Small-angle neutron scattering (SANS) and spinecho SANS measurements reveal the logarithmic fractal structure of the large-scale chromatin organization in HeLa nuclei

This paper reports on the two-scale fractal structure of chromatin organization in the nucleus of the HeLa cell. Two neutron scattering methods, small-angle neutron scattering (SANS) and spin-echo SANS, are used to unambiguously identify the large-scale structure as being a logarithmic fractal with the correlation function (r) - ln(r/E). The...

Dissecting the Nucleosome: Single-Molecule Studies of Subnucleosomal Structure and Dynamics

The entire blueprint of all living things is encoded in their genomes, which consist of DNA strands. The genome of a complex organism like ourselves can be several meters long. One of the miracles of nature is that such DNA molecules can be stored in the micron-sized nucleus of eukaryotic cells. For this purpose, the relatively large genome of...