Integration of metabolomics with genomics: Metabolic gene prioritization using metabolomics data and genomic variant (CADD) scores

The integration of metabolomics data with sequencing data is a key step towards improving the diagnostic process for finding the disease-causing genetic variant(s) in patients suspected of having an inborn error of metabolism (IEM). The measured metabolite levels could provide additional phenotypical evidence to elucidate the degree of...

GeoBIM information to check digital building permit regulations

Municipalities invest a lot of time and person-hours into manual building permit checks. With the increase in computational power and the use of Building Information Models (BIM) in the building design life cycle, several municipalities are investing in automating these checks using BIM and geo-data sets. However, few examples exist of tools...

Scales of application of the WEF nexus approach

Water, energy, and food (WEF) systems form a complex interconnected network, operational at scales from the household up to the global. These scales, like the nexus sectors themselves, and mutually interconnected, with lower-level characteristics help drive higher-level resource management, and vice versa. This chapter highlights recent WEF...

Tools and indices for WEF nexus analysis

The water-energy-food (WEF) nexus is shown to be a highly interconnected, complex system, operating over multiple time scales, and at spatial scales from household to global. The key WEF nexus foci issues and challenges are known to be extremely diverse and change depending on the local situation and setting, the scale at which the nexus is...

Single-cell Analysis from the perspective of how to Interact, Identify and Integrate cells

Single-cell technologies have emerged as powerful tools to analyze complex tissues at the single-cell resolution, resolving the cellular heterogeneity within a tissue through the discovery of different cell populations. Over the past decade, single-cell technologies have greatly developed allowing the profiling of various molecular features...

Integrating Massive Data Streams

Data Integration has been a long-standing and challenging problem for enterprises and researchers. Data residing in multiple heterogeneous sources must be integrated and prepared such that the valuable information that it carries, can be extracted and analysed. However, the volume and the velocity of the produced data in addition to the modern...

A web-based decision support system for aircraft dispatch and maintenance

Aircraft dispatch involves determining the optimal dispatch option when an aircraft experiences an unexpected failure. Currently, maintenance technicians at the apron have limited access to support information and finding the right information in extensive maintenance manuals is a time-consuming task, often leading to technically induced...

A decision support framework and prototype for aircraft dispatch assessment

When an aircraft experiences an unexpected issue during flight operations, a technician determines whether the aircraft can safely perform the next flight. This operational decision process - known as dispatch assessment - has to happen within limited available time between aircraft arrival and departure. Currently, technicians face two main...

The reciprocity of data integration in disaster risk analysis

Humanitarian organizations are increasingly challenged by the amount of data available to drive their decisions. Useful data can come from many sources, exists in different formats, and merging it into a basis for analysis and planning often exceeds organizations’ capacities and resources. At the same time, affected communities’ participation in...

Integration of infrared thermography & photogrammetric surveying of built landscape

The thermal analysis of buildings represents a key-step for reduction of energy consumption, also in the case of Cultural Heritage. Here the complexity of the constructions and the adopted materials might require special analysis and tailored solutions. Infrared Thermography (IRT) is an important non-destructive investigation technique that...

Pan-cancer subtyping in a 2D-map shows substructures that are driven by specific combinations of molecular characteristics

The use of genome-wide data in cancer research, for the identification of groups of patients with similar molecular characteristics, has become a standard approach for applications in therapy-response, prognosis-prediction, and drug-development. To progress in these applications, the trend is to move from single genome-wide measurements in a...

OncoScape: Exploring the cancer aberration landscape by genomic data fusion

Although large-scale efforts for molecular profiling of cancer samples provide multiple data types for many samples, most approaches for finding candidate cancer genes rely on somatic mutations and DNA copy number only. We present a new method, OncoScape, which exploits five complementary data types across 11 cancer types to identify new...

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer

Invasive lobular carcinoma (ILC) is the second most frequently occurring histological breast cancer subtype after invasive ductal carcinoma (IDC), accounting for around 10% of all breast cancers. The molecular processes that drive the development of ILC are still largely unknown. We have performed a comprehensive genomic, transcriptomic and...