Watergebonden transport en bedrijventerreinen in Zuid- Holland.: Fore- en backcasting van de circulaire economie om de implicaties voor ruimtelijke planning van vandaag te begrijpen

A critical review of arsenic occurrence, fate and transport in natural and modified groundwater systems in The Netherlands

Arsenic is a common trace element in groundwater and its fate and transport are controlled by combination of (i) natural processes, including redox conditions, salinity and pH, (ii) sedimentary and geochemical environment, and (iii) anthropogenic influences such as groundwater extraction, managed aquifer recharge (MAR), Aquifer Thermal Energy...

Benchmarking Outlier Detection Methods for Detecting IEM Patients in Untargeted Metabolomics Data

Untargeted metabolomics (UM) is increasingly being deployed as a strategy for screening patients that are suspected of having an inborn error of metabolism (IEM). In this study, we examined the potential of existing outlier detection methods to detect IEM patient profiles. We benchmarked 30 different outlier detection methods when applied to...

Integration of metabolomics with genomics: Metabolic gene prioritization using metabolomics data and genomic variant (CADD) scores

The integration of metabolomics data with sequencing data is a key step towards improving the diagnostic process for finding the disease-causing genetic variant(s) in patients suspected of having an inborn error of metabolism (IEM). The measured metabolite levels could provide additional phenotypical evidence to elucidate the degree of...

Using out-of-batch reference populations to improve untargeted metabolomics for screening inborn errors of metabolism

Untargeted metabolomics is an emerging technology in the laboratory diagnosis of inborn errors of metabolism (IEM). Analysis of a large number of reference samples is crucial for correcting variations in metabolite concentrations that result from factors, such as diet, age, and gender in order to judge whether metabolite levels are abnormal....

Drinkwaterfunctie Markermeer en verzilting IJsselmeergebied

Het Markermeer is meer ‘climate proof’ dan het IJsselmeer en heeft onder het huidige waterbeheer minder last van verzilting als gevolg van klimaatverandering, zeespiegelstijging en veranderende hydrologie van de Rijn dan het IJsselmeer. Dit blijkt uit een modelstudie waarbij water en chloride dynamisch in de tijd zijn gesimuleerd....