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van Dijk, Bruce (author), Oliveira, Sabrina (author), Hooning van Duyvenbode, J. Fred F. (author), Nurmohamed, F. Ruben H.A. (author), Mashayekhi, Vida (author), Beltran Hernandez, Irati (author), van Strijp, Jos (author), de Vor, Lisanne (author), Aerts, Piet C. (author), Vogely, H. Charles (author), Weinans, Harrie (author), van der Wal, Bart C.H. (author)Introduction Implant infections caused by Staphylococcus aureus are responsible for high mortality and morbidity worldwide. Treatment of these infections can be difficult especially when bacterial biofilms are involved. In this study we investigate the potential of infrared photoimmunotherapy to eradicate staphylococcal infection in a mouse...journal article 2024
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Cecotto, Leonardo (author), Stapels, Daphne A.C. (author), van Kessel, Kok P.M. (author), Croes, Michiel (author), Lourens, Zeldali (author), Vogely, H. Charles (author), van der Wal, Bart C.H. (author), van Strijp, Jos A.G. (author), Weinans, Harrie (author), Amin Yavari, Saber (author)Background: Despite the extensive use of silver ions or nanoparticles in research related to preventing implant-associated infections (IAI), their use in clinical practice has been debated. This is because the strong antibacterial properties of silver are counterbalanced by adverse effects on host cells. One of the reasons for this may be the...journal article 2023
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Cecotto, Leonardo (author), van Kessel, Kok (author), Wolfert, Margreet A. (author), Vogely, Charles (author), van der Wal, Bart (author), Weinans, Harrie (author), van Strijp, Jos (author), Amin Yavari, S. (author)Cationic host defense peptides (HDPs) are a promising alternative to antibiotics in the fight against Staphylococcus aureus infections. In this study, we investigated the antibacterial and immunomodulatory properties of three HDPs namely IDR-1018, CATH-2, and LL-37. Although all three HDPs significantly inhibited LPS-induced activation of...journal article 2022