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Biodegradation-affected fatigue behavior of extrusion-based additively manufactured porous iron–manganese scaffolds

Putra, N.E. (author), Moosabeiki, Vahid (author), Leeflang, M.A. (author), Zhou, J. (author), Zadpoor, A.A. (author)

Additively manufactured (AM) biodegradable porous iron-manganese (FeMn) alloys have recently been developed as promising bone-substituting biomaterials. However, their corrosion fatigue behavior has not yet been studied. Here, we present the first study on the corrosion fatigue behavior of an extrusion-based AM porous Fe35Mn alloy under...

journal article 2024

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Rational design and additive manufacturing of grain boundary-inspired, multi-architecture lattice structures

Yang, J. (author), Chen, Xiaohong (author), Sun, Yuanxi (author), Feng, Chen (author), Yang, Zheng (author), Zadpoor, A.A. (author), Mirzaali, Mohammad J. (author), Bai, Long (author)

The advent of additive manufacturing has facilitated the design and fabrication of hybrid lattice structures with multiple morphologies. These structures combine multiple distinct architectures into a single structure with an exceptional performance that far exceeds that of each constituting architecture. However, combining strut-based...

journal article 2023

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Physiomimetic biocompatibility evaluation of directly printed degradable porous iron implants using various cell types

Li, Y. (author), Pavanram, P. (author), Bühring, J. (author), Rütten, S. (author), Schröder, K. U. (author), Zhou, J. (author), Pufe, T. (author), Wang, L. . (author), Zadpoor, A.A. (author), Jahr, H. (author)

Additively manufactured (AM) degradable porous metallic biomaterials offer unique opportunities for satisfying the design requirements of an ideal bone substitute. Among the currently available biodegradable metals, iron has the highest elastic modulus, meaning that it would benefit the most from porous design. Given the successful...

journal article 2023

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Extrusion-based additive manufacturing of Mg-Zn alloy scaffolds

Dong, J. (author), Tümer, N. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zadpoor, A.A. (author), Zhou, J. (author)

Porous biodegradable Mg and its alloys are considered to have a great potential to serve as ideal bone substitutes. The recent progress in additive manufacturing (AM) has prompted its application to fabricate Mg scaffolds with geometrically ordered porous structures. Extrusion-based AM, followed by debinding and sintering, has been recently...

journal article 2022

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Osteoimmunomodulatory potential of 3D printed submicron patterns assessed in a direct co-culture model

Nouri Goushki, M. (author), Eijkel, B.I.M. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)

Modulation of the immune response following the implantation of biomaterials can have beneficial effects on bone regeneration. This involves complex interactions between the inflammatory and osteogenic cells. Therefore, the study of cell-cell interactions using direct co-culture models integrated with biomaterials is of great interest. This...

journal article 2022

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Comparison in clinical performance of surgical guides for mandibular surgery and temporomandibular joint implants fabricated by additive manufacturing techniques

Oldhoff, M. G.E. (author), Mirzaali, Mohammad J. (author), Tümer, N. (author), Zhou, J. (author), Zadpoor, A.A. (author)

Additive manufacturing (AM) offers great design freedom that enables objects with desired unique and complex geometry and topology to be readily and cost-effectively fabricated. The overall benefits of AM are well known, such as increased material and resource efficiency, enhanced design and production flexibility, the ability to create...

journal article 2021

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Fatigue performance of auxetic meta-biomaterials

Kolken, H.M.A. (author), Garcia, A. Fontecha (author), Du Plessis, A. (author), Rans, C.D. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)

Meta-biomaterials offer a promising route towards the development of life-lasting implants. The concept aims to achieve solutions that are ordinarily impossible, by offering a unique combination of mechanical, mass transport, and biological properties through the optimization of their small-scale geometrical and topological designs. In this...

journal article 2021

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The effects of plasma electrolytically oxidized layers containing Sr and Ca on the osteogenic behavior of selective laser melted Ti6Al4V porous implants

van Hengel, I.A.J. (author), Lacin, M. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)

Surface biofunctionalization is frequently applied to enhance the functionality and longevity of orthopedic implants. Here, we investigated the osteogenic effects of additively manufactured porous Ti6Al4V implants whose surfaces were biofunctionalized using plasma electrolytic oxidation (PEO) in Ca/P-based electrolytes with or without...

journal article 2021

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Mechanical performance of auxetic meta-biomaterials

Kolken, H.M.A. (author), Lietaert, K. (author), van der Sloten, T. (author), Pouran, B. (author), Meynen, A. (author), Van Loock, G. (author), Weinans, Harrie (author), Scheys, L. (author), Zadpoor, A.A. (author)

The innovative design of orthopedic implants could play an important role in the development of life-lasting implants, by improving both primary and secondary implant fixations. The concept of meta-biomaterials aims to achieve a unique combination of mechanical, mass transport, and biological properties through optimized topological design of...

journal article 2020

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Functionality-packed additively manufactured porous titanium implants

van Hengel, I.A.J. (author), Gelderman, F. S.A. (author), Athanasiadis, S. (author), Minneboo, M.B. (author), Weinans, Harrie (author), Fluit, A. C. (author), van der Eerden, B.C.J. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)

The holy grail of orthopedic implant design is to ward off both aseptic and septic loosening for long enough that the implant outlives the patient. Questing this holy grail is feasible only if orthopedic biomaterials possess a long list of functionalities that enable them to discharge the onerous task of permanently replacing the native bone...

journal article 2020

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Biofunctionalization of selective laser melted porous titanium using silver and zinc nanoparticles to prevent infections by antibiotic-resistant bacteria

van Hengel, I.A.J. (author), Putra, N.E. (author), Tierolf, M. W.A.M. (author), Minneboo, M.B. (author), Fluit, A. C. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)

Antibiotic-resistant bacteria are frequently involved in implant-associated infections (IAIs), making the treatment of these infections even more challenging. Therefore, multifunctional implant surfaces that simultaneously possess antibacterial activity and induce osseointegration are highly desired in order to prevent IAIs. The incorporation...

journal article 2020

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Continuous and pulsed selective laser melting of Ti6Al4V lattice structures: Effect of post-processing on microstructural anisotropy and fatigue behaviour

Karami, K. (author), Blok, A. (author), Weber, L.R.M. (author), Ahmadi, S.M. (author), Petrov, R.H. (author), Nikolic, Ksenija (author), Borisov, E.V. (author), Leeflang, M.A. (author), Ayas, C. (author), Zadpoor, A.A. (author), Mehdipour, M. (author), Reinton, T.E. (author), Popovich, V. (author)

Additive manufacturing technologies in general and laser powder bed fusion (L-PBF) in particular have been on the rise in different applications, including biomedical implants. The effects of the various L-PBF process parameters on the microstructure and properties of Ti6Al4V lattice structures have been studied before. However, the...

journal article 2020

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Additively manufactured biodegradable porous zinc

Li, Y. (author), Pavanram, P. (author), Zhou, J. (author), Lietaert, K. (author), Taheri, P. (author), Li, W. (author), San, H. (author), Leeflang, M.A. (author), Mol, J.M.C. (author), Jahr, H. (author), Zadpoor, A.A. (author)

Additively manufacturing (AM) opens up the possibility for biodegradable metals to possess uniquely combined characteristics that are desired for bone substitution, including bone-mimicking mechanical properties, topologically ordered porous structure, pore interconnectivity and biodegradability. Zinc is considered to be one of the promising...

journal article 2020

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Solvent-cast 3D printing of magnesium scaffolds

Dong, J. (author), Li, Y. (author), Lin, P. (author), Leeflang, M.A. (author), van Asperen, S. (author), Yu, K. (author), Tümer, N. (author), Norder, B. (author), Zadpoor, A.A. (author), Zhou, J. (author)

Biodegradable porous magnesium (Mg) scaffolds are promising for application in the regeneration of critical-sized bone defects. Although additive manufacturing (AM) carries the promise of offering unique opportunities to fabricate porous Mg scaffolds, current attempts to apply the AM approach to fabricating Mg scaffolds have encountered some...

journal article 2020

document

Corrosion fatigue behavior of additively manufactured biodegradable porous iron

Li, Y. (author), Lietaert, K. (author), Li, W. (author), Zhang, X.Y. (author), Leeflang, M.A. (author), Zhou, J. (author), Zadpoor, A.A. (author)

The corrosion fatigue behavior of additively manufactured topologically ordered porous iron based on diamond unit cells was studied for the first time to understand its response to cyclic loading in a simulated physiological environment. The material exhibited high fatigue resistance with fatigue strengths being 70% and 65% of yield stress in...

journal article 2019

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Additively manufactured biodegradable porous iron

Li, Y. (author), Jahr, H. (author), Lietaert, K. (author), Pavanram, P. (author), Yilmaz, A. (author), Fockaert, L.I. (author), Leeflang, M.A. (author), Pouran, B. (author), Gonzalez Garcia, Y. (author), Weinans, Harrie (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)

Additively manufactured (AM) topologically ordered porous metallic biomaterials with the proper biodegradation profile offer a unique combination of properties ideal for bone regeneration. These include a fully interconnected porous structure, bone-mimicking mechanical properties, and the possibility of fully regenerating bony defects. Most...

journal article 2018

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Fatigue performance of additively manufactured meta-biomaterials: The effects of topology and material type

Ahmadi, S.M. (author), Hedayati, R. (author), Li, Y (author), Lietaert, K. (author), Tümer, N. (author), Fatemi, A. (author), Rans, C.D. (author), Pouran, B. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)

Additive manufacturing (AM) techniques enable fabrication of bone-mimicking meta-biomaterials with unprecedented combinations of topological, mechanical, and mass transport properties. The mechanical performance of AM meta-biomaterials is a direct function of their topological design. It is, however, not clear to what extent the material type...

journal article 2018

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Multiscale modeling of fatigue crack propagation in additively manufactured porous biomaterials

Hedayati, R. (author), Hosseini-Toudeshky, H. (author), Sadighi, M. (author), Mohammadi-Aghdam, M. (author), Zadpoor, A.A. (author)

Advances in additive manufacturing (AM) techniques have enabled fabrication of highly porous titanium implants that combine the excellent biocompatibility of bulk titanium with all the benefits that a regular volume-porous structure has to offer (e.g. lower stiffness values comparable to those of bone). Clinical application of such...

journal article 2018

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Ten guidelines for the design of non-assembly mechanisms: The case of 3D-printed prosthetic hands

Cuellar Lopez, J.S. (author), Smit, G. (author), Zadpoor, A.A. (author), Breedveld, P. (author)

In developing countries, prosthetic workshops are limited, difficult to reach, or even non-existent. Especially, fabrication of active, multi-articulated, and personalized hand prosthetic devices is often seen as a time-consuming and demanding process. An active prosthetic hand made through the fused deposition modelling technology and fully...

journal article 2018

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Additively manufactured biodegradable porous magnesium

Li, Y. (author), Zhou, J. (author), Pavanram, P. (author), Leeflang, M.A. (author), Fockaert, L.I. (author), Pouran, B. (author), Tümer, N. (author), Schröder, K. U. (author), Mol, J.M.C. (author), Weinans, Harrie (author), Jahr, H. (author), Zadpoor, A.A. (author)

An ideal bone substituting material should be bone-mimicking in terms of mechanical properties, present a precisely controlled and fully interconnected porous structure, and degrade in the human body to allow for full regeneration of large bony defects. However, simultaneously satisfying all these three requirements has so far been highly...

journal article 2017