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Goorden, M.C. (author), Beekman, F.J. (author)State-of-the-art small-animal single photon emission computed tomography (SPECT) enables sub-half-mm resolution imaging of radio-labelled molecules. Due to severe photon penetration through pinhole edges, current multi-pinhole SPECT is not suitable for high-resolution imaging of photons with high energies, such as the annihilation photons...journal article 2010
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Goorden, M.C. (author), Rentmeester, M.C.M. (author), Beekman, F.J. (author)Presently used clinical brain SPECT suffers from limited spatio-temporal resolution. Here we investigate the feasibility of high-resolution and high-sensitivity full-ring multi-pinhole brain SPECT (MP-SPECT). Using an analytical model we optimized pinhole-detector geometries of MP-SPECT for different detector intrinsic resolutions Ri. System...journal article 2009