uses...

Identifying Aging and Alzheimer Disease–Associated Somatic Variations in Excitatory Neurons From the Human Frontal Cortex

Background and Objectives - With age, somatic mutations accumulated in human brain cells can lead to various neurologic disorders and brain tumors. Because the incidence rate of Alzheimer disease (AD) increases exponentially with age, investigating the association between AD and the accumulation of somatic mutation can help understand the...

The correlation between neuropathology levels and cognitive performance in centenarians

INTRODUCTION: Neuropathological substrates associated with neurodegeneration occur in brains of the oldest old. How does this affect cognitive performance?. METHODS: The 100-plus Study is an ongoing longitudinal cohort study of centenarians who self-report to be cognitively healthy; post mortem brain donation is optional. In 85 centenarian...

An Edible Humidity Indicator That Responds to Changes in Humidity Mechanically

Elevated humidity levels in medical, food, and pharmaceutical products may reduce the products' shelf life, trigger bacterial growth, and even lead to complete spoilage. In this study, we report a humidity indicator that mechanically bends and rolls itself irreversibly upon exposure to high humidity conditions. The indicator is made of two...

Microfluidic Synthesis of Hydrogel Microparticles with Superparamagnetic Colloids Embedded at Prescribed Positions for Anticounterfeiting Applications

A microfluidic platform for continuous synthesis of hydrogel microparticles with superparamagnetic colloids (SPCs) embedded at prescribed positions is described. The shape of the cross-linked microparticle is independently controlled by stop–flow lithography, whereas the position of trapped SPCs are dictated by virtual magnetic moulds made of...

Resilience and resistance to the accumulation of amyloid plaques and neurofibrillary tangles in centenarians: An age-continuous perspective

Introduction: With increasing age, neuropathological substrates associated with Alzheimer's disease (AD) accumulate in brains of cognitively healthy individuals—are they resilient, or resistant to AD-associated neuropathologies?. Methods: In 85 centenarian brains, we correlated NIA (amyloid) stages, Braak (neurofibrillary tangle) stages, and...

Effect of temperature and humidity on moisture diffusion in an epoxy moulding compound material

In this paper we propose a new multistep characterisation method to be able to map out the dependency of moisture diffusion parameters of a polymeric material over a range of temperature and humidity conditions in a limited amount of time. We do that by (1) using a moisture sorption analyser which can continuously monitor weight changes with...

Influence of moisture condition on chloride diffusion in partially saturated ordinary Portland cement mortar

Experiments have been carried out to study the influence of moisture condition, including moisture content and its distribution, on the chloride diffusion in partially saturated ordinary Portland cement mortar. The mortar samples with water-to-cement (w/c) ratios of 0.4, 0.5 and 0.6, cured for 1 year, were preconditioned to uniform water...

Modeling Spatial Contacts for Epidemic Prediction in a Large-Scale Artificial City

Spatial contacts among human beings are considered as one of the influential factors during the transmission of contagious diseases, such as influenza and tuberculosis. Therefore, representing and understanding spatial contacts plays an important role in epidemic modeling research. However, most current research only considers regular spatial...

CGILS: Results from the first phase of an international project to understand the physical mechanisms of low cloud feedbacks in single column models

CGILS—the CFMIP-GASS Intercomparison of Large Eddy Models (LESs) and single column models (SCMs)—investigates the mechanisms of cloud feedback in SCMs and LESs under idealized climate change perturbation. This paper describes the CGILS results from 15 SCMs and 8 LES models. Three cloud regimes over the subtropical oceans are studied: shallow...

Experimental Study on Cementitious Composites Embedded with Organic Microcapsules

The recovery behavior for strength and impermeability of cementitious composites embedded with organic microcapsules was investigated in this study. Mortar specimens were formed by mixing the organic microcapsules and a catalyst with cement and sand. The mechanical behaviors of flexural and compression strength were tested. The results showed...

Marine low cloud sensitivity to an idealized climate change: The CGILS LES intercomparison

Subtropical marine low cloud sensitivity to an idealized climate change is compared in six large-eddy simulation (LES) models as part of CGILS. July cloud cover is simulated at three locations over the subtropical northeast Pacific Ocean, which are typified by cold sea surface temperatures (SSTs) under well-mixed stratocumulus, cool SSTs under...