Ultrasound-Mediated Drug Delivery With a Clinical Ultrasound System: In Vitro Evaluation

Chemotherapy efficacy is often reduced by insufficient drug uptake in tumor cells. The combination of ultrasound and microbubbles (USMB) has been shown to improve drug delivery and to enhance the efficacy of several drugs in vitro and in vivo, through effects collectively known as sonopermeation. However, clinical translation of USMB therapy...

Local microbubble concentration by defocused volumetric shadowgraphy with a single camera

The challenge presented in this research is to determine the local volumetric bubble concentration (or void fraction) in the center of a microbubble cloud with limited optical access and without disturbing the flow. By applying defocused volumetric shadowgraphy to an aerated water column we were able to measure the characteristics of single...