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Lassooij, J. (author), Tolou, N. (author), Tortora, G. (author), Caccavaro, S. (author), Menciassi, A. (author), Herder, J.L. (author)This article presents the design of a newly developed 2DoF robotic arm with a novel statically balanced and bi-stable compliant grasper as the end effector for laparoscopic surgery application. The arm is based on internal motors actuating 2 rotational DoFs: pitch and roll. The positive stiffness of the monolithic grasper has been compensated...journal article 2012
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Bier, H.H. (author)Distributed, networked, electronically tagged, interactive devices are increasingly incorporated into the physical envi-ronment blurring progressively the boundary between physical and virtual space. This changing relationship between physical and virtual implies not only a change in the operation and use of buildings but also a change in their...journal article 2012
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Lu, H. (author), Xu, T. (author), Nikookar, H. (author)The development of wireless communication applications in the last few years is unprecedented. Wireless communication has evolved in various ways. The next generation of wireless systems should service more users while supporting mobility and high data rates. These requirements necessitate efficient use of available resources to provide...book chapter 2012
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Van den Berg, B.A. (author), Reinders, M.J.T. (author), Hulsman, M. (author), Wu, L. (author), Pel, H.J. (author), Roubos, J.A. (author), De Ridder, D. (author)Protein sequence features are explored in relation to the production of over-expressed extracellular proteins by fungi. Knowledge on features influencing protein production and secretion could be employed to improve enzyme production levels in industrial bioprocesses via protein engineering. A large set, over 600 homologous and nearly 2,000...journal article 2012
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Zhang, E.F. (author), Savenije, H.H.G. (author), Chen, S.L. (author), Mao, X.H. (author)An analytical model for tidal dynamics has been applied to the Yangtze Estuary for the first time, to describe the tidal propagation in this large and typically branched estuary with three-order branches and four outlets to the sea. This study shows that the analytical model developed for a single-channel estuary can also accurately describe the...journal article 2012
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De Torres, M. (author), Dimroth, J. (author), Arends, I.W.C.E. (author), Keilitz, J. (author), Hollmann, F. (author)Rh(III)-TsDPEN, an immobilized analog of the well-known [Cp*Rh(bpy)(H2O)]2+ was evaluated as a heterogeneous, recyclable regeneration catalyst for reduced oxidoreductase cofactors [NAD(P)H]. Repeated use of this catalyst was established and the catalytic properties were initially investigated. Apparently, Rh(III)-TsDPEN is prone to severe...journal article 2012
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Nikerel, I.E. (author), Berkhout, J. (author), Hu, F. (author), Teusink, B. (author), Reinders, M.J.T. (author), De Ridder, D. (author)Understanding cellular regulation of metabolism is a major challenge in systems biology. Thus far, the main assumption was that enzyme levels are key regulators in metabolic networks. However, regulation analysis recently showed that metabolism is rarely controlled via enzyme levels only, but through non-obvious combinations of hierarchical ...journal article 2012
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Hulsken, B. (author), Vossen, D. (author), Stallinga, S. (author)Array illuminators generating spots with high NA at high efficiency are presented. They are designed via application of high-NA scalar optics methods, and implemented as periodic binary phase structures. These array illuminators are used in a multi-spot scanning microscope for scanning large sample areas with a relatively high resolution.journal article 2012
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Wever, R. (author), Vogtländer, J. (author)The classical sustainability perspective on packaging is to reduce the environmental impact or eco burden of the packaging, using life cycle assessment to evaluate different design alternatives. Simultaneously, the classical marketing perspective on packaging is to generate value through differentiation, for instance, by providing additional...journal article 2012
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Tran, D. (author), Haider, N. (author), Valavan, S.E. (author), Lager, I.E. (author), Szilagyil, A. (author), Yarovyi, O. (author), Ligthart, L.P. (author)Ultra-wideband radio technology (UWB-RT) inherited a potential of extremely high rate of data communications, Claude Shannon discovered this in 1948 and derived the later-called-as Shannon-Hartley‘s channel capacity laws. This famous theoretical law however was not able to substantiate in practice until the development of the sampling...book chapter 2012
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Hollmann, F. (author), Arends, I.W.C.E. (author)Biocatalysis is propagating into practically every area of organic chemistry, amongst them radical polymerizations. A review of the recent developments of this dynamic and quickly evolving area of research is presented together with a critical evaluation of its potential to yield novel polymers and/or environmentally more benign synthetic...journal article 2012
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- Bier, H.H. (author) book chapter 2012
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Ramezani, H. (author), Leus, G. (author)In this paper, we analyze the problem of acoustic ranging between sensor nodes in an underwater environment. The underwater medium is assumed to be composed of multiple isogradient sound speed profile (SSP) layers where in each layer the sound speed is linearly related to the depth. Furthermore, each sensor node is able to measure its depth and...journal article 2012
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Stallinga, S. (author), Rieger, B. (author)We introduce a method for determining the position and orientation of fixed dipole emitters based on a combination of polarimetry and spot shape detection. A key element is an effective Point Spread Function model based on Hermite functions. The model offers a good description of the shape variations with dipole orientation and polarization...journal article 2012
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Lian, X. (author), Nikookar, H. (author), Ligthart, L.P. (author)Cognitive radio (CR) is an intelligent radio system and is able to share the spectrum with licensed users (LU). By adopting adaptive beam forming techniques, CR can reuse the spectrum with LU via directing main beams towards CR users while displaying nulls towards LU. In this article, we present a new distributed beam forming (DB) technique, and...journal article 2012
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A wide spectral range single-photon avalanche diode fabricated in an advanced 180 nm CMOS technologyMandai, S. (author), Fishburn, M.W. (author), Maruyama, Y. (author), Charbon, E. (author)We present a single-photon avalanche diode (SPAD) with a wide spectral range fabricated in an advanced 180 nm CMOS process. The realized SPAD achieves 20 % photon detection probability (PDP) for wavelengths ranging from 440 nm to 820 nm at an excess bias of 4V, with 30 % PDP at wavelengths from 520 nm to 720 nm. Dark count rates (DCR) are at...journal article 2012
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Löschberger, A. (author), Van de Linde, S. (author), Debauvalle, M.C. (author), Rieger, B. (author), Heilemann, M. (author), Krohne, G. (author), Sauer, M. (author)One of the most complex molecular machines of cells is the nuclear pore complex (NPC), which controls all trafficking of molecules in and out of the nucleus. Because of their importance for cellular processes such as gene expression and cytoskeleton organization, the structure of NPCs has been studied extensively during the last few decades,...journal article 2012
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Nijkamp, J.F. (author), Van den Broek, M.A. (author), Datema, E. (author), De Kok, S. (author), Bosman, L. (author), Luttik, M.A.H. (author), Daran-Lapujade, P.A.S. (author), Vongsangnak, W. (author), Nielsen, J. (author), Heijne, W.H.M. (author), Klaassen, P. (author), Paddon, C.J. (author), Platt, D. (author), Kötter, P. (author), Van Ham, R.C. (author), Reinders, M.J.T. (author), Pronk, J.T. (author), De Ridder, D. (author), Daran, J.M. (author)Saccharomyces cerevisiae CEN.PK 113-7D is widely used for metabolic engineering and systems biology research in industry and academia. We sequenced, assembled, annotated and analyzed its genome. Single-nucleotide variations (SNV), insertions/deletions (indels) and differences in genome organization compared to the reference strain S. cerevisiae...journal article 2012
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Wang, Y. (author), Leus, G.J.T. (author)Low-complexity least-squares (LS) estimators based on time-of-arrival (TOA) or time-difference-of-arrival (TDOA) measurements have been developed to locate a target node with the help of anchors (nodes with known positions). They require to select a reference anchor in order to cancel nuisance parameters or relax stringent synchronization...journal article 2012
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Simi, M. (author), Tolou, N. (author), Valdastri, P. (author), Herder, J.L. (author), Menciassi, A. (author), Dario, P. (author)A novel compliant Magnetic Levitation System (MLS) for a wired miniature surgical camera robot was designed, modeled and fabricated. The robot is composed of two main parts, head and tail, linked by a compliant beam. The tail module embeds two magnets for anchoring and manual rough translation. The head module incorporates two motorized donut...journal article 2012