Focal-plane wavefront sensing with high-order adaptive optics systems

We investigate methods to calibrate the non-common path aberrations at an adaptive optics system having a wavefront-correcting device working with an extremely high resolution (larger than 150x150 correcting elements). We use focal-plane images collected successively, the corresponding phase-diversity information and numerically efficient...

Fast & Furious focal-plane wavefront sensing

We present two complementary algorithms suitable for using focal-plane measurements to control a wavefront corrector with an extremely high-spatial resolution. The algorithms use linear approximations to iteratively minimize the aberrations seen by the focal-plane camera. The first algorithm, Fast & Furious (FF), uses a weak-aberration...

Optimization-based wavefront sensorless adaptive optics for multiphoton microscopy

Optical aberrations have detrimental effects in multiphoton microscopy. These effects can be curtailed by implementing model-based wavefront sensorless adaptive optics, which only requires the addition of a wavefront shaping device, such as a deformable mirror (DM) to an existing microscope. The aberration correction is achieved by maximizing a...

Snapshot coherence-gated direct wavefront sensing for multi-photon microscopy

Deep imaging in turbid media such as biological tissue is challenging due to scattering and optical aberrations. Adaptive optics has the potential to compensate the tissue aberrations. We present a wavefront sensing scheme for multi-photon scanning microscopes using the pulsed, near-infrared light reflected back from the sample utilising...

Iterative linear focal-plane wavefront correction

We propose an efficient approximation to the nonlinear phase diversity (PD) method for wavefront reconstruction and correction from intensity measurements with potential of being used in real-time applications. The new iterative linear phase diversity (ILPD) method assumes that the residual phase aberration is small and makes use of a first...

Semidefinite programming for model-based sensorless adaptive optics

Wavefront sensorless adaptive optics methodologies are widely considered in scanning fluorescence microscopy where direct wavefront sensing is challenging. In these methodologies, aberration correction is performed by sequentially changing the settings of the adaptive element until a predetermined image quality metric is optimized. An efficient...

Joint optimization of phase diversity and adaptive optics: Demonstration of potential

We study different possibilities to use adaptive optics (AO) and phase diversity (PD) together in a jointly optimized system. The potential of the joint system is demonstrated through numerical simulations. We find that the most significant benefits are obtained from the improved deconvolution of AO-corrected wavefronts and the additional...