OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum

Immune checkpoint therapy (ICT) has the power to eradicate cancer, but the mechanisms that determine effective therapy-induced immune responses are not fully understood. Here, using high-dimensional single-cell profiling, we interrogate whether the landscape of T cell states in the peripheral blood predict responses to combinatorial targeting...

Telepresence for surgical assistance and training using eXtended reality during and after pandemic periods

Existing challenges in surgical education (See one, do one, teach one) as well as the COVID-19 pandemic make it necessary to develop new ways for surgical training. Therefore, this work describes the implementation of a scalable remote solution called “TeleSTAR” using immersive, interactive and augmented reality elements which enhances...

Memory CD8⁺ T cell heterogeneity is primarily driven by pathogen-specific cues and additionally shaped by the tissue environment

SummaryFactors that govern the complex formation of memory T cells are not completelyunderstood. A better understanding of thedevelopment of memory Tcell hetero-geneity is however required to enhance vaccination and immunotherapy ap-proaches. Here we examined the impact of pathogen- and tissue-specific cueson memory CD8+T cell heterogeneity...

A remote and immersive setup for pandemic-safe surgical education

Existing challenges in surgical education (See one, do one, teach one) as well as the Covid-19 pandemic make it necessary to develop new ways for surgical training. This is also crucial for the dissemination of new technological developments. As today's live transmissions of surgeries to remote locations always come with high information loss...

Comment on ‘Is ‘re-mobilisation’ nature restoration or nature destruction? A commentary’ by I. Delgado-Fernandez, R.G.D. Davidson-Arnott & P.A. Hesp

In their recently published paper, Delgado-Fernandez et al. (2019) critically review the limitations and dangers of the relatively recent shift towards dune rejuvenation management in North-western Europe. We would like to comment on the paper from the Dutch perspective.

PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors

Background: The clinical benefit of immunotherapeutic approaches against cancer has been well established although complete responses are only observed in a minority of patients. Combination immunotherapy offers an attractive avenue to develop more effective cancer therapies by improving the efficacy and duration of the tumor-specific T-cell...

Cytofast: A workflow for visual and quantitative analysis of flow and mass cytometry data to discover immune signatures and correlations

Multi-parametric flow and mass cytometry allows exceptional high-resolution exploration of the cellular composition of the immune system. A large panel of computational tools have been developed to analyze the high-dimensional landscape of the data generated. Analysis frameworks such as FlowSOM or Cytosplore incorporate clustering and...

The contribution of cytomegalovirus infection to immune senescence is set by the infectious dose

The relationship between human cytomegalovirus (HCMV) infections and accelerated immune senescence is controversial. Whereas some studies reported a CMV-associated impaired capacity to control heterologous infections at old age, other studies could not confirm this. We hypothesized that these discrepancies might relate to the variability in the...

Measuring and modeling coastal dune development in the Netherlands

IEA wind annex XX: HAWT aerodynamic and models from wind tunnel measurements - final report

Analysis of the experimental and computational flow characteristics with respect to the augmented lift phenomenon caused by blade rotation

Modelling 3D spatial objects in a Geo-DBMS using a 3D primitive

The Bowyer-Watson algorithm; An efficient implementation in a database environment