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van Kootwijk, A. (author), Moosabeiki, Vahid (author), Cruz Saldivar, M. (author), Pahlavani, H. (author), Leeflang, M.A. (author), Kazemivand Niar, S. (author), Tümer, N. (author), Mirzaali, Mohammad J. (author), Zhou, J. (author), Zadpoor, A.A. (author)The reconstruction of large mandibular defects with optimal aesthetic and functional outcomes remains a major challenge for maxillofacial surgeons. The aim of this study was to design patient-specific mandibular reconstruction implants through a semi-automated digital workflow and to assess the effects of topology optimization on the...journal article 2022
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Putra, N.E. (author), Borg, K. G.N. (author), Diaz Payno, P.J. (author), Leeflang, M.A. (author), Klimopoulou, M. (author), Taheri, P. (author), Mol, J.M.C. (author), Fratila-Apachitei, E.L. (author), Zhou, J. (author), Zadpoor, A.A. (author)Advanced additive manufacturing techniques have been recently used to tackle the two fundamental challenges of biodegradable Fe-based bone-substituting materials, namely low rate of biodegradation and insufficient bioactivity. While additively manufactured porous iron has been somewhat successful in addressing the first challenge, the limited...journal article 2022
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Pahlavani, H. (author), Amani, M. (author), Cruz Saldivar, M. (author), Zhou, J. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Emerging multi-material 3D printing techniques enables the rational design of metamaterials with not only complex geometries but also arbitrary distributions of multiple materials within those geometries, yielding unique combinations of elastic properties. However, discovering the rare designs that lead to highly unusual combinations of...journal article 2022
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Diaz Payno, P.J. (author), Kalogeropoulou, Maria (author), Muntz, I.A.A. (author), Kingma, Esther (author), Kops, Nicole (author), D'Este, Matteo (author), Koenderink, G.H. (author), Fratila-Apachitei, E.L. (author), van Osch, G.J.V.M. (author), Zadpoor, A.A. (author)3D bioprinting is usually implemented on flat surfaces, posing serious limitations in the fabrication of multilayered curved constructs. 4D bioprinting, combining 3D bioprinting with time-dependent stimuli-induced transformation, enables the fabrication of shape-changing constructs. Here, a 4D biofabrication method is reported for cartilage...journal article 2022
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van Manen, T. (author), Moosabeiki, Vahid (author), Cruz Saldivar, M. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)4D printing of flat sheets that self-fold into architected 3D structures is a powerful origami-inspired approach for the fabrication of multi-functional devices and metamaterials. However, the opposite stiffness requirements for the folding process and the subsequent loadbearing of 3D structures impose an intrinsic limitation in designing...journal article 2022
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Putra, N.E. (author), Tigrine, A. (author), Aksakal, S. (author), de la Rosa, V. R. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additively manufacturing of porous iron offers a unique opportunity to increase its biodegradation rate by taking advantage of arbitrarily complex porous structures. Nevertheless, achieving the required biodegradation profile remains challenging due to the natural passivation of iron that decrease the biodegradation rate. Moreover, the...journal article 2022
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Dong, J. (author), Tümer, N. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zadpoor, A.A. (author), Zhou, J. (author)Porous biodegradable Mg and its alloys are considered to have a great potential to serve as ideal bone substitutes. The recent progress in additive manufacturing (AM) has prompted its application to fabricate Mg scaffolds with geometrically ordered porous structures. Extrusion-based AM, followed by debinding and sintering, has been recently...journal article 2022
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Ganjian, M. (author), Modaresifar, K. (author), Rompolas, Dionysios (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Developing high-throughput nanopatterning techniques that also allow for precise control over the dimensions of the fabricated features is essential for the study of cell-nanopattern interactions. Here, we developed a process that fulfills both of these criteria. Firstly, we used electron-beam lithography (EBL) to fabricate precisely...journal article 2022
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Kolken, H.M.A. (author), Callens, S.J.P. (author), Leeflang, M.A. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)The rational design of bone-substituting biomaterials is relatively complex because they should meet a long list of requirements for optimal performance. Meta-biomaterials are micro-architected materials that hold great promise for meeting those requirements as they offer a unique combination of mechanical, mass-transport, and biological...journal article 2022
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Kubo, Yusuke (author), Beckmann, Rainer (author), Pahlavani, H. (author), Cruz Saldivar, M. (author), Szymanski, Katharina (author), Leeflang, M.A. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author), Wruck, Christoph Jan (author), Jahr, H. (author)Background: Nuclear factor erythroid 2–related factor 2 (Nrf2) is a crucial transcription factor for cellular redox homeostasis. The association of Nrf2 with elderly female osteoporotic has yet to be fully described. The aim was to elucidate a potential age-dependent Nrf2 contribution to female osteoporosis in mice. Methods: Eighteen female...journal article 2022
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van Manen, T. (author), Ganjian, M. (author), Modaresifar, K. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Folding nanopatterned flat sheets into complex 3D structures enables the fabrication of meta-biomaterials that combine a rationally designed 3D architecture with nanoscale surface features. Self-folding is an attractive approach for realizing such materials. However, self-folded lattices are generally too compliant as there is an inherent...journal article 2022
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Cruz Saldivar, M. (author), Doubrovski, E.L. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Bio-inspired composites are a great promise for mimicking the extraordinary and highly efficient properties of natural materials. Recent developments in voxel-by-voxel 3D printing have enabled extreme levels of control over the material deposition, yielding complex micro-architected materials. However, design complexity, very large degrees of...journal article 2022
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Nouri Goushki, M. (author), Eijkel, B.I.M. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Modulation of the immune response following the implantation of biomaterials can have beneficial effects on bone regeneration. This involves complex interactions between the inflammatory and osteogenic cells. Therefore, the study of cell-cell interactions using direct co-culture models integrated with biomaterials is of great interest. This...journal article 2022
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van Manen, T. (author), Janbaz, S. (author), Jansen, K.M.B. (author), Zadpoor, A.A. (author)Shape-shifting materials are a powerful tool for the fabrication of reconfigurable materials. Upon activation, not only a change in their shape but also a large shift in their material properties can be realized. As compared with the 4D printing of 2D-to-3D shape-shifting materials, the 4D printing of reconfigurable (i.e., 3D-to-3D shape...journal article 2021
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Li, Yageng (author), Shi, Jirong (author), Jahr, H. (author), Zhou, J. (author), Zadpoor, A.A. (author), Wang, Luning (author)Additively manufactured (AM) micro-architected biodegradable metals offer a unique combination of properties that are ideal for bone regeneration including biocompatibility, a fully interconnected porous structure, and the possibility to fully regenerate bony defects with native tissue upon biodegradation. Currently, the mechanical properties...review 2021
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Jahr, H. (author), Li, Y. (author), Zhou, J. (author), Zadpoor, A.A. (author), Schröder, AKi-Uwe (author)Treating large bone defects is still a clinical challenge without perfect solution, mainly due to the unavailability of suitable bone implants. Additively manufactured (AM) absorbable porous metals provide unparalleled opportunities to realize the challenging requirements for bone-mimetic implants. Firstly, multi-scale geometries of such...review 2021
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Putra, N.E. (author), Leeflang, M.A. (author), Minneboo, M.B. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)Extrusion-based 3D printing followed by debinding and sintering is a powerful approach that allows for the fabrication of porous scaffolds from materials (or material combinations) that are otherwise very challenging to process using other additive manufacturing techniques. Iron is one of the materials that have been recently shown to be...journal article 2021
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Kolken, H.M.A. (author), de Jonge, C.P. (author), van der Sloten, T. (author), Garcia, A. Fontecha (author), Pouran, B. (author), Willemsen, K. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)The unprecedented properties of meta-biomaterials could pave the way for the development of life-lasting orthopedic implants. Here, we used non-auxetic meta-biomaterials to address the shortcomings of the current treatment options in acetabular revision surgery. Due to the severe bone deficiencies and poor bone quality, it can be very...journal article 2021
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Fazel, M. (author), Salimijazi, Hamid R. (author), Shamanian, Morteza (author), Minneboo, M.B. (author), Modaresifar, K. (author), van Hengel, I.A.J. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)The recently developed additively manufacturing techniques have enabled the fabrication of porous biomaterials that mimic the characteristics of the native bone, thereby avoiding stress shielding and facilitating bony ingrowth. However, aseptic loosening and bacterial infection, as the leading causes of implant failure, need to be further...journal article 2021
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Angeloni, L. (author), Ganjian, M. (author), Nouri Goushki, M. (author), Mirzaali, Mohammad J. (author), Hagen, C.W. (author), Zadpoor, A.A. (author), Fratila-Apachitei, E.L. (author), Ghatkesar, M.K. (author)Micro- and nano-patterns are gaining increasing attraction in several fields ranging from nanoelectronics to bioengineering. The mechanical properties of the nanostructures (nanopillars, nanotubes, nanowires, etc.) are highly relevant for many applications but challenging to determine. Existing mechanical characterization methods require...journal article 2021