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Kok, R.N.U. (author)How does the small intestine maintain itself? What mechanism does it use to achieve<br/>homeostasis, and how optimal is this mechanism? We approached these questions<br/>mainly using cell tracking in organoids, for which we developed new cell trackers.<br/>We found that the intestinal crypt uses a surprisingly simple and effective strategy.<br/...doctoral thesis 2024
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Endendijk, Thijs (author), Botzen, W.J. Wouter (author), de Moel, Hans (author), Slager, Kymo (author), Kok, M. (author), Aerts, Jeroen C.J.H. (author)Without taking additional measures, flooding is becoming more likely and intense in a changing climate, which causes large economic damage. Households and firms are directly impacted by physical flood damage, but further ripple effects on society occur through business disruptions. By using post-disaster survey data from the 2021 flood event in...journal article 2024
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Xu, J. (author), Vecstaudza, Jana (author), Wesdorp, Marinus A. (author), Labberté, Margot (author), Salerno, Manuela (author), Kok, Joeri (author), van Rietbergen, Bert (author), van Osch, G.J.V.M. (author), Locs, Janis (author), Brama, Pieter A.J. (author)Osteochondral defect repair with a collagen/collagen-magnesium-hydroxyapatite (Col/Col-Mg-HAp) scaffold has demonstrated good clinical results. However, subchondral bone repair remained suboptimal, potentially leading to damage to the regenerated overlying neocartilage. This study aimed to improve the bone repair potential of this scaffold by...journal article 2024
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Kok, M. (author), Solin, Arno (author), Schön, Thomas B. (author)Simultaneous localization and mapping (SLAM) is the task of building a map representation of an unknown environment while at the same time using it for positioning. A probabilistic interpretation of the SLAM task allows for incorporating prior knowledge and for operation under uncertainty. Contrary to the common practice of computing point...journal article 2024
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Hariharan Sudha, S. (author), Ragno, E. (author), Morales Napoles, O. (author), Kok, M. (author)The Netherlands has traditionally focused on managing flood risk. However, the frequent occurrence of droughts in recent years has brought attention to managing both extremes. Transitions between these opposite extremes pose additional challenges to water management, requiring a trade-off between water storage during dry periods and flood...journal article 2024
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van der Stel, Stefan D. (author), Lai, Marco (author), Groen, Harald C. (author), Witteveen, Mark (author), Kuhlmann, Koert F.D. (author), Grotenhuis, Brechtje A. (author), Kok, Niels F.M. (author), van Gastel, Mark (author), Hendriks, B.H.W. (author), Ruers, Theo J.M. (author)Introduction: Anastomotic leakage after gastrointestinal surgery has a high impact on patient's quality of life and its origin is associated with inadequate perfusion. Imaging photoplethysmography (iPPG) is a noninvasive imaging technique that measures blood-volume changes in the microvascular tissue bed and detects changes in tissue...journal article 2023
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Bennis, N.X. (author), Anderson, Jonah P. (author), Kok, Siebe M.C. (author), Daran, J.G. (author)ErCas12a is a class 2 type V CRISPR-Cas nuclease isolated from Eubacterium rectale with attractive fundamental characteristics, such as RNA self-processing capability, and lacks reach-through royalties typical for Cas nucleases. This study aims to develop a ErCas12a-mediated genome editing tool applicable in the model yeast Saccharomyces...journal article 2023
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Chiasson, David (author), Lin, Yuan (author), Kok, M. (author), Shull, Peter (author)Hyperbolic localization measures the time difference of arrivals (TDOAs) of signals to determine the location of a wireless source or receiver. Traditional methods depend on precise clock synchronization between nodes so that time measurements from independent devices can be meaningfully compared. Imperfect synchronization is often the dominant...journal article 2023
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Menzen, C.M. (author), Memmel, E.M. (author), Batselier, K. (author), Kok, M. (author)This paper presents a method for approximate Gaussian process (GP) regression with tensor networks (TNs). A parametric approximation of a GP uses a linear combination of basis functions, where the accuracy of the approximation depends on the total number of basis functions M. We develop an approach that allows us to use an exponential amount...journal article 2023
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de Bruin, P. E. (author), Kaczmarek, M.B. (author), Kok, M. (author), Hassan HosseinNia, S. (author)This study evaluates three recursive Bayesian input and state estimation algorithms, as introduced in the field of Structural Health Monitoring, for estimating modal contributions for high-tech compliant mechanisms. The aim of estimating modal contributions is the use for active vibration control. High-tech compliant motion stages allow for...journal article 2023
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Menzen, C.M. (author), Fetter, Marnix (author), Kok, M. (author)We present a mapping algorithm to compute large-scale magnetic field maps in indoor environments with approximate Gaussian process (GP) regression. Mapping the spatial variations in the ambient magnetic field can be used for 10-calization algorithms in indoor areas. To compute such a map, GP regression is a suitable tool because it provides...conference paper 2023
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Edridge, T.I. (author), Kok, M. (author)Ferromagnetic materials in indoor environments give rise to disturbances in the ambient magnetic field. Maps of these magnetic disturbances can be used for indoor localisation. A Gaussian process can be used to learn the spatially varying magnitude of the magnetic field using magnetometer measurements and information about the position of the...conference paper 2023
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Viset, F.M. (author), Helmons, R.L.J. (author), Kok, M. (author)Accurately estimating the positions of multi-agent systems in indoor environments is challenging due to the lack of Global Navigation Satelite System (GNSS) signals. Noisy measurements of position and orientation can cause the integrated position estimate to drift without bound. Previous research has proposed using magnetic field simultaneous...conference paper 2023
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van der Holst, Bart (author), Verhoeven, Gijs (author), Matthijssen, E.F. (author), Vrijlandt, Mark (author), van der Meer, A.A. (author), Plug, R.B.F. (author), Kok, Koen (author)Due to the increasing penetration of distributed energy resources, congestion problems are already emerging in Dutch distribution grids. The available flexibility of assets in the built environment could have the potential to reduce congestion if prosumers are properly incentivized by distribution grid operators (DSOs). However, it is not yet...conference paper 2023
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Eichengreen, Adva (author), Tsou, Yung Ting (author), Nasri, Maedeh (author), van Klaveren, Lisa Maria (author), Li, Boya (author), Koutamanis, A. (author), Baratchi, Mitra (author), Blijd-Hoogewys, Els (author), Kok, Joost (author), Rieffe, Carolien (author)Social connectedness at school is crucial to children's development, yet very little is known about the way it has been affected by school closures during COVID-19 pandemic. We compared pre-post lockdown levels of social connectedness at a school playground in forty-three primary school-aged children, using wearable sensors, observations,...journal article 2023
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- Iglesias van Montfort, H.P. (author), Subramanian, S.S. (author), Irtem, I.E. (author), Sassenburg, M. (author), Li, Mengran (author), Kok, J.J. (author), Middelkoop, J. (author), Burdyny, T.E. (author) journal article 2023
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Endendijk, Thijs (author), Botzen, W. J. Wouter (author), de Moel, Hans (author), Aerts, Jeroen C. J. H. (author), Slager, Kymo (author), Kok, M. (author)Flood events are expected to increase in their frequency and severity, which results in higher flood risk without additional adaptation measures. The information gained from flood risk models is essential in effective disaster risk management. However, vulnerability estimations are often a large driver of uncertainty, and flood damage is...journal article 2023
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Pol, J.C. (author), Kindermann, P.E. (author), van der Krogt, M.G. (author), van Bergeijk, Vera M. (author), Remmerswaal, G. (author), Kanning, W. (author), Jonkman, Sebastiaan N. (author), Kok, M. (author)Structural reliability analysis often considers failure mechanisms as correlated but non-interacting processes. Interacting failure mechanisms affect each others performance, and thereby the system reliability. We describe such interactions in the context of flood defenses, and analyze under which conditions such interactions have a large impact...journal article 2023
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Endendijk, Thijs (author), Botzen, W.J. Wouter (author), de Moel, Hans (author), Aerts, Jeroen C.J.H. (author), Duijndam, Sem J. (author), Slager, Kymo (author), Kolen, B. (author), Kok, M. (author)This study provides an overview of the impact of the 2021 Summer floods in the Netherlands and the assessment of the effectiveness of various adaptation measures, evacuation strategies, and their impact on society. The floods were characterized by record rainfall in the cross-border region of the Meuse and Rhine basins and resulted in...journal article 2023
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van der Voorn, Tom (author), Quist, J.N. (author), Svenfelt, Åsa (author), Kok, Kasper (author), Hickman, Robin (author), Sheppard, Stephen (author), Kanyama, Annika Carlsson (author), Banister, David (author)In the face of climate change, a major challenge is to inform and guide long-term climate change adaptation planning under deep uncertainty, while aiming at transformative change. Normative futures studies approaches, such as participatory backcasting, visioning and transition management, are increasingly applied, but their potential for climate...journal article 2023