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Dong, J. (author), Tümer, N. (author), Putra, N.E. (author), Zhu, Jia-Ning (author), Li, Y. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zadpoor, A.A. (author), Zhou, J. (author)Additively manufactured (AM) biodegradable magnesium (Mg) scaffolds with precisely controlled and fully interconnected porous structures offer unprecedented potential as temporary bone substitutes and for bone regeneration in critical-sized bone defects. However, current attempts to apply AM techniques, mainly powder bed fusion AM, for the...journal article 2021
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Mirzaali, Mohammad J. (author), Ghorbani, Aref (author), Nakatani, Kenichi (author), Nouri Goushki, M. (author), Tümer, N. (author), Callens, S.J.P. (author), Janbaz, S. (author), Accardo, A. (author), Bico, José (author), Habibi, Mehdi (author), Zadpoor, A.A. (author)The design of advanced functional devices often requires the use of intrinsically curved geometries that belong to the realm of non-Euclidean geometry and remain a challenge for traditional engineering approaches. Here, it is shown how the simple deflection of thick meta-plates based on hexagonal cellular mesostructures can be used to achieve...journal article 2021
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Putra, N.E. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additively manufactured biodegradable porous iron has been only very recently demonstrated. Two major limitations of such a biomaterial are very low biodegradability and incompatibility with magnetic resonance imaging (MRI). Here, we present a novel biomaterial that resolves both of those limitations. We used extrusion-based 3D printing to...journal article 2021
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Callens, S.J.P. (author), Tourolle né Betts, Duncan C. (author), Müller, Ralph (author), Zadpoor, A.A. (author)The organization and shape of the microstructural elements of trabecular bone govern its physical properties, are implicated in bone disease, and serve as blueprints for biomaterial design. To devise fundamental structure-property relationships and design truly bone-mimicking biomaterials, it is essential to characterize trabecular bone...journal article 2021
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Pouran, Behdad (author), Raoof, Amir (author), de Winter, D. A.Matthijs (author), Arbabi, V. (author), Bleys, Ronald L.A.W. (author), Beekman, F.J. (author), Zadpoor, A.A. (author), Malda, Jos (author), Weinans, Harrie (author)Recent insights suggest that the osteochondral interface plays a central role in maintaining healthy articulating joints. Uncovering the underlying transport mechanisms is key to the understanding of the cross-talk between articular cartilage and subchondral bone. Here, we describe the mechanisms that facilitate transport at the osteochondral...journal article 2021
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Naghavi Zadeh, S.M. (author), Alijani, F. (author), Chen, X. (author), Dayyani, Iman (author), Yasaee, Mehdi (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Mechanical metamaterials are advanced engineering materials that exhibit unusual properties that cannot be found in nature. The elastic properties (i.e., elastic modulus and Poisson's ratio) of mechanical metamaterials can be tuned by changing the geometry of their fundamental unit cells. This allows for the design of metamaterial lattices...journal article 2021
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Dimaraki, A. (author), Diaz Payno, P.J. (author), Minneboo, M.B. (author), Nouri Goushki, M. (author), Hosseini, M. (author), Kops, N. (author), Narcisi, R. (author), Mirzaali, Mohammad J. (author), van Osch, G.J.V.M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The treatment of articular cartilage defects remains a significant clinical challenge. This is partially due to current tissue engineering strategies failing to recapitulate native organization. Articular cartilage is a graded tissue with three layers exhibiting different cell densities: the superficial zone having the highest density and the...journal article 2021
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Nouri Goushki, M. (author), Isaakidou, A. (author), Eijkel, B.I.M. (author), Minneboo, M.B. (author), Liu, Q. (author), Boukany, P. (author), Mirzaali, Mohammad J. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The surface topography of engineered extracellular matrices is one of the most important physical cues regulating the phenotypic polarization of macrophages. However, not much is known about the ways through which submicron (i.e., 100-1000 nm) topographies modulate the polarization of macrophages. In the context of bone tissue regeneration,...journal article 2021
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Modaresifar, K. (author), Ganjian, M. (author), Angeloni, L. (author), Minneboo, M.B. (author), Ghatkesar, M.K. (author), Hagedoorn, P.L. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Despite the potential of small-scale pillars of black titanium (bTi) for killing the bacteria and directing the fate of stem cells, not much is known about the effects of the pillars’ design parameters on their biological properties. Here, three distinct bTi surfaces are designed and fabricated through dry etching of the titanium, each...journal article 2021
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Salandova, M. (author), van Hengel, I.A.J. (author), Apachitei, I. (author), Zadpoor, A.A. (author), van der Eerden, B.C.J. (author), Fratila-Apachitei, E.L. (author)Aseptic loosening of a permanent prosthesis remains one of the most common reasons for bone implant failure. To improve the fixation between implant and bone tissue as well as enhance blood vessel formation, bioactive agents are incorporated into the surface of the biomaterial. This study reviews and compares five bioactive elements (copper,...review 2021
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Kolken, H.M.A. (author), Garcia, A. Fontecha (author), Du Plessis, A. (author), Rans, C.D. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Meta-biomaterials offer a promising route towards the development of life-lasting implants. The concept aims to achieve solutions that are ordinarily impossible, by offering a unique combination of mechanical, mass transport, and biological properties through the optimization of their small-scale geometrical and topological designs. In this...journal article 2021
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Callens, S.J.P. (author), Arns, Christoph H. (author), Kuliesh, Alina (author), Zadpoor, A.A. (author)Rapid advances in additive manufacturing have kindled widespread interest in the rational design of metamaterials with unique properties over the past decade. However, many applications require multi-physics metamaterials, where multiple properties are simultaneously optimized. This is challenging since different properties, such as...journal article 2021
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Oldhoff, M. G.E. (author), Mirzaali, Mohammad J. (author), Tümer, N. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additive manufacturing (AM) offers great design freedom that enables objects with desired unique and complex geometry and topology to be readily and cost-effectively fabricated. The overall benefits of AM are well known, such as increased material and resource efficiency, enhanced design and production flexibility, the ability to create...journal article 2021
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Gijsen, F.J.H. (author), Vis, Bas (author), Barrett, Hilary E. (author), Zadpoor, A.A. (author), Verhagen, Hence J. (author), Bos, Daniel (author), van der Steen, A.F.W. (author), Akyildiz, A.C. (author)Objective: Atherosclerotic plaque rupture in carotid arteries is a major source of cerebrovascular events. Calcifications are highly prevalent in carotid plaques, but their role in plaque rupture remains poorly understood. This work studied the morphometric features of calcifications in carotid plaques and their effect on the stress...journal article 2021
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Cuellar Lopez, J.S. (author), Plettenburg, D.H. (author), Zadpoor, A.A. (author), Breedveld, P. (author), Smit, G. (author)Various upper-limb prostheses have been designed for 3D printing but only a few of them are based on bio-inspired design principles and many anatomical details are not typically incorporated even though 3D printing offers advantages that facilitate the application of such design principles. We therefore aimed to apply a bio-inspired approach...journal article 2021
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van Hengel, I.A.J. (author), Tierolf, M.W.A.M. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Patients receiving orthopedic implants are at risk of implant-associated infections (IAI). A growing number of antibiotic-resistant bacteria threaten to hamper the treatment of IAI. The focus has, therefore, shifted towards the development of implants with intrinsic antibacterial activity to prevent the occurrence of infection. The use of Ag, Cu...review 2021
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van Hengel, I.A.J. (author), Lacin, M. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Surface biofunctionalization is frequently applied to enhance the functionality and longevity of orthopedic implants. Here, we investigated the osteogenic effects of additively manufactured porous Ti6Al4V implants whose surfaces were biofunctionalized using plasma electrolytic oxidation (PEO) in Ca/P-based electrolytes with or without...journal article 2021
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Nouri Goushki, M. (author), Angeloni, L. (author), Modaresifar, K. (author), Minneboo, M.B. (author), Boukany, P. (author), Mirzaali, Mohammad J. (author), Ghatkesar, M.K. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The surface topography of implantable devices is of crucial importance for guiding the cascade of events that starts from the initial contact of the cells with the surface and continues until the complete integration of the device in its immediate environment. There is, however, limited quantitative information available regarding the...journal article 2021
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Additive manufacturing of non-assembly deployable mechanisms for the treatment of large bony defectsLeeflang, M.A. (author), Bobbert, F.S.L. (author), Zadpoor, A.A. (author)Porous biomaterials are often used to treat large bony defects or fractured vertebras. Most of such biomaterials are made of metals and their alloys and have a pre-defined, fixed shape. Due to their predefined fixed shape, however, they are not suitable for implantation through minimally invasive surgical procedures. To overcome this problem,...journal article 2021
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Zadpoor, A.A. (author)Meta-biomaterials are designer biomaterials with unusual and even unprecedented properties that primarily originate from their geometrical designs at different (usually smaller) length scales. This concept has been primarily used in the context of orthopedic biomaterials with the ultimate aim of improving the bone tissue regeneration performance...journal article 2020