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Tümer, N. (author), Vuurberg, Gwendolyn (author), Blankevoort, Leendert (author), Kerkhoffs, Gino M.M.J. (author), Tuijthof, G.J.M. (author), Zadpoor, A.A. (author)Bone shapes, particularly those defining the subtalar joint (STJ), have not received much attention yet as a risk factor for developing chronic ankle instability (CAI) after sustaining a lateral ankle sprain (LAS). This study aimed to compare three-dimensional (3D) shape variations in the STJ bones within individuals with CAI and healthy...journal article 2019
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Mirzaali, Mohammad J. (author), Herranz de la Nava, Alba (author), Gunashekar, Deepthishre (author), Nouri Goushki, M. (author), Doubrovski, E.L. (author), Zadpoor, A.A. (author)The functional gradient is a concept often occurring in nature. This concept can be implemented in the design and fabrication of advanced materials with specific functionalities and properties. Functionally graded materials (FGMs) can effectively eliminate the interface problems in extremely hard–soft connections, and, thus, have numerous and...journal article 2019
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Cuellar Lopez, J.S. (author), Smit, G. (author), Breedveld, P. (author), Zadpoor, A.A. (author), Plettenburg, D.H. (author)In developing countries, the access of amputees to prosthetic devices is very limited. In a way to increase accessibility of prosthetic hands, we have recently developed a new approach for the design and 3D printing of non-assembly active hand prostheses using inexpensive 3D printers working on the basis of material extrusion technology. This...journal article 2019
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Tümer, N. (author), Arbabi, V. (author), Gielis, Willem Paul (author), de Jong, Pim A. (author), Weinans, Harrie (author), Tuijthof, Gabrielle J.M. (author), Zadpoor, A.A. (author)The bones forming the talocrural joint (TCJ) and subtalar joint (STJ) are often assumed to be bilaterally symmetric. Therefore, the contralateral limb (i.e. the fibula, tibia, calcaneus and talus) is used as a template or an intra-subject control in clinical and research practice. However, the validity of the symmetry assumption is...journal article 2019
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Li, Y. (author), Lietaert, K. (author), Li, W. (author), Zhang, X.Y. (author), Leeflang, M.A. (author), Zhou, J. (author), Zadpoor, A.A. (author)The corrosion fatigue behavior of additively manufactured topologically ordered porous iron based on diamond unit cells was studied for the first time to understand its response to cyclic loading in a simulated physiological environment. The material exhibited high fatigue resistance with fatigue strengths being 70% and 65% of yield stress in...journal article 2019
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Ganjian, M. (author), Modaresifar, K. (author), Zhang, H. (author), Hagedoorn, P.L. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)One of the major problems with the bone implant surfaces after surgery is the competition of host and bacterial cells to adhere to the implant surfaces. To keep the implants safe against implant-associated infections, the implant surface may be decorated with bactericidal nanostructures. Therefore, fabrication of nanostructures on...journal article 2019
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Nouri Goushki, M. (author), Sharma, Abhishek (author), Sasso, L. (author), Zhang, Shuang (author), van der Eerden, B.C.J. (author), Staufer, U. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Manufacturing high throughput in vitro models resembling the tissue microenvironment is highly demanded for studying bone regeneration. Tissues such as bone have complex multiscale architectures inside which cells reside. To this end, engineering a microfluidic platform incorporated with three-dimensional (3D) microscaffolds and submicron...journal article 2019
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Pouran, B. (author), Moshtagh, Parisa R. (author), Arbabi, V. (author), Snabel, Jessica (author), Stoop, Reinout (author), Ruberti, Jeffrey (author), Malda, Jos (author), Zadpoor, A.A. (author), Weinans, Harrie (author)An important aspect in cartilage ageing is accumulation of advanced glycation end products (AGEs) after exposure to sugars. Advanced glycation results in cross-links formation between the collagen fibrils in articular cartilage, hampering their flexibility and making cartilage more brittle. In the current study, we investigate whether...journal article 2018
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Hedayati, R. (author), Mirzaali, Mohammad J. (author), Vergani, L. (author), Zadpoor, A.A. (author)Mechanical metamaterials are a sub-category of designer materials where the geometry of the material at the small-scale is rationally designed to give rise to unusual properties and functionalities. Here, we propose the concept of "action-at-a-distance" metamaterials where a specific pattern of local deformation is programmed into the fabric...journal article 2018
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Hedayati, R. (author), Ahmadi, S.M. (author), Lietaert, K. (author), Tümer, N. (author), Li, Y (author), Amin Yavari, S. (author), Zadpoor, A.A. (author)Magnesium and its alloys have the intrinsic capability of degrading over time in vivo without leaving toxic degradation products. They are therefore suitable for use as biodegradable scaffolds that are replaced by the regenerated tissues. One of the main concerns for such applications, particularly in load-bearing areas, is the sufficient...journal article 2018
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Ahmadi, S.M. (author), Hedayati, R. (author), Li, Y (author), Lietaert, K. (author), Tümer, N. (author), Fatemi, A. (author), Rans, C.D. (author), Pouran, B. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)Additive manufacturing (AM) techniques enable fabrication of bone-mimicking meta-biomaterials with unprecedented combinations of topological, mechanical, and mass transport properties. The mechanical performance of AM meta-biomaterials is a direct function of their topological design. It is, however, not clear to what extent the material type...journal article 2018
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Hedayati, R. (author), Hosseini-Toudeshky, H. (author), Sadighi, M. (author), Mohammadi-Aghdam, M. (author), Zadpoor, A.A. (author)Advances in additive manufacturing (AM) techniques have enabled fabrication of highly porous titanium implants that combine the excellent biocompatibility of bulk titanium with all the benefits that a regular volume-porous structure has to offer (e.g. lower stiffness values comparable to those of bone). Clinical application of such...journal article 2018
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Tümer, N. (author), Kok, A.C. (author), Vos, F.M. (author), Streekstra, Geert J. (author), Askeland, Christian (author), Tuijthof, G.J.M. (author), Zadpoor, A.A. (author)A rigid surface–volume registration scheme is presented in this study to register computed tomography (CT) and free-hand tracked ultrasound (US) images of the talocrural joint. Prior to registration, bone surfaces expected to be visible in US are extracted from the CT volume and bone contours in 2D US data are enhanced based on monogenic signal...journal article 2018
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Bobbert, F.S.L. (author), Janbaz, S. (author), Zadpoor, A.A. (author)Meta-biomaterials exhibit unprecedented or rare combinations of properties not usually found in nature. Such unusual mechanical, mass transport, and biological properties could be used to develop novel categories of orthopedic implants with superior performance, otherwise known as meta-implants. Here, we use bi-stable elements working on the...journal article 2018
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Koolen, Marianne K.E. (author), Pouran, B. (author), Oner, Fetullah C. (author), Zadpoor, A.A. (author), van der Jagt, Olav P. (author), Weinans, Harrie (author)Bone substitutes are frequently used in clinical practice but often exhibit limited osteoinductivity. We hypothesized that unfocused shockwaves enhance the osteoinductivity of bone substitutes and improve osteointegration and angiogenesis. Three different bone substitutes, namely porous tricalcium phosphate, porous hydroxyapatite and porous...journal article 2018
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Janbaz, S. (author), McGuinness, M.M.S. (author), Zadpoor, A.A. (author)Soft mechanical metamaterials working on the basis of instability have numerous potential applications in the context of "machine materials." Controlling the onset of instability is usually required when rationally designing such metamaterials. We study the isolated and modulated effects of geometrical design and material distribution on the...journal article 2018
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Zadpoor, A.A. (author)There has been a growing interest in metallic biomaterials during the last five years, as recent developments in additive manufacturing (=3D printing), surface bio-functionalization techniques, infection prevention strategies, biodegradable metallic biomaterials, and composite biomaterials have provided many possibilities to develop...contribution to periodical 2018
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De Witte, Tinke (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Peppas, Nicholas (author)In recent years, bone tissue engineering has emerged as a promising solution to the limitations of current gold standard treatment options for bone related-disorders such as bone grafts. Bone tissue engineering provides a scaffold design that mimics the extracellular matrix, providing an architecture that guides the natural bone regeneration...journal article 2018
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Mirzaali, Mohammad J. (author), Van Dongen, I. C.P. (author), Tümer, N. (author), Weinans, Harrie (author), Amin Yavari, S. (author), Zadpoor, A.A. (author)Nanopillar arrays that are bactericidal but not cytotoxic against the host cells could be used in implantable medical devices to prevent implant-associated infections. It is, however, unclear what heights, widths, interspacing, and shape should be used for the nanopillars to achieve the desired antibacterial effects while not hampering the...journal article 2018
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Hammann, C.P.W. (author), Heerkens, C.T.H. (author), Hagen, C.W. (author), Zadpoor, A.A. (author), Fratila-Apachitei, E.L. (author)Recent research evidences the strong modulatory role of controlled submicron and nanoscale topographies on stem cells fate. To harness these physical surface cues for clinical applications, fabrication of nano- and submicron patterns on clinically relevant biomaterials is greatly needed. In this study, an electron beam lithography method for...journal article 2018