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Nijhuis, Wouter (author), Verhoef, Marjolein (author), van Bergen, Christiaan (author), Weinans, Harrie (author), Sakkers, Ralph (author)Fractures in patients with osteogenesis imperfecta (OI) are caused by a decreased strength of bone due to a decreased quality and quantity of bone matrix and architecture. Mutations in the collagen type 1 encoding genes cause the altered formation of collagen type I, one of the principal building blocks of bone tissue. Due to the complexity...journal article 2022
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van Dijk, Bruce (author), Nurmohamed, F. Ruben H.A. (author), Hooning van Duyvenbode, J. Fred F. (author), Veltman, Ewout S. (author), Rentenaar, Rob J. (author), Weinans, Harrie (author), Vogely, H. Charles (author), van der Wal, Bart C.H. (author)Background and purpose — The long-term results of the 1-or 2-stage revision procedure and infection-free prosthesis survival in a tertiary referral center are unknown. In this retrospective observational study, the long-term results of infection control and infection-free prosthesis survival of the peri-prosthetic joint infection-related 1...journal article 2022
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Willemsen, Koen (author), Tryfonidou, Marianna A. (author), Sakkers, Ralph J.B. (author), Castelein, René M. (author), Beukers, Martijn (author), Seevinck, Peter R. (author), Weinans, Harrie (author), van der Wal, Bart C.H. (author), Meij, Björn P. (author)The concept of a novel patient-specific 3D-printed shelf implant should be evaluated in a relevant large animal model with hip dysplasia. Therefore, three dogs with radiographic bilateral hip dysplasia and a positive subluxation test underwent unilateral acetabular augmentation with a 3D-printed dog-specific titanium implant. The...journal article 2022
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Willemsen, Koen (author), Magré, Joëll (author), Mol, Jeroen (author), Noordmans, Herke Jan (author), Weinans, Harrie (author), Hekman, Edsko E.G. (author), Kruyt, Moyo C. (author)For decades, the advantages of rapid prototyping for clinical use have been recognized. However, demonstrations of potential solutions to treat spinal problems that cannot be solved otherwise are scarce. In this paper, we describe the development, regulatory process, and clinical application of two types of patient specific 3D-printed devices...journal article 2022
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Current Evidence for Spinopelvic Characteristics Influencing Total Hip Arthroplasty Dislocation Riskvan der Gronde, B. A.T.D. (author), Schlösser, T. P.C. (author), van Erp, J. H.J. (author), Snijders, T. E. (author), Castelein, R. M. (author), Weinans, Harrie (author), de Gast, A. (author)BACKGROUND: Decreased pelvic mobility and pelvic retroversion may result from spinal degeneration and lead to changes in the orientation of the acetabular implant after total hip arthroplasty (THA). While multiple patient and surgery-related factors contribute to THA dislocations, there is increasing evidence that sagittal spinopelvic...review 2022
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de Vor, Lisanne (author), van Dijk, Bruce (author), van Kessel, Kok (author), Kavanaugh, Jeffrey S. (author), de Haas, Carla (author), Aerts, Piet C. (author), Ramakers, R.M. (author), Beekman, F.J. (author), Weinans, Harrie (author)Implant-associated Staphylococcus aureus infections are difficult to treat because of biofilm formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity. Monoclonal antibodies (mAbs) could provide an alternative approach to improve the diagnosis and potential treatment of biofilm-related infections. Here, we show...journal article 2022
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Cecotto, Leonardo (author), van Kessel, Kok (author), Wolfert, Margreet A. (author), Vogely, Charles (author), van der Wal, Bart (author), Weinans, Harrie (author), van Strijp, Jos (author), Amin Yavari, S. (author)Cationic host defense peptides (HDPs) are a promising alternative to antibiotics in the fight against Staphylococcus aureus infections. In this study, we investigated the antibacterial and immunomodulatory properties of three HDPs namely IDR-1018, CATH-2, and LL-37. Although all three HDPs significantly inhibited LPS-induced activation of...journal article 2022
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Willemsen, Koen (author), Niemeyer, Menco J.S. (author), Harlianto, Netanja I. (author), Sadiqi, Said (author), Seevinck, Peter R. (author), Sakkers, Ralph J.B. (author), Weinans, Harrie (author), Van der Wal, Bart C.H. (author)BACKGROUND AND PURPOSE: The Chiari osteotomy was a regular treatment for developmental hip dysplasia before it became mostly reserved as a salvage therapy. However, the long-term survival of the Chiari osteotomy has not been systematically investigated. We investigated the survival time of the Chiari osteotomy until conversion to total hip...journal article 2022
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Arbabi, Saeed (author), Seevinck, Peter (author), Weinans, Harrie (author), de, Pim A. (author), Sturkenboom, Joran (author), van Hamersvelt, Robbert W. (author), Foppen, Wouter (author), Arbabi, Vahid (author)Diagnosis of ankle impingement is performed primarily by clinical examination, whereas medical imaging is used for severity staging and treatment guidance. The association of impingement symptoms with regional three-dimensional (3D) bone shape variaties visible in medical images has not been systematically explored, nor do we know the type...journal article 2022
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Kolken, H.M.A. (author), de Jonge, C.P. (author), van der Sloten, T. (author), Garcia, A. Fontecha (author), Pouran, B. (author), Willemsen, K. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)The unprecedented properties of meta-biomaterials could pave the way for the development of life-lasting orthopedic implants. Here, we used non-auxetic meta-biomaterials to address the shortcomings of the current treatment options in acetabular revision surgery. Due to the severe bone deficiencies and poor bone quality, it can be very...journal article 2021
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van Buuren, M.M.A. (author), Arden, N. K. (author), Bierma-Zeinstra, S. M.A. (author), Bramer, W. M. (author), Casartelli, N. C. (author), Felson, D. T. (author), Jones, G. (author), Lane, N. E. (author), Lindner, C. (author), Weinans, Harrie (author)Objective: To summarize available evidence on the association between hip shape as quantified by statistical shape modeling (SSM) and the incidence or progression of hip osteoarthritis. Design: We conducted a systematic search of five electronic databases, based on a registered protocol (available: PROSPERO CRD42020145411). Articles...review 2021
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Snijders, Thom E. (author), Schlösser, Tom P.C. (author), Heckmann, Nathanael D. (author), Tezuka, Taro (author), Castelein, Rene M. (author), Stevenson, Rob P. (author), Weinans, Harrie (author), de Gast, Arthur (author), Dorr, Lawrence D. (author)Background: Anterior and posterior pelvic tilt appears to play a role in total hip arthroplasty (THA) stability. When changing from the standing to the sitting position, the pelvis typically rotates posteriorly while the hips flex and this affects the femoro-acetabular positions. This case-control study compares changes in 3-D acetabular cup...journal article 2021
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Bhattarai, Abhisek (author), Mäkelä, Janne T.A. (author), Pouran, Behdad (author), Kröger, Heikki (author), Weinans, Harrie (author), Grinstaff, Mark W. (author), Töyräs, Juha (author), Turunen, Mikael J. (author)Contrast-enhanced computed tomography is an emerging diagnostic technique for osteoarthritis. However, the effects of increased water content, as well as decreased collagen and proteoglycan concentrations due to cartilage degeneration, on the diffusion of cationic and nonionic agents, are not fully understood. We hypothesize that for a...journal article 2021
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Golafshan, Nasim (author), Willemsen, K. (author), Kadumudi, Firoz Babu (author), Vorndran, Elke (author), Dolatshahi-Pirouz, Alireza (author), Weinans, Harrie (author), van der Wal, Bart C.H. (author), Malda, Jos (author), Castilho, Miguel (author)Osteoarthritis of the hip is a painful and debilitating condition commonly occurring in humans and dogs. One of the main causes that leads to hip osteoarthritis is hip dysplasia. Although the current surgical methods to correct dysplasia work satisfactorily in many circumstances, these are associated with serious complications, tissue...journal article 2021
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Pouran, Behdad (author), Raoof, Amir (author), de Winter, D. A.Matthijs (author), Arbabi, V. (author), Bleys, Ronald L.A.W. (author), Beekman, F.J. (author), Zadpoor, A.A. (author), Malda, Jos (author), Weinans, Harrie (author)Recent insights suggest that the osteochondral interface plays a central role in maintaining healthy articulating joints. Uncovering the underlying transport mechanisms is key to the understanding of the cross-talk between articular cartilage and subchondral bone. Here, we describe the mechanisms that facilitate transport at the osteochondral...journal article 2021
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Willemsen, K. (author), Möring, Michelle M. (author), Harlianto, Netanja I. (author), Tryfonidou, Marianna A. (author), van der Wal, Bart C.H. (author), Weinans, Harrie (author), Meij, Björn P. (author), Sakkers, Ralph J. B. (author)Hip dysplasia (HD) is common in both humans and dogs. This interconnection is because humans and dogs descended from a common ancestor and therefore have a similar anatomy at micro- and macroscopic levels. Furthermore, dogs are the animals of choice for testing new treatments for human hip dysplasia and orthopedic surgery in general. However,...review 2021
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Saukko, Annina E.A. (author), Nykänen, Olli (author), Sarin, Jaakko K. (author), Nissi, Mikko J. (author), te Moller, Nikae C.R. (author), Weinans, Harrie (author), Mancini, Irina A.D. (author), Visser, Jetze (author), Brommer, Harold (author)To prevent the progression of posttraumatic osteoarthritis, assessment of cartilage composition is critical for effective treatment planning. Posttraumatic changes include proteoglycan (PG) loss and elevated water content. Quantitative dual-energy computed tomography (QDECT) provides a means to diagnose these changes. Here, we determine the...journal article 2021
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Nurmohamed, F. Ruben H.A. (author), Van Dijk, Bruce (author), Veltman, Ewout S. (author), Hoekstra, Marrit (author), Rentenaar, Rob J. (author), Weinans, Harrie (author), Vogely, H. Charles (author), Van Der Wal, Bart C.H. (author)Introduction: Debridement, antibiotics and implant retention (DAIR) procedures are effective treatments for acute postoperative or acute hematogenous periprosthetic joint infections. However, literature reporting on the effectiveness of DAIR procedures performed after a one- or two-stage revision because of a prosthetic joint infection (PJI) ...journal article 2021
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van Erp, Joost H.J. (author), Snijders, Thom E. (author), Weinans, Harrie (author), Castelein, René M. (author), Schlösser, Tom P.C. (author), de Gast, Arthur (author)Introduction: Dislocation remains a major complication in total hip arthroplasty (THA), in which femoral component orientation is considered a key parameter. New imaging modalities and definitions on femoral component orientation have been introduced, describing orientation in different planes. This study aims to systematically review the...review 2021
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Khokhani, Paree (author), Rahmani, Nada R. (author), Kok, Anne (author), Öner, F. Cumhur (author), Alblas, Jacqueline (author), Weinans, Harrie (author), Kruyt, Moyo C. (author), Croes, Michiel (author)Therapeutic pathogen recognition receptor (PRR) ligands are reaching clinical practice following their ability to skew the immune response in a specific direction. We investigated the effects of various therapeutic PRR ligands on bone cell differentiation and inflammation. Following stimu-lation, alkaline phosphatase (ALP) activity (Day 10),...journal article 2021