Recording 3D neuronal activity on chip with segmented 3D microelectrode arrays

FET-based integrated charge sensing in a MEM organ-on-chip platform

ForceTracker: A versatile tool for contractile force assessment in 3D organ-on-chip platforms

An engineered heart tissue platform with integrated pacing microelectrodes

Miniaturized engineered heart tissues from human induced pluripotent cell-derived co-culture

Miniaturized engineered heart tissues from HiPSC-derived co-culture

A 3D microelectrode array to record neural activity at different tissue depths

In vitro study of high-level neurobiological systems requires three-dimensional (3D) neuronal cultures [1]. Meas-uring responses along all three spatial dimensions is critical to record electric activity inside 3D neuronal models, such as organoids and other 3D brain tissue constructs. However, this lies beyond the capacity of 2D microelec-trode...

FET-based charge sensor for organs-on-chip with in-situ electrode decoration

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Enabling actuation and sensing in organs-on-chip using electroactive polymers

•Actuation has been succesfully performed for 2h30 with no side effects nor<br/>delimination of the human tissue <br/>•0.1 % strain has been achieved during the actutaion mode, close to the<br/>strain experienced in vivo by vSMCs <br/>•0.72 V/mm sensitivity has been shown on the sensing mode <br/>•Batch fabrication and downscaling will be...

Sensor applications for organ-on-chip platforms

Monitoring cell conditions and microenvironment in real time is crucial for Organ-on-Chip (OoC) functionality. In particular, biological cues such as ions, including metals and metabolites, play a critical role in physiology and homeostasis in the human body. • Real-time monitoring of ions without optical systems is an unmet need for OOCs [1]. •...

A miniaturized EHT platform for contractile tissue measurements

We presented the smallest and best characterised EHT devices to date. The devices were fabricated by wafer-scale silicon and polymer processing, characterised by nanoindentation and finite-element simulations, and transferred to 96-well plates for cell seeding and optical tracking of bundle contraction. Cell bundles remained functional for at...